P0AEA2

PR
Gene name
csgG (b1037, JW1020)
Protein name
Curli production assembly/transport component CsgG
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1037
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P0AEA2

Entry ID Method Resolution Chain Position Source
4UV2 X-ray 280 A A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 17-277 PDB
4UV3 X-ray 359 A A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R 16-277 PDB
6L7A EM 338 A A/B/C/D/E/F/G/H/I 1-277 PDB
6L7C EM 334 A A/B/C/D/E/F/G/H/I 1-277 PDB
6LQH EM 294 A A/B/C/D/E/F/G/H/I 1-277 PDB
6LQJ EM 324 A A/B/C/D/E/F/G/H/I 1-277 PDB
6SI7 EM 340 A J/K/L/M/N/O/P/Q/R 16-277 PDB
7BRM EM 360 A A/B/C/D/E/F/G/H/I 1-277 PDB
AF-P0AEA2-F1 Predicted AlphaFoldDB

No variants for P0AEA2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0AEA2

No associated diseases with P0AEA2

No regional properties for P0AEA2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P0AEA2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell outer membrane A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
curli secretion complex A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms.
integral component of cell outer membrane The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.

4 GO annotations of biological process

Name Definition
curli assembly The process of assembly of curli, extracellular fibers produced by enteric bacteria. This process occurs outside the cell, where it is coupled to secretion across the cell outer membrane via nucleation by elements of the transporter complex.
protein secretion by the type VIII secretion system Protein secretion through the outer membrane via the mechanism used for the secretion of curli subunits.
protein transmembrane transport The process in which a protein is transported across a membrane.
single-species biofilm formation A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQRLFLLVAV MLLSGCLTAP PKEAARPTLM PRAQSYKDLT HLPAPTGKIF VSVYNIQDET
70 80 90 100 110 120
GQFKPYPASN FSTAVPQSAT AMLVTALKDS RWFIPLERQG LQNLLNERKI IRAAQENGTV
130 140 150 160 170 180
AINNRIPLQS LTAANIMVEG SIIGYESNVK SGGVGARYFG IGADTQYQLD QIAVNLRVVN
190 200 210 220 230 240
VSTGEILSSV NTSKTILSYE VQAGVFRFID YQRLLEGEVG YTSNEPVMLC LMSAIETGVI
250 260 270
FLINDGIDRG LWDLQNKAER QNDILVKYRH MSVPPES