AiPD: Autoinhibited Protein Database

P0C1Z6

Gene name	TFPT (INO80F)
Protein name	TCF3 fusion partner
Names	INO80 complex subunit F, Protein FB1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:29844
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-253 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-253 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P0C1Z6

Entry ID	Method	Resolution	Chain	Position	Source
AF-P0C1Z6-F1	Predicted				AlphaFoldDB

236 variants for P0C1Z6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA407788171 rs1193141793	5	Q>H		No	ClinGen TOPMed
CA407788174 rs1180763350	5	Q>R		No	TOPMed gnomAD ClinGen
rs1458028512 CA407788157	7	E>Q		No	ClinGen gnomAD
CA407788140 rs1239984117	8	G>E		No	gnomAD ClinGen
rs777367685 CA309317822	9	T>S		No	ExAC gnomAD ClinGen
rs1192822450 CA407788039	10	M>I		No	gnomAD ClinGen
rs1474507713 CA407788037	11	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
CA407788027 rs1241584778	12	A>P		No	gnomAD ClinGen
CA309317808 rs754380542	13	V>A		No	ExAC gnomAD ClinGen
CA407787987 rs1313116720	15	F>S		No	gnomAD ClinGen
rs750853355 CA309317796	17	E>D		No	ExAC gnomAD ClinGen
CA309317793 rs376999253	18	F>L		No	ESP ExAC gnomAD ClinGen
rs1336894892 CA407787919	19	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
CA407787879 rs1381300743	21	P>L		No	TOPMed ClinGen
CA309317770 rs587617418	24	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA309317769 rs762884888	25	E>D		No	ExAC gnomAD ClinGen
rs1157014752 CA407787752	27	A>T		No	TOPMed ClinGen
CA309317754 rs781018410	28	L>M		No	ExAC TOPMed gnomAD ClinGen
rs1454715686 CA407787589	34	G>D		No	gnomAD ClinGen
rs747676603 CA309317657	41	L>P		No	ExAC gnomAD ClinGen
CA407787331 rs1368887473	44	E>G		No	TOPMed ClinGen
TCGA novel	44	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	45	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1255721224 CA407787240	49	S>T		No	ClinGen gnomAD
rs960809894 CA309317627	51	G>S		No	TOPMed ClinGen
CA407787145 rs1309970433	52	L>R		No	TOPMed ClinGen
CA309317612 rs373003232	54	G>S		No	ESP ExAC TOPMed gnomAD ClinGen
CA407787073 rs1437718116	55	S>*		No	gnomAD ClinGen
CA309317604 rs928059728	56	G>E		No	Ensembl ClinGen
CA407787041 rs1256897300	57	L>I		No	gnomAD ClinGen
CA407787036 rs1185242712	57	L>P		No	gnomAD ClinGen
CA407787026 rs1310254845	58	R>G		No	TOPMed gnomAD ClinGen
CA309317585 rs757494817	58	R>Q		No	ClinGen ExAC gnomAD
CA407786959 rs1227376487	60	R>P		No	gnomAD ClinGen
CA407786929 rs201672137	61	D>E		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs139955385 CA309317568	63	E>D		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA407786885 rs1394523441	63	E>K		No	TOPMed ClinGen
TCGA novel	64	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1399519424 CA407786846	64	E>D		No	gnomAD ClinGen
rs763233664 CA309317552	64	E>Q		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	65	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA309317526 rs770740513	68	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs1467307059 CA407786758	68	R>W		No	gnomAD ClinGen
CA309317519 rs759494963	69	G>S		No	ExAC gnomAD ClinGen
rs146000517 CA309317509	69	G>V		No	ESP TOPMed ClinGen
CA407786706 COSM1326190 rs1162947527	70	R>Q	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	TOPMed ClinGen cosmic curated NCI-TCGA
rs1209744902 CA407786707	70	R>W		No	TOPMed gnomAD ClinGen
CA309317493 rs776513954	71	R>P		No	ExAC gnomAD ClinGen
rs776513954 CA309317497	71	R>Q		No	ExAC gnomAD ClinGen
rs746834418 CA309317470	74	Q>R		No	ExAC ClinGen
CA407786580 rs1568574351	75	R>P		No	Ensembl ClinGen
CA407786526 rs1302736933	77	L>S		No	ClinGen gnomAD
rs587648855 CA309317469	78	N>H		No	1000Genomes ExAC gnomAD ClinGen
rs1568574320 CA407786495	78	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	Ensembl ClinGen NCI-TCGA
CA309317468 rs771658243	79	R>C		No	ClinGen ExAC gnomAD
CA309317466 rs747776427	79	R>L		No	ExAC TOPMed ClinGen
TCGA novel	82	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1399388261 TCGA novel CA407786333	84	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA TOPMed ClinGen
rs1389639177 CA407786281	87	R>Q		No	TOPMed ClinGen
CA407786290 rs1212332415	87	R>W		No	gnomAD ClinGen
CA309317449 rs754496341	88	R>G		No	ExAC gnomAD ClinGen
rs781740615 CA309317431	90	R>L		No	ExAC gnomAD ClinGen
rs781740615 CA407786217	90	R>Q		No	ExAC gnomAD ClinGen
rs142515991 CA309317443	90	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
rs587751545 CA309317425	91	E>K		No	1000Genomes ExAC gnomAD ClinGen
rs752870810 CA309317419	92	I>M		No	ExAC gnomAD ClinGen
rs758601188 CA309317423	92	I>T		No	ExAC TOPMed ClinGen
CA407786149 rs1568574190	93	E>*		No	Ensembl ClinGen
CA407786130 rs1291130439	94	Q>*		No	TOPMed ClinGen
CA309313720 rs372825631	95	V>M		No	ESP ExAC gnomAD ClinGen
CA407784498 COSM713810 rs1051140983 CA309313710	96	N>K	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	TOPMed gnomAD ClinGen cosmic curated NCI-TCGA
rs761642321 CA309313700	97	E>G		No	ExAC gnomAD ClinGen
CA407784495 rs767220147	97	E>K		No	ExAC TOPMed gnomAD ClinGen
rs767220147 CA407784493	97	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs774272913 CA309313697	98	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs1600297864 CA407784465	99	V>G		No	Ensembl ClinGen
rs1263660453 CA407784446	101	N>S		No	TOPMed gnomAD ClinGen
CA309313671 rs774912384	102	R>G		No	ExAC gnomAD ClinGen
CA407784435 rs1244070857	102	R>K		No	TOPMed ClinGen
CA309313664 rs369765889	102	R>S		No	ESP ExAC TOPMed gnomAD ClinGen
rs1233867142 CA407784421	103	L>H		No	gnomAD ClinGen
CA407784407 rs1293444922	104	H>R		No	gnomAD ClinGen
rs940733213 CA309313649	105	Q>H		No	Ensembl ClinGen
CA309313641 rs772441947	106	V>L		No	ExAC gnomAD ClinGen
CA309313635 rs772441947	106	V>M		No	ExAC gnomAD ClinGen
TCGA novel	108	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200361982 CA407784331	111	R>G		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA309313608 rs375419473	111	R>Q		No	ESP TOPMed ClinGen
rs200361982 CA309313611	111	R>W		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA407784320 rs1273545952	112	R>K		No	gnomAD ClinGen
CA407784313 rs1600297644	112	R>S		No	Ensembl ClinGen
CA407784289 rs1220428572	114	Q>H		No	TOPMed gnomAD ClinGen
CA309313602 rs138024173	115	Q>H		No	ESP ExAC TOPMed gnomAD ClinGen
rs150437143 CA309313591	116	E>Q		No	ESP ExAC TOPMed gnomAD ClinGen
rs750339337 CA407784251	117	R>G		No	ExAC TOPMed gnomAD ClinGen
rs761840525 CA309313539	117	R>L		No	ExAC gnomAD ClinGen
rs761840525 CA309313550	117	R>Q		No	ExAC gnomAD ClinGen
CA309313570 rs750339337	117	R>W		No	ExAC TOPMed gnomAD ClinGen
rs751442251 CA309313510	118	R>T		No	ExAC gnomAD ClinGen
TCGA novel	120	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA309311793 rs753500915	121	M>K		No	ExAC gnomAD ClinGen
rs753500915 CA309311791	121	M>T		No	ExAC gnomAD ClinGen
CA407782540 rs751160649 CA407782543	123	V>L		No	ExAC gnomAD ClinGen
rs751160649 CA407782545	123	V>M		No	ExAC gnomAD ClinGen
TCGA novel	126	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs970875427 CA309311772	127	Y>C		No	gnomAD ClinGen
CA309311779 rs755756976	127	Y>H		No	ExAC TOPMed gnomAD ClinGen
CA407782445 rs1360427920	128	G>R		No	Ensembl ClinGen
rs1374391939 CA407782427	129	D>N		No	gnomAD ClinGen
CA309311750 rs141461777	131	Y>C		No	ESP ExAC gnomAD ClinGen
CA309311747 rs753104719	132	R>Q		No	ExAC TOPMed gnomAD ClinGen
CA309311748 rs148303725	132	R>W		No	ESP ExAC TOPMed gnomAD ClinGen
rs1443447059 CA407782311	136	F>L		No	gnomAD ClinGen
rs1281320796 CA407782279	138	I>F		No	gnomAD ClinGen
CA309311713 rs777126350	138	I>M		No	ExAC gnomAD ClinGen
CA309311715 rs759925165	138	I>T		No	ExAC TOPMed gnomAD ClinGen
CA407782245 rs1277243567	140	L>P		No	gnomAD ClinGen
rs1277243567 CA407782242	140	L>R		No	gnomAD ClinGen
CA407782125 rs1387396149	142	D>H		No	gnomAD ClinGen
CA309311571 rs761006755	142	D>V		No	ClinGen ExAC
CA309311566 rs773236546	143	E>*		No	ExAC ClinGen
rs767644731 CA309311561	143	E>D		No	ClinGen ExAC gnomAD
rs1272376789 CA407782075	144	G>D		No	ClinGen TOPMed
rs761856411 CA309311557	144	G>S		No	ExAC TOPMed gnomAD ClinGen
CA407782068 rs1237063641	145	S>R		No	TOPMed gnomAD ClinGen
rs1055973936 CA309311549	146	Q>E		No	Ensembl ClinGen
rs1448407063 CA407782037	146	Q>R		No	TOPMed ClinGen
CA407782026 rs1481313637	147	G>A		No	gnomAD ClinGen
CA407782028 rs1481313637	147	G>D		No	ClinGen gnomAD
CA407782031 rs1286254299	147	G>S		No	TOPMed gnomAD ClinGen
CA309311544 rs375487904	148	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA407781998 rs1322123023	150	A>P		No	TOPMed gnomAD ClinGen
rs1322123023 CA407782000	150	A>T		No	TOPMed gnomAD ClinGen
rs1182793122 CA407781988	151	P>S		No	TOPMed ClinGen
CA407781979 rs1311809936	152	T>A		No	TOPMed gnomAD ClinGen
rs769539637 CA309311496	152	T>I		No	ExAC gnomAD ClinGen
CA407781977 rs1311809936	152	T>S		No	TOPMed gnomAD ClinGen
CA309311485 rs761143770	153	P>S		No	Ensembl ClinGen
rs780651901 CA309311478	154	G>D		No	ExAC TOPMed gnomAD ClinGen
CA407781932 rs1365575190	155	N>D		No	gnomAD ClinGen
CA407781907 rs1232104130	155	N>S		No	gnomAD ClinGen
rs201891249 CA407781888	156	A>E		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs201891249 CA309311472	156	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA407781881 rs200459700	157	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA407781879 rs200459700	157	E>Q		No	ESP ExAC TOPMed gnomAD ClinGen
rs1381524737 CA407781853	158	N>I		No	gnomAD ClinGen
CA407781858 rs1419446436	158	N>Y		No	gnomAD ClinGen
CA407781824 rs1420421950	160	P>H		No	gnomAD ClinGen
rs1288625916 CA407781776	163	K>E		No	TOPMed gnomAD ClinGen
rs766850986 CA309311445	163	K>R		No	ExAC gnomAD ClinGen
CA407781744 rs1220264646	164	E>D		No	TOPMed ClinGen
rs756487327 CA309311430	165	T>A		No	ExAC gnomAD ClinGen
CA309311401 rs767698135	166	L>P		No	ExAC TOPMed gnomAD ClinGen
CA309311392 rs762062470	167	S>P		No	ClinGen ExAC TOPMed gnomAD
rs774342975 CA309311386	168	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA407781672 rs762910213	169	P>A		No	ExAC TOPMed gnomAD ClinGen
rs762910213 CA309311362	169	P>S		No	ExAC TOPMed gnomAD ClinGen
rs769591725 CA309311340	170	R>K		No	ExAC TOPMed gnomAD ClinGen
rs1361561872 CA407781595	173	P>L		No	gnomAD ClinGen
rs1291143443 CA407781588	174	A>T		No	gnomAD ClinGen
rs1375463024 CA407781567	175	P>L		No	gnomAD ClinGen
rs142642138 CA309311315	175	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ESP ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA407781556 rs1480466945	176	P>Q		No	TOPMed gnomAD ClinGen
rs1480466945 CA407781553	176	P>R		No	TOPMed gnomAD ClinGen
CA309311313 rs770531913	176	P>T		No	ExAC gnomAD ClinGen
CA407781504 rs1191059293	179	G>S		No	TOPMed gnomAD ClinGen
rs749824870 CA309311295	182	A>D		No	ExAC TOPMed gnomAD ClinGen
rs749824870 CA407781422	182	A>G		No	ExAC TOPMed gnomAD ClinGen
rs749824870 CA309311294	182	A>V		No	ExAC TOPMed gnomAD ClinGen
CA407781401 rs1259651286	183	P>H		No	gnomAD ClinGen
rs1434803502 CA407781406	183	P>S		No	gnomAD ClinGen
rs370305737 CA309311286	184	G>D		No	ESP ExAC TOPMed gnomAD ClinGen
CA309311290 rs200020589	184	G>S		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1568564339 CA407781296	187	P>S		No	Ensembl ClinGen
CA309311270 rs762965314	189	G>V		No	ExAC gnomAD ClinGen
CA309311259 rs371509951	190	R>Q		No	ESP ExAC TOPMed gnomAD ClinGen
CA309311260 COSM1229061 rs765229548	190	R>W	large_intestine [Cosmic]	No	ExAC TOPMed gnomAD ClinGen cosmic curated
rs770714341 CA407781174	192	R>K		No	ExAC TOPMed gnomAD ClinGen
rs770714341 CA407781170	192	R>M		No	ExAC TOPMed gnomAD ClinGen
rs368833895 CA407781162	193	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs147735140 CA309311247	193	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA309311256 rs368833895	193	R>W		No	ESP ExAC TOPMed gnomAD ClinGen
CA309311211 rs747723515	194	R>*		No	ExAC TOPMed gnomAD ClinGen
CA309311205 rs587666544	194	R>Q		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA407781148 rs1195110017	195	V>M		No	ClinGen gnomAD
CA309311177 rs200497052	197	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs372980800 CA309311181	197	R>W		No	ExAC TOPMed gnomAD ClinGen
CA309311172 rs781439874	199	G>R		No	ExAC gnomAD ClinGen
CA309311166 rs140973668	200	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs751744667 CA309311160	200	R>H		No	ExAC TOPMed gnomAD ClinGen
rs751744667 CA407781051	200	R>L		No	ExAC TOPMed gnomAD ClinGen
TCGA novel	200	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA309311155 rs778029287	201	R>*		No	ExAC TOPMed gnomAD ClinGen
rs587639297 CA407781018	201	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs587639297 CA407781024	201	R>Q		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs1300696950 CA407780922	204	N>K		No	TOPMed ClinGen
CA407780908 rs545448952	205	A>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	1000Genomes ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA309311132 rs545448952	205	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	1000Genomes ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA309311119 rs753773339	206	L>P		No	ExAC TOPMed gnomAD ClinGen
rs760574312 CA407780857	207	T>I		No	ExAC gnomAD ClinGen
rs760574312 CA309311104	207	T>N		No	ExAC gnomAD ClinGen
rs766098166 CA309311116	207	T>P		No	ExAC gnomAD ClinGen
CA407780776 rs1169269396	211	A>T		No	gnomAD ClinGen
CA407780737 rs1295398705	212	P>A		No	TOPMed gnomAD ClinGen
CA309311093 rs201832670	212	P>L		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs774020839 CA309311087	213	V>E		No	ClinGen ExAC gnomAD
CA407779128 rs1397198376	215	I>M		No	TOPMed gnomAD ClinGen
rs897235839 CA309310537	215	I>T		No	gnomAD ClinGen
CA309310532 rs755146722	217	V>A		No	ExAC gnomAD ClinGen
CA309310533 rs761247321	217	V>I		No	ExAC TOPMed gnomAD ClinGen
rs1358318073 CA407779091	218	E>K		No	gnomAD ClinGen
CA407779081 rs1167210836	219	E>K		No	gnomAD ClinGen
CA309310507 rs149913762	220	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs139073279 CA309310501	223	F>S		No	ESP ExAC TOPMed gnomAD ClinGen
rs756140239 CA309310496	224	E>*		No	ExAC gnomAD ClinGen
CA309310486 rs750346120	225	A>G		No	ExAC gnomAD ClinGen
rs767423431 CA309310473	228	A>V		No	ExAC gnomAD ClinGen
CA407778779 rs587748485	236	R>P		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs587748485 CA309310436	236	R>Q		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs763875464 CA309310442	236	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA
CA407778772 rs1283536632	237	G>S		No	gnomAD ClinGen
CA407778749 rs1224909501	238	P>R		No	gnomAD ClinGen
CA309310411 rs764606714	244	Y>*		No	ExAC TOPMed gnomAD ClinGen
rs369757230 CA309310402	245	P>L		No	ESP ExAC TOPMed gnomAD ClinGen
rs369757230 CA309310406	245	P>Q		No	ESP ExAC TOPMed gnomAD ClinGen
CA407778634 rs369757230	245	P>R		No	ESP ExAC TOPMed gnomAD ClinGen
CA407778639 rs1431156512	245	P>S		No	gnomAD ClinGen
CA407778621 rs1468951447	246	T>I		No	TOPMed ClinGen
CA407778628 rs1469414268	246	T>P		No	gnomAD ClinGen
rs576494595 CA309310390	248	A>T		No	Ensembl ClinGen
rs34939501 CA309310366	251	A>G		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs151148202 CA309310372	251	A>S		No	ESP ExAC TOPMed gnomAD ClinGen
CA309310349 rs780212681	253	D>A		No	ExAC gnomAD ClinGen
CA309310344 rs769926922	253	D>E		No	ExAC gnomAD ClinGen
rs749420696 CA309310354	253	D>H		No	ExAC TOPMed gnomAD ClinGen
rs749420696 CA407778513	253	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD ClinGen NCI-TCGA

No associated diseases with P0C1Z6

1 regional properties for P0C1Z6

Type	Name	Position	InterPro Accession
domain	Tubulin epsilon and delta complex protein 1 domain	86 - 256	IPR027996

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
actin filament	A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Ino80 complex	A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein-containing complex binding	Binding to a macromolecular complex.

15 GO annotations of biological process

Name	Definition
apoptotic signaling pathway	The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
chromatin remodeling	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
DNA recombination	Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
DNA repair	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
male gonad development	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of DNA repair	Any process that activates or increases the frequency, rate or extent of DNA repair.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of telomere maintenance in response to DNA damage	Any process that activates or increases the frequency, rate or extent of telomere maintenance in response to DNA damage.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of chromosome organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.
regulation of DNA replication	Any process that modulates the frequency, rate or extent of DNA replication.
regulation of DNA strand elongation	Any process that modulates the rate, frequency or extent of DNA strand elongation. DNA strand elongation is the DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand.
regulation of embryonic development	Any process that modulates the frequency, rate or extent of embryonic development.
telomere maintenance	Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q17QH7	TFPT	TCF3 fusion partner homolog	Bos taurus (Bovine)	PR
Q3U1J1	Tfpt	TCF3 fusion partner homolog	Mus musculus (Mouse)	PR
Q9JMG6	Tfpt	TCF3 fusion partner homolog	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MELEQREGTM	AAVGFEEFSA	PPGSELALPP	LFGGHILESE	LETEVEFVSG	GLGGSGLRER
70	80	90	100	110	120
DEEEEAARGR	RRRQRELNRR	KYQALGRRCR	EIEQVNERVL	NRLHQVQRIT	RRLQQERRFL
130	140	150	160	170	180
MRVLDSYGDD	YRASQFTIVL	EDEGSQGTDA	PTPGNAENEP	PEKETLSPPR	RTPAPPEPGS
190	200	210	220	230	240
PAPGEGPSGR	KRRRVPRDGR	RAGNALTPEL	APVQIKVEED	FGFEADEALD	SSWVSRGPDK
250
LLPYPTLASP	ASD