P0CN42

PR
Gene name
TIF32
Protein name
Eukaryotic translation initiation factor 3 subunit A
Names
eIF3a, Eukaryotic translation initiation factor 3 110 kDa subunit homolog, eIF3 p110, Translation initiation factor eIF3, p110 subunit homolog
Species
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

520-952 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CN42

Entry ID Method Resolution Chain Position Source
AF-P0CN42-F1 Predicted AlphaFoldDB

No variants for P0CN42

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CN42

No associated diseases with P0CN42

5 regional properties for P0CN42

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 170 - 178 IPR000629
domain Helicase, C-terminal 235 - 396 IPR001650
domain DEAD/DEAH box helicase domain 48 - 212 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 42 - 239 IPR014001
domain RNA helicase, DEAD-box type, Q motif 23 - 51 IPR014014

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex, eIF3e An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e.
eukaryotic translation initiation factor 3 complex, eIF3m An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m.
multi-eIF complex A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.

2 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
translation reinitiation A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPIYVKPEN ALKRSEELLA LGTPQSQQQA FDNLVEVFQS KRFKQTPINV LEPIVTKFID
70 80 90 100 110 120
LCVVLSRKAH AKSGLLVFKS AAQTTNVGAI ERVLNHFIAK AEARLAAAVE QAKKEVAALP
130 140 150 160 170 180
DVPVVDDDLP LQPASLMLDC FVDSAGDRER IERRLIAPAQ KFCWDSYDIC LDIAKSNDRL
190 200 210 220 230 240
EVIYQSIAHR AFHFCKIHQR KADFRRLCEQ RLRKDLANAA KYSHQQHAIN LSDPETLGRF
250 260 270 280 290 300
LDTRFLQLET AVELELWQEA FRSIEDVHGL IAGRKGTKPS MMANYYEKLT QIFKAEGGKQ
310 320 330 340 350 360
TAVFHAAAWA RYFQHAERAG IVNDKASGCV LLSALAVPLG EVEVKQRLVA LLNLPKTPTR
370 380 390 400 410 420
EALVQDAAAK HLKRVPADIR QIYKILEVDF EPTTASKVLA PLITSLSPEY QPYLPALRDV
430 440 450 460 470 480
VLSRLLQALA QVYDSVTLSH ILDLVKPLDN TPWATDMSSL EKFLVTACRR GDIRASVDHV
490 500 510 520 530 540
AQTITFVSTP PDANGLQTLA VCLYNTIQYL NPSRLAPVSR SDAFAAAIAQ AEEERKAASH
550 560 570 580 590 600
KRQIVIRRRE LLEEAKLRRE KEASTALAER LKIKAEEDAR RAKEEAKQAE IDRVRKQIHE
610 620 630 640 650 660
TKQAEAKQLA ASLAAQGALK VDISSIEDLD SSKLVAMQVE QLAKEKKELS ERLRIVGKRV
670 680 690 700 710 720
DHLERAMRKE ERPLLAQDYE RQKAEDRAAH DRANQIAREQ AIEQQRAARE LKQRLGRMLE
730 740 750 760 770 780
DYEAVKERIE SQMQEELKAA KEEARRKIEE EKAQLREKVI KRKREEKERK LKEAREAEER
790 800 810 820 830 840
KRKEEEEAAQ KAEEEARAAA ALEAEAAAAE QRRAEREAQR QSDLERIRAQ QEREEEALRR
850 860 870 880 890 900
RQAEKAAATS GGSAYRPPAR AGTTPPTASP APSSGGPSWL ARRKAMEAQS AGGAPVASSP
910 920 930 940 950
KPVPSNSAAA SAPASNGPES IAGEAEKPAL TGSVWRRGMG ARRGMPSTRG GA