P0AFX7

PR
Gene name
rseA (mclA, yfiJ, b2572, JW2556)
Protein name
Anti-sigma-E factor RseA
Names
Regulator of SigE, Sigma-E anti-sigma factor RseA, Sigma-E factor negative regulatory protein
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b2572
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P0AFX7

Entry ID Method Resolution Chain Position Source
1OR7 X-ray 200 A C/F 1-90 PDB
1YFN X-ray 180 A E/F/G/H 77-108 PDB
3M4W X-ray 230 A E/F/G/H 121-216 PDB
AF-P0AFX7-F1 Predicted AlphaFoldDB

No variants for P0AFX7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0AFX7

No associated diseases with P0AFX7

2 regional properties for P0AFX7

Type Name Position InterPro Accession
domain Anti sigma-E protein RseA, N-terminal 1 - 87 IPR005572
domain Anti sigma-E protein RseA, C-terminal 132 - 186 IPR005573

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Single-pass type II membrane protein
  • Following cleavage by DegS the large fragment of the protein is still in the inner membrane and retains its anti-sigma-E activity
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
sigma factor antagonist complex A protein complex which is capable of sigma factor antagonist activity.

2 GO annotations of molecular function

Name Definition
molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
sigma factor antagonist activity The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.

1 GO annotations of biological process

Name Definition
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQKEQLSALM DGETLDSELL NELAHNPEMQ KTWESYHLIR DSMRGDTPEV LHFDISSRVM
70 80 90 100 110 120
AAIEEEPVRQ PATLIPEAQP APHQWQKMPF WQKVRPWAAQ LTQMGVAACV SLAVIVGVQH
130 140 150 160 170 180
YNGQSETSQQ PETPVFNTLP MMGKASPVSL GVPSEATANN GQQQQVQEQR RRINAMLQDY
190 200 210
ELQRRLHSEQ LQFEQAQTQQ AAVQVPGIQT LGTQSQ