P0ADF6
Gene name |
edd |
Protein name |
Phosphogluconate dehydratase |
Names |
6-phosphogluconate dehydratase, Entner-Doudoroff dehydrase |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b1851 |
EC number |
4.2.1.12: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0ADF6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0ADF6-F1 | Predicted | AlphaFoldDB |
No variants for P0ADF6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0ADF6 | |||||
No associated diseases with P0ADF6
2 regional properties for P0ADF6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site | 154 - 164 | IPR020558-1 |
| conserved_site | Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site | 505 - 516 | IPR020558-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.12 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| hydro-lyase activity | Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. |
| metal ion binding | Binding to a metal ion. |
| phosphogluconate dehydratase activity | Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| D-gluconate catabolic process | The chemical reactions and pathways resulting in the breakdown of D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose. |
| Entner-Doudoroff pathway through 6-phosphogluconate | A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNPQLLRVTN | RIIERSRETR | SAYLARIEQA | KTSTVHRSQL | ACGNLAHGFA | ACQPEDKASL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSMLRNNIAI | ITSYNDMLSA | HQPYEHYPEI | IRKALHEANA | VGQVAGGVPA | MCDGVTQGQD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GMELSLLSRE | VIAMSAAVGL | SHNMFDGALF | LGVCDKIVPG | LTMAALSFGH | LPAVFVPSGP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MASGLPNKEK | VRIRQLYAEG | KVDRMALLES | EAASYHAPGT | CTFYGTANTN | QMVVEFMGMQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPGSSFVHPD | SPLRDALTAA | AARQVTRMTG | NGNEWMPIGK | MIDEKVVVNG | IVALLATGGS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TNHTMHLVAM | ARAAGIQINW | DDFSDLSDVV | PLMARLYPNG | PADINHFQAA | GGVPVLVREL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LKAGLLHEDV | NTVAGFGLSR | YTLEPWLNNG | ELDWREGAEK | SLDSNVIASF | EQPFSHHGGT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KVLSGNLGRA | VMKTSAVPVE | NQVIEAPAVV | FESQHDVMPA | FEAGLLDRDC | VVVVRHQGPK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ANGMPELHKL | MPPLGVLLDR | CFKIALVTDG | RLSGASGKVP | SAIHVTPEAY | DGGLLAKVRD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GDIIRVNGQT | GELTLLVDEA | ELAAREPHIP | DLSASRVGTG | RELFSALREK | LSGAEQGATC |
| ITF |