P0CG22

PR
Gene name
DHRS4L1
Protein name
Putative dehydrogenase/reductase SDR family member 4-like 1
Names
Short chain dehydrogenase/reductase family 25C member 4, Protein SDR25C4
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0CG22

Entry ID Method Resolution Chain Position Source
AF-P0CG22-F1 Predicted AlphaFoldDB

No variants for P0CG22

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0CG22

No associated diseases with P0CG22

1 regional properties for P0CG22

Type Name Position InterPro Accession
conserved_site Short-chain dehydrogenase/reductase, conserved site 172 - 200 IPR020904

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

1 GO annotations of molecular function

Name Definition
carbonyl reductase (NADPH) activity Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.

1 GO annotations of biological process

Name Definition
retinal metabolic process The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BTZ2 DHRS4 Dehydrogenase/reductase SDR family member 4 Homo sapiens (Human) PR
10 20 30 40 50 60
MHKARLRGHC ARAGKSVRLA SSGMTRRDPL TNKVALVTAS TDWIGFAVAQ RLAQDGAHVV
70 80 90 100 110 120
VSRRKQQNVD QAVATLQGEG LSMTGTVCHV GKMKDWERLV ATAMKLHGVI DILSLSITNS
130 140 150 160 170 180
KRGLFWFTLL QTAEEAWDRN LDINGKALAL MIKAVVPEME KRGGGSVGFL ASVAAFRPLP
190 200 210 220 230 240
GFSPYNVSKT ALLGLNKTLA IELAPRNIRV NCLAPGLIKT SFSRMLWMDK EKEESMKETL
250 260 270 280
RIRRLGEPED SLGIVSFLCS EDASYLTGET VMVGGGTPSR L