P0C664

PR
Gene name
zwl-1 (CBG03981)
Protein name
Protein zwilch homolog
Names
Species
Caenorhabditis briggsae
KEGG Pathway
cbr:CBG_03981
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

50-130 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0C664

Entry ID Method Resolution Chain Position Source
AF-P0C664-F1 Predicted AlphaFoldDB

No variants for P0C664

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0C664

No associated diseases with P0C664

5 regional properties for P0C664

Type Name Position InterPro Accession
domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 536 - 860 IPR002073
domain GAF domain 164 - 324 IPR003018-1
domain GAF domain 346 - 513 IPR003018-2
domain HD/PDEase domain 610 - 787 IPR003607
conserved_site 3'5'-cyclic nucleotide phosphodiesterase, conserved site 653 - 664 IPR023174

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cell cortex
  • Chromosome, centromere, kinetochore
  • Cytoplasm, cytoskeleton, spindle
  • Localizes to the kinetochore during nuclear envelope breakdown and remains there until the metaphase-anaphase transition
  • Localizes to kinetochores, spindle-associated rod-shaped structures and near the cell cortex in a knl-1-dependent manner in anaphase
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
RZZ complex A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints.
spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

7 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
mitotic spindle assembly checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
positive regulation of mitotic spindle pole body separation Any process that increases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane.
positive regulation of protein localization to kinetochore Any process that activates or increases the frequency, rate or extent of protein localization to kinetochore.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.
protein localization to kinetochore involved in kinetochore assembly Any protein localization to kinetochore that is involved in kinetochore assembly.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSIKLEDLHS FNEAVLFKGE EDEAPAPVLL LDKYRVRLVP ITELPLVSNY SNTSQLGLNS
70 80 90 100 110 120
EEVLVIDSPI ESAEKQKTSS LLNRRENKKT IKSEKEDESM DMETAEGDKE NTVSETGGGP
130 140 150 160 170 180
LVTSFLTLDK LEKDGVNDVE IVGLDCEIQF FDANPIPFED GISLQRFLRL ESSKNFSAAV
190 200 210 220 230 240
DKLPIWISTI GHHFPSVCWL AAGRTNKNVQ VSGATRILGY FNENSQKLVK QLNEACGAAQ
250 260 270 280 290 300
VNRYRAVYDV IRKIATPTRE APGEVIIDMR WNTKSSLVLL EQPDNAADCT IKIDLGWGDN
310 320 330 340 350 360
RFFIDETIFE QLFFVLNLAD VLANPEKEVV FRSESDKFDD LVQEMKQLVE ACSHEDNVFA
370 380 390 400 410 420
SNEKSEQVTD KVWNIVRKCS DVKQATMLFK NFLQALTYGK IKSHVQEGNK SHLASLIRAS
430 440 450 460 470 480
KTCDFRMPIL ERLSTIEMMM EIGVESLRGR IINKFSDTLQ FPSDELTFIL KTCENDLSTL
490 500 510 520 530 540
EGTLHSSVVS LLPITMAMAT IHQIFGFLNV KDLVVLPDLA RRVLTKYTTG MVEKAKRGET
550 560 570 580 590 600
ETDYVFETTL PLLRMNKEAF MHKRPRIWTC ENTNTVGANV QTRAMTTLEL EPSLEHVCRL
610 620 630
VNASRPVRPI DEDNRKPTEE ERNADYTVSH TIFSYLPKL