P0C5E7

PR
Gene name
age-1 (CBG02868)
Protein name
Phosphatidylinositol 3-kinase age-1
Names
PI3-kinase age-1, PI3K age-1, PtdIns-3-kinase age-1, Aging alteration protein 1
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
2.7.1.137: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0C5E7

Entry ID Method Resolution Chain Position Source
AF-P0C5E7-F1 Predicted AlphaFoldDB

No variants for P0C5E7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0C5E7

No associated diseases with P0C5E7

7 regional properties for P0C5E7

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain 246 - 366 IPR000341
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 858 - 1159 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 607 - 803 IPR001263
domain C2 phosphatidylinositol 3-kinase-type domain 422 - 588 IPR002420
domain Phosphatidylinositol 3-kinase, adaptor-binding domain 79 - 182 IPR003113
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 894 - 908 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 1016 - 1036 IPR018936-2

Functions

Description
EC Number 2.7.1.137 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
phosphatidylinositol 3-kinase complex A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
1-phosphatidylinositol-4-phosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.

8 GO annotations of biological process

Name Definition
aging A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
dauer larval development The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.
phosphatidylinositol 3-kinase signaling A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSMGRSSSTT FRNRTASHGS RSLGSAETAR IPRKLSSQLS HTHANILHPQ LQTMMEQWQM
70 80 90 100 110 120
RERPSLETEN GKGSLLLSSE GVADMIVLSS FGEVISVVFP WFLANVRTSF DIKLSEFKHQ
130 140 150 160 170 180
LFEQIGPMKW GKHSTQPQDY AFRQLNNFGE IEVIFNDDQQ LSCLELHGTF PMLFLFEPDG
190 200 210 220 230 240
FNRDKELMCD ISHCLGYSLD KLEESIDEEL RQFRASLWTQ TKKTCFERGV DGVDHYAFPE
250 260 270 280 290 300
EQYFCVGEKC PTDLESKVKA AKLDYQLFWT KRKSEANEVW EKMYKITIDF DPEFNPQSLM
310 320 330 340 350 360
RMFVKELQCM NLFDPEDPPD EEWILQLAGR TSFVTRPEIS LVSYDGIRSE LESYRCPGFV
370 380 390 400 410 420
VRRKSLVLKD YVRPKPLYEP HYVRVHERKM ALDVLSVSIG TEVKHSGNSD KVWTDFRPTA
430 440 450 460 470 480
SLEQITLWDL DSNLMIRPVN VTGLPFTASH DIYLGMEFKV YVGTLTLATI KIPRVPTTKL
490 500 510 520 530 540
VWKREFFTFD LYMKDMPPSA ILSVRVYSMK TTKMKEEIEL GWVNISLSDW RDELRQGQIK
550 560 570 580 590 600
LNLWGPEPSA NRSRIGHNGA KIGTSLSVTV EISSHGRRVK MPNEAQYKYL VDHRISWSDT
610 620 630 640 650 660
VEIVGDDYEA CIGDPGYKKL QDLVKKHESG VILDDSEQRH VWSWRNYIQK QEPDLLVVLS
670 680 690 700 710 720
ELRIVWTDRE NFSELYVMLE TWKAPSVAAA LTLLGKRCTD RVIRKFAVNK LNDQLSQFNV
730 740 750 760 770 780
HLFLLPLIQA LKYEPRAYSE VGMMLLTRAL SSYRIGHRLF WLLRSEICRL KDCATNNEEY
790 800 810 820 830 840
RRISLLMEAY LRGNEEHIKG IIRQVDMVDE LTRISSLVKG LSKEAAREKL RDQLRTISHK
850 860 870 880 890 900
MESIDSPLDP VYKFGEMVIE KAIVLGSAKQ PLRLVWKNKN PKSDLHLPFC EVIFKNGDDL
910 920 930 940 950 960
RQDMLVLQVL EVMDTIWKAA NIDCCLSPYG VLPMGEMIGI IEVVPNCKTI FEIQHKAGLV
970 980 990 1000 1010 1020
NTAARSVDSN FMNKWIRKQC GFVDEKKKYK KGGGPTVDSA QATKKYFESV DRFLYSCVGY
1030 1040 1050 1060 1070 1080
SVATYIMGIK DRHSDNLMLT EDGKYFHIDF GHILGHGKTK LGIQRDRQPF ILTEQFLTII
1090 1100 1110 1120 1130 1140
RSGKPVDGNS HEIQKFKTLC LEAYEVMWNN LKYKFQKTLC CKGETKEKAR KFFAGVYEEA
1150
FNGSWSTKTN WLFHAMKHY