P0C198

PR
Gene name
CHK1 (UMAG_11087)
Protein name
Serine/threonine-protein kinase CHK1
Names
Checkpoint kinase 1
Species
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
KEGG Pathway
uma:UMAG_11087
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

321-608 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

210-235 (Activation loop from InterPro)

Target domain

18-328 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P0C198

Entry ID Method Resolution Chain Position Source
AF-P0C198-F1 Predicted AlphaFoldDB

No variants for P0C198

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0C198

No associated diseases with P0C198

4 regional properties for P0C198

Type Name Position InterPro Accession
domain Protein kinase domain 18 - 328 IPR000719
active_site Serine/threonine-protein kinase, active site 189 - 201 IPR008271
binding_site Protein kinase, ATP binding site 24 - 49 IPR017441
domain Checkpoint kinase 1, catalytic domain 16 - 328 IPR034670

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint.
protein phosphorylation The process of introducing a phosphate group on to a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTIPKSSTGQ SYPPVLDYRI VQLIGGGGFS KVFRAVNPSS ESHSVAAIKV ISYAPNRSNK
70 80 90 100 110 120
YPIDRRALQK EVQVHSILKH PNVLEFLGAV ERGVDKNGNA GKEKGILMGE AVATTKESIR
130 140 150 160 170 180
ARDKERQQML SSPSHDQNYV PGLYMVLELG AGGDLFDKIA PDYGVEEDLA HFYFQQLLAG
190 200 210 220 230 240
LEYIHSQGVT HRDIKPENML LDAEGNLKIA DFGLCSVYKY KGKERELTGA CGSLPYIAPE
250 260 270 280 290 300
MNGKPYRGEP VDVWSSGVVL FAMLVGSTPW DEPTSRSPEY SAYRTGKLFE YDPWPRIPQD
310 320 330 340 350 360
ALSLLKKMMH PTPEKRITFE GIRRHRWFKR ANDLMTQKGK CNDPVNLAEK LLQGLAVSGD
370 380 390 400 410 420
IIVEVNGAAA AAARRLDLHS DGQRAQVPEN VSLTQPDAIL TSSFDLAARA VARGWADDTG
430 440 450 460 470 480
PGGGLPLPSS TAMPAFASDD MSRRLAMSQH ISSRRAEFST TASGSGYDMA LPGASQFTQA
490 500 510 520 530 540
LNHFTQFEAL THVAGTGSSH LRFSPHLTRF FSSASAATIL ALIIDVLDRL AVLNAHQAIG
550 560 570 580 590 600
DQEELELEEA YNFMADGEPE TTVPSDDSSR PTGGSKRLLI GSRGARIRLK TMDRRKCVLR
610 620 630 640 650 660
GEVYVENLAA PDSTSDSASA PDRNAAKCLV VMKKGKGDPL EWRRLFREVC RRPEIMQTII
ST