P0C062

PR
Gene name
grsA (grs1)
Protein name
Gramicidin S synthase 1
Names
Gramicidin S synthase I
Species
Brevibacillus brevis (Bacillus brevis)
KEGG Pathway
ag:BAA00406
EC number
5.1.1.11: Acting on amino acids and derivatives
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P0C062

Entry ID Method Resolution Chain Position Source
5ISW X-ray 175 A A 538-1098 PDB
5ISX X-ray 233 A A/B 538-1098 PDB
AF-P0C062-F1 Predicted AlphaFoldDB

No variants for P0C062

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0C062

No associated diseases with P0C062

8 regional properties for P0C062

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 45 - 436 IPR000873
domain Condensation domain 621 - 1081 IPR001242
ptm Phosphopantetheine attachment site 568 - 583 IPR006162
domain Phosphopantetheine binding ACP domain 538 - 612 IPR009081
domain Non-ribosomal peptide synthase 928 - 1089 IPR010060
domain Amino acid adenylation domain 66 - 460 IPR010071
conserved_site AMP-binding, conserved site 187 - 198 IPR020845
domain AMP-binding enzyme, C-terminal domain 444 - 517 IPR025110

Functions

Description
EC Number 5.1.1.11 Acting on amino acids and derivatives
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ligase activity Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
phenylalanine racemase (ATP-hydrolyzing) activity Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+).

2 GO annotations of biological process

Name Definition
antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLNSSKSILI HAQNKNGTHE EEQYLFAVNN TKAEYPRDKT IHQLFEEQVS KRPNNVAIVC
70 80 90 100 110 120
ENEQLTYHEL NVKANQLARI FIEKGIGKDT LVGIMMEKSI DLFIGILAVL KAGGAYVPID
130 140 150 160 170 180
IEYPKERIQY ILDDSQARML LTQKHLVHLI HNIQFNGQVE IFEEDTIKIR EGTNLHVPSK
190 200 210 220 230 240
STDLAYVIYT SGTTGNPKGT MLEHKGISNL KVFFENSLNV TEKDRIGQFA SISFDASVWE
250 260 270 280 290 300
MFMALLTGAS LYIILKDTIN DFVKFEQYIN QKEITVITLP PTYVVHLDPE RILSIQTLIT
310 320 330 340 350 360
AGSATSPSLV NKWKEKVTYI NAYGPTETTI CATTWVATKE TTGHSVPIGA PIQNTQIYIV
370 380 390 400 410 420
DENLQLKSVG EAGELCIGGE GLARGYWKRP ELTSQKFVDN PFVPGEKLYK TGDQARWLPD
430 440 450 460 470 480
GNIEYLGRID NQVKIRGHRV ELEEVESILL KHMYISETAV SVHKDHQEQP YLCAIFVSEK
490 500 510 520 530 540
HIPLEQLRQF SSEELPTYMI PSYFIQLDKM PLTSNGKIDR KQLPEPDLTF GMRVDYEAPR
550 560 570 580 590 600
NEIEETLVTI WQDVLGIEKI GIKDNFYALG GDSIKAIQVA ARLHSYQLKL ETKDLLKYPT
610 620 630 640 650 660
IDQLVHYIKD SKRRSEQGIV EGEIGLTPIQ HWFFEQQFTN MHHWNQSYML YRPNGFDKEI
670 680 690 700 710 720
LLRVFNKIVE HHDALRMIYK HHNGKIVQIN RGLEGTLFDF YTFDLTANDN EQQVICEESA
730 740 750 760 770 780
RLQNSINLEV GPLVKIALFH TQNGDHLFMA IHHLVVDGIS WRILFEDLAT AYEQAMHQQT
790 800 810 820 830 840
IALPEKTDSF KDWSIELEKY ANSELFLEEA EYWHHLNYYT DNVQIKKDYV TMNNKQKNIR
850 860 870 880 890 900
YVGMELTIEE TEKLLKNVNK AYRTEINDIL LTALGFALKE WADIDKIVIN LEGHGREEIL
910 920 930 940 950 960
EQMNIARTVG WFTSQYPVVL DMQKSDDLSY QIKLMKENLR RIPNKGIGYE IFKYLTTEYL
970 980 990 1000 1010 1020
RPVLPFTLKP EINFNYLGQF DTDVKTELFT RSPYSMGNSL GPDGKNNLSP EGESYFVLNI
1030 1040 1050 1060 1070 1080
NGFIEEGKLH ITFSYNEQQY KEDTIQQLSR SYKQHLLAII EHCVQKEDTE LTPSDFSFKE
1090
LELEEMDDIF DLLADSLT