P0AEJ2

PR
Gene name
entC
Protein name
Isochorismate synthase EntC
Names
Isochorismate mutase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0593
EC number
5.4.4.2: Transferring hydroxy groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

54-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P0AEJ2

Entry ID Method Resolution Chain Position Source
3HWO X-ray 230 A A/B 1-391 PDB
5JXZ X-ray 188 A A/B 1-391 PDB
5JY4 X-ray 211 A A/B 1-391 PDB
5JY8 X-ray 294 A A/B 1-391 PDB
5JZD X-ray 230 A A/B 1-391 PDB
AF-P0AEJ2-F1 Predicted AlphaFoldDB

No variants for P0AEJ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0AEJ2

No associated diseases with P0AEJ2

1 regional properties for P0AEJ2

Type Name Position InterPro Accession
domain Chorismate-utilising enzyme, C-terminal 126 - 380 IPR015890

Functions

Description
EC Number 5.4.4.2 Transferring hydroxy groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
isochorismate synthase activity Catalysis of the reaction: chorismate = isochorismate.
magnesium ion binding Binding to a magnesium (Mg) ion.

1 GO annotations of biological process

Name Definition
enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDTSLAEEVQ QTMATLAPNR FFFMSPYRSF TTSGCFARFD EPAVNGDSPD SPFQQKLAAL
70 80 90 100 110 120
FADAKAQGIK NPVMVGAIPF DPRQPSSLYI PESWQSFSRQ EKQASARRFT RSQSLNVVER
130 140 150 160 170 180
QAIPEQTTFE QMVARAAALT ATPQVDKVVL SRLIDITTDA AIDSGVLLER LIAQNPVSYN
190 200 210 220 230 240
FHVPLADGGV LLGASPELLL RKDGERFSSI PLAGSARRQP DEVLDREAGN RLLASEKDRH
250 260 270 280 290 300
EHELVTQAMK EVLRERSSEL HVPSSPQLIT TPTLWHLATP FEGKANSQEN ALTLACLLHP
310 320 330 340 350 360
TPALSGFPHQ AATQVIAELE PFDRELFGGI VGWCDSEGNG EWVVTIRCAK LRENQVRLFA
370 380 390
GAGIVPASSP LGEWRETGVK LSTMLNVFGL H