P0AFF8
Gene name |
nusA |
Protein name |
Transcription termination/antitermination protein NusA |
Names |
|
Species |
Escherichia coli O157:H7 |
KEGG Pathway |
ecs:ECs_4050 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0AFF8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0AFF8-F1 | Predicted | AlphaFoldDB |
No variants for P0AFF8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0AFF8 | |||||
No associated diseases with P0AFF8
7 regional properties for P0AFF8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | S1 domain | 135 - 200 | IPR003029 |
| domain | Transcription termination factor NusA | 4 - 342 | IPR010213 |
| repeat | Transcription termination factor NusA, C-terminal duplication | 365 - 414 | IPR010214-1 |
| repeat | Transcription termination factor NusA, C-terminal duplication | 440 - 489 | IPR010214-2 |
| domain | Transcription factor NusA, N-terminal | 4 - 123 | IPR013735 |
| domain | RNA-binding domain, S1 | 133 - 200 | IPR022967 |
| domain | KH domain, NusA-like | 230 - 297 | IPR025249 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| nucleotide binding | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription termination | The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template. |
| transcription antitermination | Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNKEILAVVE | AVSNEKALPR | EKIFEALESA | LATATKKKYE | QEIDVRVQID | RKSGDFDTFR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RWLVVDEVTQ | PTKEITLEAA | RYEDESLNLG | DYVEDQIESV | TFDRITTQTA | KQVIVQKVRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AERAMVVDQF | REHEGEIITG | VVKKVNRDNI | SLDLGNNAEA | VILREDMLPR | ENFRPGDRVR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GVLYSVRPEA | RGAQLFVTRS | KPEMLIELFR | IEVPEIGEEV | IEIKAAARDP | GSRAKIAVKT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NDKRIDPVGA | CVGMRGARVQ | AVSTELGGER | IDIVLWDDNP | AQFVINAMAP | ADVASIVVDE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DKHTMDIAVE | AGNLAQAIGR | NGQNVRLASQ | LSGWELNVMT | VDDLQAKHQA | EAHAAIDTFT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KYLDIDEDFA | TVLVEEGFST | LEELAYVPMK | ELLEIEGLDE | PTVEALRERA | KNALATIAQA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QEESLGDNKP | ADDLLNLEGV | DRDLAFKLAA | RGVCTLEDLA | EQGIDDLADI | EGLTDEKAGA |
| 490 | |||||
| LIMAARNICW | FGDEA |