P0C1G6

PR
Gene name
SWAP70
Protein name
Switch-associated protein 70
Names
SWAP-70
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

323-435 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0C1G6

Entry ID Method Resolution Chain Position Source
AF-P0C1G6-F1 Predicted AlphaFoldDB

No variants for P0C1G6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0C1G6

No associated diseases with P0C1G6

1 regional properties for P0C1G6

Type Name Position InterPro Accession
domain Pleckstrin homology domain 210 - 308 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Nucleus
  • Cell projection, lamellipodium
  • In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus
  • In activated, class-switching B-cells it is associated with membrane IgG but not IgM
  • Localized to loose actin filament arrays located behind actively extending lamellipodia (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UH65 SWAP70 Switch-associated protein 70 Homo sapiens (Human) PR
10 20 30 40 50 60
MGSLKDELLK GIWHAFTALD LDHSGKVSKS QLKVLSHNLC TVLKVPHDPV ALEEHFRDDD
70 80 90 100 110 120
EGPVSNQGYM PYLNKFILEK VQDNFDKIEF NRMCWTLCVK KNLTKNPLFI TEEDAFKIWV
130 140 150 160 170 180
IFNFLSEDKY PLIIVPEEIE YLLKKLTEAM GVSWQQEQFE NYKINFDDSK DGLSAWELIE
190 200 210 220 230 240
LVGNGQFSKG MDRQTVSMAI NEVFNELILD VLKQGYMIKK GHRRKNWTER WFVLKPHIIS
250 260 270 280 290 300
YYVSEDLKDK KGDILLDENC CVESLPDKDG KKCLFLIKCF DKTFEISASD KKKKQEWIQA
310 320 330 340 350 360
IHSTIHLLKL GSPPPHKEAR QRRKELRKKL LAEQEELERQ MKELQIANEN KQQELEAVRK
370 380 390 400 410 420
KLEEAASRAA EEEKKRLQTQ VELQARFSTE LEREKLIRQQ MEEQVAQKSS ELEQYLQRVR
430 440 450 460 470 480
ELEDMYLKLQ EALEDERQAR QDEETVRKLQ ARLLEEESSK RAELEKWHLE QQQAIQTTEA
490 500 510 520 530 540
EKQELENQRV IKEQALQEAL EQLQQLELER KQALEQYEGV KKKLEMAAKM TKSWKDKVAH
550 560 570 580
HEGLIRLIEP GSKNAHLITN WGPAAFTQAE LEERQKSWKE KKTTE