P0CL05

PR
Gene name
nei
Protein name
Endonuclease 8
Names
DNA glycosylase/AP lyase Nei, DNA-(apurinic or apyrimidinic site) lyase Nei, Endonuclease VIII
Species
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG Pathway
stm:STM0728
EC number
4.2.99.18: Other carbon-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CL05

Entry ID Method Resolution Chain Position Source
AF-P0CL05-F1 Predicted AlphaFoldDB

No variants for P0CL05

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CL05

No associated diseases with P0CL05

6 regional properties for P0CL05

Type Name Position InterPro Accession
domain Zinc finger, DNA glycosylase/AP lyase-type 229 - 263 IPR000214
domain Zinc finger, FPG/IleRS-type 235 - 263 IPR010663
domain Formamidopyrimidine-DNA glycosylase, catalytic domain 1 - 111 IPR012319
domain DNA glycosylase/AP lyase, H2TH DNA-binding 126 - 221 IPR015886
binding_site DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site 238 - 262 IPR015887
domain Nei, N-terminal 2 - 116 IPR044091

Functions

Description
EC Number 4.2.99.18 Other carbon-oxygen lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
class I DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate.
damaged DNA binding Binding to damaged DNA.
DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPEGPEIRRA ADNLEAAIKG KPLTDVWFAF AQLKPYESQL TGQLVTRIET RGKALLTHFS
70 80 90 100 110 120
NGLTLYSHNQ LYGVWRVIDT GEIPQTTRIL RVRLQTADKT ILLYSASDIE MLTAEQLTTH
130 140 150 160 170 180
PFLQRVGPDV LDARLTPEEV KARLLSPRFR NRQFSGLLLD QSFLAGLGNY LRVEILWQVG
190 200 210 220 230 240
LTGQHKAKDL NEAQLNALSH ALLDIPRLSY TTRGQADENK HHGALFRFKL FHRDGEACER
250 260
CGGIIEKTTL SSRPFYWCPH CQK