P0CM88

PR
Gene name
YSH1 (CNH02710)
Protein name
Endoribonuclease YSH1
Names
mRNA 3'-end-processing protein YSH1
Species
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
KEGG Pathway
cne:CNH02710
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

589-682 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CM88

Entry ID Method Resolution Chain Position Source
AF-P0CM88-F1 Predicted AlphaFoldDB

No variants for P0CM88

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CM88

No associated diseases with P0CM88

4 regional properties for P0CM88

Type Name Position InterPro Accession
domain Metallo-beta-lactamase 40 - 252 IPR001279
domain Zn-dependent metallo-hydrolase, RNA specificity domain 407 - 472 IPR011108
domain Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term 501 - 750 IPR021718
domain Beta-Casp domain 269 - 392 IPR022712

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mRNA cleavage and polyadenylation specificity factor complex A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal.

4 GO annotations of molecular function

Name Definition
5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
endoribonuclease activity Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
metal ion binding Binding to a metal ion.
RNA binding Binding to an RNA molecule or a portion thereof.

6 GO annotations of biological process

Name Definition
mRNA 3'-end processing by stem-loop binding and cleavage Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine.
mRNA polyadenylation The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
pre-mRNA cleavage required for polyadenylation The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation.
sno(s)RNA 3'-end processing Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea.
snoRNA splicing The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA.
termination of RNA polymerase II transcription A transcription termination process that completes the production of a primary RNA polymerase II transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIPRRHHFKP APQPTVQVLQ PPDEDAPSLT ITMLGAGQEV GRSCCVIEHR GKKIVCDAGL
70 80 90 100 110 120
HPAQPGIGAL PFIDELDWST VDAMLITHFH VDHAAALPYI MEKTNFKDGN GKVYMTHATK
130 140 150 160 170 180
AIYGLTMMDT VRLNDQNPDT SGRLYDEADV QSSWQSTIAV DYHQDIVIAG GLRFTPYHAG
190 200 210 220 230 240
HVLGASMFLI EIAGLKILYT GDYSREEDRH LVMAEIPPVK PDVMICESTF GVHTLPDRKE
250 260 270 280 290 300
KEEQFTTLVA NIVRRGGRCL MPIPSFGNGQ ELALLLDEYW NDHPELQNIP VYFASSLFQR
310 320 330 340 350 360
GMRVYKTYVH TMNANIRSRF ARRDNPFDFR FVKWLKDPQK LRENKGPCVI MSSPQFMSFG
370 380 390 400 410 420
LSRDLLEEWA PDSKNGVIVT GYSIEGTMAR TLLSEPDHIE SLKGGNVPRR LTVKEISFGA
430 440 450 460 470 480
HVDYAQNSKF IQEIGAQHVV LVHGEASQMG RLRAALRDTY AAKGQEINIH TPKNCEPLTL
490 500 510 520 530 540
TFRQERMVKA IGSLAATRPE HGTSVKGLLV SKDFSYTLLS PADLHDFTGL STSTIIQKQG
550 560 570 580 590 600
VAISVDWAVV RWYLEGMYGE VEEGVEEEGK AAFIIMNGVQ VVQISPTAVE LRWKSSSSND
610 620 630 640 650 660
MIADSALALL LGIDGSPATA KLTASPNKHA CNHSNSHSHT DLYPHTYPGD KSAKDVASNP
670 680 690 700 710 720
EFERLRMFLE AHFGHVEGPN LRPPLPPGAD GDGNDDKDKD GDDWLTMDVK LDNQTARIDL
730 740 750 760 770
ISMRVESESA ELQKRVETVL EMALTTVKSL SQTFLGGGLD VDMVKVEPNE SDS