P0AE52

PR
Gene name
bcp (b2480, JW2465)
Protein name
Peroxiredoxin Bcp
Names
Bacterioferritin comigratory protein, Thioredoxin peroxidase, Thioredoxin-dependent peroxiredoxin Bcp
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b2480
EC number
1.11.1.24: Peroxidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0AE52

Entry ID Method Resolution Chain Position Source
AF-P0AE52-F1 Predicted AlphaFoldDB

No variants for P0AE52

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0AE52

No associated diseases with P0AE52

2 regional properties for P0AE52

Type Name Position InterPro Accession
domain NADH:flavin oxidoreductase/NADH oxidase, N-terminal 8 - 337 IPR001155
domain FAD/NAD(P)-binding domain 384 - 625 IPR023753

Functions

Description
EC Number 1.11.1.24 Peroxidases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
hydroperoxide reductase activity Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol.
thioredoxin peroxidase activity Catalysis of the reaction:
thioredoxin-dependent peroxiredoxin activity Catalysis of the reaction:

3 GO annotations of biological process

Name Definition
cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell.
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNPLKAGDIA PKFSLPDQDG EQVNLTDFQG QRVLVYFYPK AMTPGCTVQA CGLRDNMDEL
70 80 90 100 110 120
KKAGVDVLGI STDKPEKLSR FAEKELLNFT LLSDEDHQVC EQFGVWGEKS FMGKTYDGIH
130 140 150
RISFLIDADG KIEHVFDDFK TSNHHDVVLN WLKEHA