P0AEZ2
Gene name |
metF (SF4019, S3728) |
Protein name |
5,10-methylenetetrahydrofolate reductase |
Names |
|
Species |
Shigella flexneri |
KEGG Pathway |
sfx:S3728 |
EC number |
1.5.1.54: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0AEZ2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0AEZ2-F1 | Predicted | AlphaFoldDB |
No variants for P0AEZ2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0AEZ2 | |||||
No associated diseases with P0AEZ2
No regional properties for P0AEZ2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P0AEZ2 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 1.5.1.54 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| methylenetetrahydrofolate reductase NADH activity | Catalysis of the reaction: 5-methyltetrahydrofolate + NAD + = 5,10-methylenetetrahydrofolate + NADH + H+. |
| methylenetetrahydrofolate reductase NADPH activity | Catalysis of the reaction: 5-methyltetrahydrofolate + NADP + = 5,10-methylenetetrahydrofolate + NADPH + H+. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methionine biosynthetic process | The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. |
| tetrahydrofolate interconversion | The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFFHASQRD | ALNQSLAEVQ | GQINVSFEFF | PPRTSEMEQT | LWNSIDRLSS | LKPKFVSVTY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GANSGERDRT | HSIIKGIKDR | TGLEAAPHLT | CIDATPDELR | TIARDYWNNG | IRHIVALRGD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPPGSGKPEM | YASDLVTLLK | EVADFDISVA | AYPEVHPEAK | SAQADLLNLK | RKVDAGANRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ITQFFFDVES | YLRFRDRCVS | AGIDVEIIPG | ILPVSNFKQA | KKFADMTNVR | IPAWMAQMFD |
| 250 | 260 | 270 | 280 | 290 | |
| GLDDDAETRK | LVGANIAMDM | VKILSREGVK | DFHFYTLNRA | EMSYAICHTL | GVRPGL |