AiPD: Autoinhibited Protein Database

P0C025

Gene name	NUDT17
Protein name	Nucleoside diphosphate-linked moiety X motif 17
Names	Nudix motif 17
Species	Homo sapiens (Human)
KEGG Pathway	hsa:200035
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-96 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for P0C025

Entry ID	Method	Resolution	Chain	Position	Source
5LF8	X-ray	256 A	A	1-328	PDB
AF-P0C025-F1	Predicted				AlphaFoldDB

351 variants for P0C025

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1007593303 CA29810978	2	A>T		No	ClinGen TOPMed gnomAD
CA29810981 rs765156404	3	E>*		No	ClinGen ExAC TOPMed gnomAD
CA1058675 rs765156404	3	E>K		No	ClinGen ExAC TOPMed gnomAD
CA29810984 rs1040502375	4	V>M		No	ClinGen gnomAD
rs901803727 CA29810989	5	R>P		No	ClinGen Ensembl
rs1462489130 CA342115647	6	V>A		No	ClinGen TOPMed
rs993523792 CA29810991	6	V>L		No	ClinGen Ensembl
rs782606515 CA1058674	8	L>P		No	ClinGen ExAC TOPMed gnomAD
CA342115683 rs1263461117	8	L>V		No	ClinGen TOPMed gnomAD
rs1553732009 CA342115717	10	L>V		No	ClinGen gnomAD
rs1553732013 CA342115747	11	S>F		No	ClinGen gnomAD
rs1338952594 CA342115763	12	R>Q		No	ClinGen TOPMed gnomAD
rs1553732017 CA342115758	12	R>W		No	ClinGen gnomAD
rs782540724 CA342115788	13	R>L		No	ClinGen gnomAD
rs782337799 CA1058673	13	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1327062333 CA342115793	14	P>S		No	ClinGen TOPMed
rs1553732043 CA342115853	17	V>M		No	ClinGen gnomAD
rs782505484 CA1058670	18	S>I		No	ClinGen ExAC gnomAD
CA29811102 rs375107467	18	S>R		No	ClinGen ESP ExAC gnomAD
CA342115909 rs1553732048	19	F>S		No	ClinGen gnomAD
rs1553732049 CA342115931	20	A>P		No	ClinGen gnomAD
CA1058668 rs782613814	21	R>P		No	ClinGen ExAC gnomAD
CA342115945 rs1553732052	21	R>W		No	ClinGen gnomAD
rs368322884 CA1058665	22	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA342116012 rs1553732065	24	C>W		No	ClinGen gnomAD
CA342116023 rs1475472951	25	G>D		No	ClinGen TOPMed
rs1553732066 CA342116014	25	G>S		No	ClinGen gnomAD
rs1553732073 CA342116055	27	L>V		No	ClinGen gnomAD
CA342116077 rs1553732077	28	G>R		No	ClinGen gnomAD
rs1553732080 CA342116103	29	A>V		No	ClinGen gnomAD
CA1058664 rs782562286	30	G>E		No	ClinGen ExAC gnomAD
rs1553732083 CA342116113 COSM397059	30	G>R	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA29811126 rs782562286	30	G>V		No	ClinGen ExAC gnomAD
rs1553732085 CA342116135	31	P>S		No	ClinGen gnomAD
rs781887599 CA1058663	32	G>A		No	ClinGen ExAC gnomAD
rs1570762478 CA342116157	32	G>R		No	ClinGen Ensembl
rs782793720 CA1058662	34	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1553732094 CA342116225	35	T>A		No	ClinGen gnomAD
CA1058659 rs202239856	37	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1058660 rs781975471	37	P>S		No	ClinGen ExAC gnomAD
CA342116293 rs1197709010	38	I>T		No	ClinGen TOPMed gnomAD
CA342116283 rs1271189379	38	I>V		No	ClinGen TOPMed gnomAD
rs587694841 CA1058656	40	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1553732109 CA342116364	41	S>N		No	ClinGen gnomAD
rs1553732109 CA342116375	41	S>T		No	ClinGen gnomAD
rs927742244 CA29811191	43	K>Q		No	ClinGen Ensembl
rs1244505283 CA342116429	44	R>*		No	ClinGen TOPMed gnomAD
CA29811198 rs782252512	44	R>L		No	ClinGen ExAC gnomAD
rs782252512 CA1058655	44	R>Q		No	ClinGen ExAC gnomAD
rs1553732120 CA342116452	45	G>A		No	ClinGen gnomAD
CA342116438 rs1553732119	45	G>R		No	ClinGen gnomAD
CA342116456 rs868946439	46	R>G		No	ClinGen TOPMed gnomAD
rs1441959361 CA342116473	46	R>Q		No	ClinGen TOPMed gnomAD
rs868946439 CA342116459	46	R>W		No	ClinGen TOPMed gnomAD
CA342116480 rs1553732131	47	L>F		No	ClinGen gnomAD
rs781975388 CA1058654	47	L>H		No	ClinGen ExAC gnomAD
CA342116531 rs1553732134	49	L>F		No	ClinGen gnomAD
CA342116556 rs1553732141	50	S>L		No	ClinGen gnomAD
rs782205752 CA1058652	50	S>P		No	ClinGen ExAC gnomAD
CA342116567 rs1410123802	51	S>N		No	ClinGen TOPMed
CA342116616 rs1161124340	53	P>S		No	ClinGen TOPMed
CA342116656 rs868980777	55	P>Q		No	ClinGen Ensembl
CA342116650 rs1553732155	55	P>S		No	ClinGen gnomAD
CA342116658 rs1553732158	56	G>S		No	ClinGen gnomAD
rs1553732160 CA342116675	57	A>P		No	ClinGen gnomAD
CA29811266 rs782669675	59	A>P		No	ClinGen ExAC gnomAD
CA1058648 rs782669675	59	A>S		No	ClinGen ExAC gnomAD
rs1553732168 CA342116708	60	R>K		No	ClinGen gnomAD
CA1058647 rs782514095	61	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1553732173 CA342116725	62	P>L		No	ClinGen gnomAD
rs1553732173 CA342116723	62	P>Q		No	ClinGen gnomAD
CA342116744 rs1553732181	64	Q>H		No	ClinGen gnomAD
CA29811307 rs781858734	64	Q>P		No	ClinGen ExAC gnomAD
CA1058644 rs781858734	64	Q>R		No	ClinGen ExAC gnomAD
CA1058618 rs375355925	65	R>*		No	ClinGen ESP ExAC gnomAD
rs781787418 CA1058617	66	P>H		No	ClinGen ExAC TOPMed gnomAD
rs1035159901 CA29811647	67	P>R		No	ClinGen gnomAD
rs782818895 CA1058616	69	C>G		No	ClinGen ExAC gnomAD
CA342116790 rs1481532114	69	C>Y		No	ClinGen TOPMed gnomAD
rs868980908 CA342116799	70	P>R		No	ClinGen gnomAD
CA342116797 rs1553732296	70	P>S		No	ClinGen gnomAD
rs782149724 CA1058615	71	F>S		No	ClinGen ExAC gnomAD
rs868979228 CA342116811	72	A>V		No	ClinGen Ensembl
CA342116812 rs1553732301	73	A>T		No	ClinGen gnomAD
CA342116830 rs141678266	75	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1570763552 CA342116832	76	E>Q		No	ClinGen Ensembl
rs782328085 CA1058611	77	R>G		No	ClinGen ExAC TOPMed gnomAD
CA342116841 rs1553732315	77	R>Q		No	ClinGen gnomAD
rs782328085 CA1058610	77	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1553732322 CA342116844	78	P>H		No	ClinGen gnomAD
rs988324956 CA29811709	78	P>S		No	ClinGen TOPMed gnomAD
rs988324956 CA342116842	78	P>T		No	ClinGen TOPMed gnomAD
TCGA novel	79	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1058608 rs782681937	80	V>I		No	ClinGen ExAC gnomAD
rs1559158557 CA342116862	81	P>L		No	ClinGen Ensembl
rs1212316944 CA342116869	83	A>T		No	ClinGen TOPMed
rs782413956 CA1058607	84	E>Q		No	ClinGen ExAC gnomAD
rs1553732341 CA342116894	87	T>A		No	ClinGen gnomAD
rs979616687 CA29811725	89	R>G		No	ClinGen TOPMed
rs1553732342 CA342116908	89	R>Q		No	ClinGen gnomAD
CA342116912 rs1270702568	90	G>R		No	ClinGen TOPMed
CA342116921 rs1451755468	91	V>A		No	ClinGen TOPMed gnomAD
CA342116917 rs1553732347	91	V>M		No	ClinGen gnomAD
CA342116932 rs1553732351	93	L>V		No	ClinGen gnomAD
rs782608945 CA1058604	94	G>A		No	ClinGen ExAC TOPMed gnomAD
rs782608945 CA342116939	94	G>V		No	ClinGen ExAC TOPMed gnomAD
rs782468402 CA1058603	97	V>A		No	ClinGen ExAC gnomAD
CA342116955 rs1471100335	97	V>I		No	ClinGen TOPMed gnomAD
rs371090124 CA1058602	98	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1553732371 CA342116969	100	Q>R		No	ClinGen gnomAD
CA342116978 rs1169966044	101	S>F		No	ClinGen TOPMed gnomAD
CA342116979 rs374333965	102	S>G		No	ClinGen gnomAD
rs782576215 CA1058601	102	S>R		No	ClinGen ExAC gnomAD
rs1553732380 CA342116985	103	D>N		No	ClinGen gnomAD
CA342116995 rs1553732383	104	K>R		No	ClinGen gnomAD
CA342117004 rs1553732388	105	T>I		No	ClinGen gnomAD
CA342117001 rs1421673252	105	T>S		No	ClinGen TOPMed
rs1553732390 CA342117011	106	V>A		No	ClinGen gnomAD
CA1058598 rs782768416	107	L>M		No	ClinGen ExAC gnomAD
CA342117020 rs587654875	108	L>P		No	ClinGen 1000Genomes gnomAD
CA29811792 rs587654875	108	L>Q		No	ClinGen 1000Genomes gnomAD
CA342117026 rs368699805	109	T>I		No	ClinGen ESP TOPMed gnomAD
rs368699805 CA342117025	109	T>N		No	ClinGen ESP TOPMed gnomAD
rs1553732395 CA342117029	110	R>*		No	ClinGen gnomAD
CA29811798 rs976256792	110	R>P		No	ClinGen Ensembl
rs1205947687 CA342117033	111	R>W		No	ClinGen TOPMed
CA1058597 rs41314015	112	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs781843662 CA1058596	113	R>C		No	ClinGen ExAC gnomAD
rs782734985 CA342117044	113	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs782734985 CA1058595	113	R>P		No	ClinGen ExAC gnomAD
CA342117049 rs1553732404	114	T>I		No	ClinGen gnomAD
rs1201919849 CA342117055	115	L>P		No	ClinGen TOPMed
rs148412329 CA1058593	116	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1058592 rs782439418	117	V>G		No	ClinGen ExAC gnomAD
rs782152369 CA1058591	118	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1553732418 CA342117075	119	P>L		No	ClinGen gnomAD
rs1553732418 CA342117076	119	P>R		No	ClinGen gnomAD
rs1316956169 CA342117084	120	N>K		No	ClinGen TOPMed
CA342117081 rs1553732424	120	N>T		No	ClinGen gnomAD
CA29811844 rs887736779	121	L>F		No	ClinGen gnomAD
rs942018544 CA29811845	122	W>L		No	ClinGen gnomAD
CA342117099 rs1553732435	123	V>I		No	ClinGen gnomAD
rs1372263023 CA342117110	124	P>L		No	ClinGen TOPMed
CA342117107 rs1453129700	124	P>S		No	ClinGen TOPMed
CA342117116 rs1553732444	125	P>L		No	ClinGen gnomAD
CA342117111 rs1553732442	125	P>T		No	ClinGen gnomAD
rs782001827 CA1058542	128	H>Q		No	ClinGen ExAC gnomAD
CA342117927 rs1553732516	129	V>M		No	ClinGen gnomAD
rs1553732517 CA342117958	130	E>D		No	ClinGen gnomAD
CA1058541 rs782762413	133	E>K		No	ClinGen ExAC TOPMed gnomAD
rs782099588 CA1058540	134	E>V		No	ClinGen ExAC TOPMed gnomAD
rs587710326 CA1058522	137	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA342118234 rs1553732559	138	G>E		No	ClinGen gnomAD
CA1058520 rs782806528	139	G>W		No	ClinGen ExAC TOPMed gnomAD
COSM895230 rs782007808 CA1058519	141	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA1058518 rs782007808	141	R>G		No	ClinGen ExAC gnomAD
CA1058517 rs145860956	141	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA342118352 rs1169904234	144	W>*		No	ClinGen TOPMed
rs781930517 CA1058515	146	E>A		No	ClinGen ExAC gnomAD
rs1553732568 CA342118382	146	E>K		No	ClinGen gnomAD
rs1559159101 CA526253121	148	G>*		No	ClinGen Ensembl
CA1058514 rs199712477	148	G>A		No	ClinGen ExAC TOPMed gnomAD
CA29812422 rs199712477	148	G>E		No	ClinGen ExAC TOPMed gnomAD
CA526253122 rs1559159105	148	G>E		No	ClinGen Ensembl
CA1058513 rs781944277	149	L>*		No	ClinGen ExAC
TCGA novel	150	H>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1570765085 CA342118460	150	H>P		No	ClinGen Ensembl
rs1020634902 CA29812432	151	L>V		No	ClinGen TOPMed gnomAD
CA342118543 rs1188592416	156	F>L		No	ClinGen TOPMed
rs1000597933 CA29812464	157	S>F		No	ClinGen Ensembl
CA342118568 rs1570765143	158	W>R		No	ClinGen Ensembl
CA342118579 rs1437433819	159	V>I		No	ClinGen TOPMed gnomAD
TCGA novel	160	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782381474 CA1058509	160	P>L		No	ClinGen ExAC gnomAD
CA342118624 rs1553732584	163	L>S		No	ClinGen gnomAD
rs1207416362 CA342118633	164	W>*		No	ClinGen TOPMed
rs782615139 CA1058507	164	W>R		No	ClinGen ExAC TOPMed gnomAD
rs1232663950 CA342118783	166	S>P		No	ClinGen TOPMed gnomAD
rs781782982 CA1058475	167	A>D		No	ClinGen ExAC gnomAD
CA888518898 rs1329344381	168	Y>*		No	ClinGen TOPMed
CA342118801 rs1304063667	168	Y>C		No	ClinGen TOPMed gnomAD
rs782805518 CA1058474	168	Y>D		No	ClinGen ExAC gnomAD
CA29813140 rs782805518	168	Y>N		No	ClinGen ExAC gnomAD
CA342118823 rs1553732773	170	P>L		No	ClinGen gnomAD
rs1553732774 CA342118826	171	R>W		No	ClinGen gnomAD
CA342118854 rs1318918522	173	S>I		No	ClinGen TOPMed
rs1318918522 CA342118855	173	S>N		No	ClinGen TOPMed
CA342118859 rs1388945151	173	S>R		No	ClinGen TOPMed
CA342118868 rs1553732781	174	W>S		No	ClinGen gnomAD
CA342118885 rs1175185990	175	G>D		No	ClinGen TOPMed gnomAD
CA342118878 rs1553732788	175	G>S		No	ClinGen gnomAD
rs782572045 CA342118956	180	H>Q		No	ClinGen TOPMed gnomAD
rs782795924 CA1058468	180	H>R		No	ClinGen ExAC
CA342118935 rs1553732790	180	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA342118966 rs368251563	181	H>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA1058467 rs368251563	181	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1553732793 CA342119798	182	I>V		No	ClinGen gnomAD
rs1570766377 CA342119810	183	V>I		No	ClinGen Ensembl
rs1199581405 CA342119833	185	Y>H		No	ClinGen TOPMed
CA1058464 rs375787974	188	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1058463 rs375787974	188	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs781994978 CA1058459	190	S>A		No	ClinGen ExAC gnomAD
rs782335086 CA1058458	191	Q>R		No	ClinGen ExAC gnomAD
rs371186827 CA342119908	192	E>*		No	ClinGen ESP TOPMed
rs782217720 CA1058457	192	E>G		No	ClinGen ExAC gnomAD
rs782601251 CA1058456	194	Q>K		No	ClinGen ExAC gnomAD
CA342119930 rs1553732808	194	Q>R		No	ClinGen gnomAD
rs1553732810 CA342119945	195	Q>R		No	ClinGen gnomAD
CA342119957 rs1553732811	196	Q>L		No	ClinGen gnomAD
rs1553732815 CA342119984	198	Q>H		No	ClinGen gnomAD
rs201402956 CA1058430	200	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM423704 rs201402956 CA1058429	200	R>Q	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs781805420 CA1058431	200	R>W		No	ClinGen ExAC TOPMed gnomAD
CA1058427 rs144514921	202	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA1058426 rs370569724	202	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1553732934 CA342120149	203	P>R		No	ClinGen gnomAD
rs782043047 CA1058425	207	E>A		No	ClinGen ExAC TOPMed gnomAD
rs781893766 CA1058424	208	V>M		No	ClinGen ExAC gnomAD
rs907639472 CA29813428	209	S>C		No	ClinGen TOPMed gnomAD
rs782117564 CA1058422	210	A>T		No	ClinGen ExAC gnomAD
rs782005984 CA1058421	210	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1058419 rs376191661	211	L>P		No	ClinGen ESP ExAC gnomAD
CA342120314 rs1455403236	212	M>K		No	ClinGen TOPMed
rs1386772125 CA342120342	213	W>*		No	ClinGen TOPMed
CA1058418 rs201103422	215	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA29813463 rs898862774	216	P>L		No	ClinGen Ensembl
CA1058417 rs782322102	216	P>T		No	ClinGen ExAC gnomAD
rs782670840 CA29813491	217	D>E		No	ClinGen ExAC gnomAD
CA342120420 rs1401376530	217	D>G		No	ClinGen TOPMed
CA1058415 rs782273869	217	D>H		No	ClinGen ExAC gnomAD
CA1058412 rs782376396	218	V>I		No	ClinGen ExAC gnomAD
rs1553732959 CA342120470	220	A>T		No	ClinGen gnomAD
CA1058411 rs782255046	220	A>V		No	ClinGen ExAC gnomAD
rs1171404251 CA342120484	221	A>T		No	ClinGen TOPMed
CA1058410 rs782596675	221	A>V		No	ClinGen ExAC gnomAD
CA342120514 rs61729646	222	V>G		No	ClinGen Ensembl
rs1570767285 CA342120523	223	A>P		No	ClinGen Ensembl
CA29813553 rs781784766	224	A>G		No	ClinGen ExAC gnomAD
CA1058408 rs781784766	224	A>V		No	ClinGen ExAC gnomAD
CA1058406 rs201851608	225	A>T		No	ClinGen ExAC TOPMed gnomAD
rs76141448 CA29813580	226	E>G		No	ClinGen Ensembl
rs895936218 CA29813578	226	E>Q		No	ClinGen Ensembl
rs782776323 CA1058403	228	G>A		No	ClinGen ExAC gnomAD
CA1058404 rs782776323	228	G>E		No	ClinGen ExAC gnomAD
rs1553732978 CA342120654	229	T>A		No	ClinGen gnomAD
rs1553732980 CA342120669	230	E>Q		No	ClinGen gnomAD
CA342120716 rs1188352424	231	T>I		No	ClinGen TOPMed gnomAD
rs1311174553 CA342120754	233	G>E		No	ClinGen TOPMed gnomAD
CA1058400 rs139528449	233	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	233	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1058397 rs587692764	237	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1553732993 CA342120832	237	Q>K		No	ClinGen gnomAD
CA342120842 rs1220923519	237	Q>R		No	ClinGen TOPMed
rs1345661004 CA342120871	238	D>E		No	ClinGen TOPMed gnomAD
CA342120851 rs1553732995	238	D>N		No	ClinGen gnomAD
CA342120879 rs1296734055	239	L>V		No	ClinGen TOPMed gnomAD
CA342120890 rs1553732999	240	P>T		No	ClinGen gnomAD
CA1058396 rs782818981	241	P>L		No	ClinGen ExAC gnomAD
rs587629676 CA1058395	242	S>A		No	ClinGen 1000Genomes ExAC
CA1058394 rs781999110	243	V>I		No	ClinGen ExAC gnomAD
TCGA novel	244	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA342120961 rs1553733009	244	L>P		No	ClinGen gnomAD
CA342121197 rs1570768051	247	E>A		No	ClinGen Ensembl
rs1553733087 CA342121220	248	L>P		No	ClinGen gnomAD
CA1058375 rs112245472	250	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA29813930 rs903395603	252	G>R		No	ClinGen gnomAD
rs1553733102 CA342121339	253	R>S		No	ClinGen gnomAD
CA1058371 rs372461314	253	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs782700883 CA342121347	254	A>P		No	ClinGen ExAC TOPMed gnomAD
rs782700883 CA1058370	254	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1058369 rs782062001	255	R>*		No	ClinGen ExAC gnomAD
rs782410344 CA1058368	255	R>P		No	ClinGen ExAC TOPMed gnomAD
CA342121373 rs782410344	255	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1553733108 CA342121390	256	P>T		No	ClinGen gnomAD
rs781960772 CA1058365	258	V>L		No	ClinGen ExAC gnomAD
rs1553733113 CA342121448	259	L>Q		No	ClinGen gnomAD
CA342121455 rs1353025554	260	H>Y		No	ClinGen TOPMed gnomAD
CA342121494 rs1261357317	261	M>I		No	ClinGen TOPMed gnomAD
rs1553733118 CA342121485	261	M>T		No	ClinGen gnomAD
rs782358638 CA1058364	262	S>A		No	ClinGen ExAC gnomAD
rs191785243 CA1058363	262	S>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1333617 rs781948166 CA1058361	263	T>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs781948166 CA1058360	263	T>N		No	ClinGen ExAC gnomAD
CA1058358 rs587611781	266	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs139025436 CA1058356	266	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139025436 CA1058355	266	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs587611781 CA1058357	266	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA1058354 rs781797302	267	M>I		No	ClinGen ExAC TOPMed gnomAD
CA342121774 rs1385099016	270	T>I		No	ClinGen TOPMed
rs782780442 CA1058353	271	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1058352 rs782124491	273	E>G		No	ClinGen ExAC gnomAD
CA342121845 rs1553733153	273	E>Q		No	ClinGen gnomAD
CA1058351 rs587676394	274	D>N		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	275	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782734090 CA1058349	276	E>D		No	ClinGen ExAC
CA342121943 rs1388089305	276	E>G		No	ClinGen TOPMed gnomAD
rs1559160479 CA342121940	276	E>K		No	ClinGen Ensembl
CA29814112 rs954633852	277	R>G		No	ClinGen TOPMed gnomAD
CA342122103 rs61816166	281	G>E		No	ClinGen gnomAD
CA1058343 rs781922413	281	G>R		No	ClinGen ExAC gnomAD
CA29814158 rs61816166	281	G>V		No	ClinGen gnomAD
rs1262631368 CA342122124	282	T>I		No	ClinGen TOPMed gnomAD
rs1262631368 CA342122127	282	T>N		No	ClinGen TOPMed gnomAD
CA1058341 rs16827062	283	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA342122140 rs1482278382	283	K>T		No	ClinGen TOPMed
CA342122181 rs1341979312	285	A>S		No	ClinGen TOPMed
rs961873458 CA29814175	286	L>R		No	ClinGen Ensembl
CA342122210 rs1553733186	287	K>Q		No	ClinGen gnomAD
CA1058339 rs782373628	288	L>F		No	ClinGen ExAC gnomAD
rs1326690761 CA342122319	291	Q>*		No	ClinGen TOPMed
rs1311485963 CA342122362	292	H>Q		No	ClinGen TOPMed
rs782599696 CA1058337	293	L>V		No	ClinGen ExAC gnomAD
rs142625946 CA1058336	295	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs142625946 CA29814213	295	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1058311 rs782669974	296	T>I		No	ClinGen ExAC gnomAD
rs782564287 CA1058310	297	P>A		No	ClinGen ExAC gnomAD
rs781854978 CA1058309	297	P>L		No	ClinGen ExAC gnomAD
CA342123866 rs1283298115	298	P>L		No	ClinGen TOPMed
CA1058306 rs149130451	299	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1348586293 CA342123885	300	C>S		No	ClinGen TOPMed
rs199927874 CA342123930	302	S>G		No	ClinGen Ensembl
rs782804232 CA1058299	302	S>R		No	ClinGen ExAC gnomAD
rs932754285 CA29814468	303	A>T		No	ClinGen Ensembl
rs377011225 CA342123965	304	A>T		No	ClinGen ESP TOPMed
rs782107546 CA1058296	305	Y>F		No	ClinGen ExAC gnomAD
CA1058295 rs781958200	308	P>S		No	ClinGen ExAC gnomAD
rs1553733280 CA342124089	309	G>A		No	ClinGen gnomAD
CA342124117 rs868944809	311	A>T		No	ClinGen Ensembl
rs1410334400 CA342124131	311	A>V		No	ClinGen TOPMed gnomAD
CA342124144 rs1553733288	312	K>E		No	ClinGen gnomAD
CA342124216 rs1553733291	314	E>D		No	ClinGen gnomAD
CA342124242 rs1553733294	315	W>C		No	ClinGen gnomAD
rs1162955919 CA342124223	315	W>R		No	ClinGen TOPMed
CA342124289 rs1456554349	317	M>T		No	ClinGen TOPMed
rs1553733295 CA342124312	318	D>G		No	ClinGen gnomAD
CA342124343 rs1570768826	320	L>I		No	ClinGen Ensembl
CA29814517 rs782410460	321	P>H		No	ClinGen ExAC TOPMed gnomAD
CA1058291 rs782410460	321	P>L		No	ClinGen ExAC TOPMed gnomAD
rs150242444 CA1058292	321	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs150242444 CA1058293	321	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs372456821 CA1058288	322	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA1058287 rs372456821	322	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs372456821 CA1058289	322	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA342124381 rs1553733308	322	P>S		No	ClinGen gnomAD
CA1058285 rs782610175	323	N>D		No	ClinGen ExAC TOPMed gnomAD
rs782610175 CA29814529	323	N>H		No	ClinGen ExAC TOPMed gnomAD
rs1553733314 CA342124441	324	Q>R		No	ClinGen gnomAD
CA1058284 rs201942887	325	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1553733319 CA342124499	326	S>Y		No	ClinGen gnomAD
CA1058283 rs141843567	327	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs782792008 CA1058282	328	K>E		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with P0C025

2 regional properties for P0C025

Type	Name	Position	InterPro Accession
domain	NUDIX hydrolase domain	90 - 236	IPR000086
domain	Nudix motif 17 domain	92 - 234	IPR033716

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
peroxisome	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

2 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.
NADH pyrophosphatase activity	Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+.

3 GO annotations of biological process

Name	Definition
NAD catabolic process	The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH.
NADH metabolic process	The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
NADP catabolic process	The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9CWD3	Nudt17	Nucleoside diphosphate-linked moiety X motif 17	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAEVRVQLLL	SRRPESVSFA	RSVCGLLGAG	PGLGTWPIHC	SLKRGRLVLS	SRPFPGASAR
70	80	90	100	110	120
LPLQRPPFCP	FAALEERPRV	PGAELPTDRG	VDLGVAVILQ	SSDKTVLLTR	RARTLSVSPN
130	140	150	160	170	180
LWVPPGGHVE	LEEELLDGGL	RELWEESGLH	LPQGQFSWVP	LGLWESAYPP	RLSWGLPKYH
190	200	210	220	230	240
HIVLYLLVIS	QESQQQLQAR	IQPNPNEVSA	LMWLTPDVAA	AVAAAEDGTE	TPGLLPQDLP
250	260	270	280	290	300
PSVLAVELEE	DGRARPLVLH	MSTLLRMIPT	MAEDKERVST	GTKFALKLWL	QHLGRTPPPC
310	320
KSAAYLDPGP	AKEEWNMDPL	PPNQGSGK