P0ACB2

PR
Gene name
hemB (ncf, b0369, JW0361)
Protein name
Delta-aminolevulinic acid dehydratase
Names
ALAD, ALADH, Porphobilinogen synthase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0369
EC number
4.2.1.24: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

54-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P0ACB2

Entry ID Method Resolution Chain Position Source
1B4E X-ray 200 A A 2-324 PDB
1I8J X-ray 190 A A/B 2-324 PDB
1L6S X-ray 170 A A/B 2-324 PDB
1L6Y X-ray 190 A A/B 2-324 PDB
5MHB X-ray 210 A A 1-324 PDB
AF-P0ACB2-F1 Predicted AlphaFoldDB

No variants for P0ACB2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0ACB2

No associated diseases with P0ACB2

4 regional properties for P0ACB2

Type Name Position InterPro Accession
domain Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase 171 - 307 IPR006151
domain Glutamyl-tRNA reductase, N-terminal 6 - 156 IPR015895
domain Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain 321 - 418 IPR015896
conserved_site Glutamyl-tRNA reductase, conserved site 99 - 122 IPR018214

Functions

Description
EC Number 4.2.1.24 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
porphobilinogen synthase activity Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDLIQRPRR LRKSPALRAM FEETTLSLND LVLPIFVEEE IDDYKAVEAM PGVMRIPEKH
70 80 90 100 110 120
LAREIERIAN AGIRSVMTFG ISHHTDETGS DAWREDGLVA RMSRICKQTV PEMIVMSDTC
130 140 150 160 170 180
FCEYTSHGHC GVLCEHGVDN DATLENLGKQ AVVAAAAGAD FIAPSAAMDG QVQAIRQALD
190 200 210 220 230 240
AAGFKDTAIM SYSTKFASSF YGPFREAAGS ALKGDRKSYQ MNPMNRREAI RESLLDEAQG
250 260 270 280 290 300
ADCLMVKPAG AYLDIVRELR ERTELPIGAY QVSGEYAMIK FAALAGAIDE EKVVLESLGS
310 320
IKRAGADLIF SYFALDLAEK KILR