P0AE01
Gene name |
trmJ |
Protein name |
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ |
Names |
TrMet(Xm32), tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase, tRNA Cm32/Um32 methyltransferase |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b2532 |
EC number |
2.1.1.200: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P0AE01
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4CND | X-ray | 150 A | A/B | 1-246 | PDB |
| 4CNE | X-ray | 190 A | A/B | 1-246 | PDB |
| 4XBO | X-ray | 260 A | A/B | 1-246 | PDB |
| AF-P0AE01-F1 | Predicted | AlphaFoldDB |
No variants for P0AE01
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0AE01 | |||||
No associated diseases with P0AE01
1 regional properties for P0AE01
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | tRNA/rRNA methyltransferase, SpoU type | 5 - 154 | IPR001537 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.200 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tRNA (cytosine-2'-O-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine. |
| tRNA (uracil-2'-O-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA nucleoside ribose methylation | The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLQNIRIVLV | ETSHTGNMGS | VARAMKTMGL | TNLWLVNPLV | KPDSQAIALA | AGASDVIGNA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HIVDTLDEAL | AGCSLVVGTS | ARSRTLPWPM | LDPRECGLKS | VAEAANTPVA | LVFGRERVGL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TNEELQKCHY | HVAIAANPEY | SSLNLAMAVQ | VIAYEVRMAW | LATQENGEQV | EHEETPYPLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DDLERFYGHL | EQTLLATGFI | RENHPGQVMN | KLRRLFTRAR | PESQELNILR | GILASIEQQN |
| KGNKAE |