P0ACS9

PR
Gene name
acrR (ybaH, b0464, JW0453)
Protein name
HTH-type transcriptional regulator AcrR
Names
Potential acrAB operon repressor
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0464
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P0ACS9

Entry ID Method Resolution Chain Position Source
2QOP X-ray 255 A A 1-215 PDB
3BCG X-ray 248 A A/B 1-215 PDB
AF-P0ACS9-F1 Predicted AlphaFoldDB

No variants for P0ACS9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0ACS9

No associated diseases with P0ACS9

3 regional properties for P0ACS9

Type Name Position InterPro Accession
domain DNA-binding HTH domain, TetR-type 10 - 70 IPR001647
domain Transcription regulator MAATS, C-terminal 84 - 202 IPR013572
conserved_site DNA-binding HTH domain, TetR-type, conserved site 28 - 58 IPR023772

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
toxic substance binding Binding to a toxic substance, a poisonous substance that causes damage to biological systems.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

3 GO annotations of biological process

Name Definition
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MARKTKQEAQ ETRQHILDVA LRLFSQQGVS STSLGEIAKA AGVTRGAIYW HFKDKSDLFS
70 80 90 100 110 120
EIWELSESNI GELELEYQAK FPGDPLSVLR EILIHVLEST VTEERRRLLM EIIFHKCEFV
130 140 150 160 170 180
GEMAVVQQAQ RNLCLESYDR IEQTLKHCIE AKMLPADLMT RRAAIIMRGY ISGLMENWLF
190 200 210
APQSFDLKKE ARDYVAILLE MYLLCPTLRN PATNE