P0CG99

PR
Gene name
nrdE1 (MSMEG_1019, MSMEI_0990)
Protein name
Ribonucleoside-diphosphate reductase subunit alpha 1
Names
Ribonucleotide reductase R1 subunit 1
Species
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
KEGG Pathway
msm:MSMEG_1019
EC number
1.17.4.1: With a disulfide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

428-501 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CG99

Entry ID Method Resolution Chain Position Source
AF-P0CG99-F1 Predicted AlphaFoldDB

No variants for P0CG99

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CG99

No associated diseases with P0CG99

4 regional properties for P0CG99

Type Name Position InterPro Accession
domain Ribonucleotide reductase large subunit, C-terminal 184 - 702 IPR000788
domain Ribonucleotide reductase, class I, alpha subunit, C-terminal 111 - 704 IPR013346
domain Ribonucleotide reductase large subunit, N-terminal 107 - 179 IPR013509
domain Ribonucleotide reductase N-terminal 24 - 105 IPR013554

Functions

Description
EC Number 1.17.4.1 With a disulfide as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPPTVTAAEP VTTTGHVLPG EADYHALNAM LNLYDADGKI QFEKDREAAK QYFLQHVNQN
70 80 90 100 110 120
TVFFHSQDEK LDYLIENEYY EREVLDQYSR DFIKSLLDRA YAKKFRFPTF LGAFKYYTSY
130 140 150 160 170 180
TLKTFDGKRY LERFEDRVVM VALTLAAGDT ELAEKLVDEI IDGRFQPATP TFLNSGKKQR
190 200 210 220 230 240
GEPVSCFLLR IEDNMESIGR SINSALQLSK RGGGVALLLS NIREHGAPIK NIENQSSGVI
250 260 270 280 290 300
PIMKLLEDSF SYANQLGARQ GAGAVYLHAH HPDIYRFLDT KRENADEKIR IKTLSLGVVI
310 320 330 340 350 360
PDITFELAKK NEDMYLFSPY DVERVYGVPF ADVSVTEKYY EMVDDARIRK TKINAREFFQ
370 380 390 400 410 420
TLAELQFESG YPYIMFEDTV NRSNPIAGKI THSNLCSEIL QVSTPSEFND DLSYAKVGKD
430 440 450 460 470 480
ISCNLGSLNI AKAMDSPDFA QTIEVAIRAL TAVSDQTHIT SVPSIEQGNN DSHAIGLGQM
490 500 510 520 530 540
NLHGYLARER IYYGSEEGID FTNIYFYTVL FHALRASNKI AIERGTHFKG FEKSKYASGE
550 560 570 580 590 600
FFDKYTDQVW EPKTDKVRRL FADADIHIPT QDDWKQLKES VQKHGIYNQN LQAVPPTGSI
610 620 630 640 650 660
SYINHSTSSI HPVASKIEIR KEGKIGRVYY PAPYMTNDNL DYYQDAYEIG YEKIIDTYAA
670 680 690 700 710 720
ATQHVDQGLS LTLFFKDTAT TRDVNKAQIY AWRKGIKTLY YIRLRQMALE GTEVEGCVSC
ML