P0ACB5

PR
Gene name
hemG
Protein name
Protoporphyrinogen IX dehydrogenase [quinone]
Names
Protoporphyrinogen IX dehydrogenase [menaquinone], Protoporphyrinogen IX dehydrogenase [ubiquinone], Protoporphyrinogen oxidase, PPO
Species
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG Pathway
ecc:c4797
EC number
1.3.5.3: With a quinone or related compound as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

50-137 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0ACB5

Entry ID Method Resolution Chain Position Source
AF-P0ACB5-F1 Predicted AlphaFoldDB

No variants for P0ACB5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0ACB5

No associated diseases with P0ACB5

3 regional properties for P0ACB5

Type Name Position InterPro Accession
conserved_site Flavodoxin, conserved site 5 - 21 IPR001226
domain Flavodoxin/nitric oxide synthase 3 - 172 IPR008254
domain Flavodoxin domain 4 - 152 IPR026816

Functions

Description
EC Number 1.3.5.3 With a quinone or related compound as acceptor
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
electron transfer activity Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
menaquinone-dependent protoporphyrinogen oxidase activity Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone.
oxygen-dependent protoporphyrinogen oxidase activity Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX.

1 GO annotations of biological process

Name Definition
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTLILFSTR DGQTREIASY LASELKELGI QADVANVHRI EEPQWENYDR VVIGASIRYG
70 80 90 100 110 120
HYHSAFQEFV KKHATRLNSM PSAFYSVNLV ARKPEKRTPQ TNSYARKFLM NSQWRPDRCA
130 140 150 160 170 180
VIAGALRYPR YRWYDRFMIK LIMKMSGGET DTRKEVVYTD WEQVANFARE IAHLTDKPTL
K