P0CM79

PR
Gene name
GRC3 (CNBD2080)
Protein name
Polynucleotide 5'-hydroxyl-kinase GRC3
Names
Species
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
KEGG Pathway
cnb:CNBD2080
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-156 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CM79

Entry ID Method Resolution Chain Position Source
AF-P0CM79-F1 Predicted AlphaFoldDB

No variants for P0CM79

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CM79

No associated diseases with P0CM79

1 regional properties for P0CM79

Type Name Position InterPro Accession
domain Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain 331 - 488 IPR032319

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
polynucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA.

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSALAARRAT AAAASPKPEQ PESSIEEVSV SGALTLPSPK RRKTRQTSPK PRSKARYSDD
70 80 90 100 110 120
VPTSRQFFQA TESLAEQRTG RFSPSAPDSD GGTSSSSVGD SDEDMAQEDE FEDRREVDGE
130 140 150 160 170 180
RDQRKVSVAA NMSSSGPFKS LDLMPVDITS QFNPKDNVNF CRITEGQLAS AEMNDGHPGP
190 200 210 220 230 240
GVIVSLARNE SLTIAGLFLL TPLQNTLSIY STALSPSMSS FPVYAPTSHP LPVISPASTQ
250 260 270 280 290 300
APGKESDKTL LLIRENRCGI DGLRNGAVPG FSNIWLEDNG PWGLRGVHPV VGSFPVPVYP
310 320 330 340 350 360
YCTPPSWSHA ISSLSSSDVN LQTPFVGLVK GPKRSGKSTF ARALLNNLLR RFRKVAWLEC
370 380 390 400 410 420
DLGQGEFGSG AVVGLWILDK PALGPPFTHP LLPSRSHYLG TYTPLTCPDE YLVAIRHLIE
430 440 450 460 470 480
HYKYELQYTS EYSALHTTVH DKISTHVPLV INTQGWMKGL GEELLNVIES MAQPTRVFSF
490 500 510 520 530 540
ESQSEEVYSG QGWTSTPPWQ ATQLPYDPAY PTTEPVETEV TQTYSLETAP VSALQARYTP
550 560 570 580 590 600
ADLRVLSAIT YFHASLHPTQ SVPVTWDISS PLVCTIPWEV ELGIGKALEK VYLIGEGSEG
610 620 630 640 650 660
VLEEDLPIAL NGAIVALAEM LGSYEDEPTV YEQGRSPPPT DLVNILGLAV IRSLSSGNSV
670 680 690 700 710 720
NPGLKLQLLT PLPPSYLSRA RILIKSGALE LPLPGMIDWR RGGINEEGML GKGWEEIPFL
730 740
DVGGLDVIGG ERRRFRKNIM RKGM