P0AC77
Gene name |
waaA (kdtA, Z5057, ECs4508) |
Protein name |
3-deoxy-D-manno-octulosonic acid transferase |
Names |
Kdo transferase, Bifunctional Kdo transferase, Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase, Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase |
Species |
Escherichia coli O157:H7 |
KEGG Pathway |
ecs:ECs_4508 |
EC number |
2.4.99.12: Transferring other glycosyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0AC77
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0AC77-F1 | Predicted | AlphaFoldDB |
No variants for P0AC77
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0AC77 | |||||
No associated diseases with P0AC77
1 regional properties for P0AC77
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 3-deoxy-D-manno-octulosonic-acid transferase, N-terminal | 33 - 211 | IPR007507 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.99.12 | Transferring other glycosyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| Kdo transferase activity | Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| Kdo2-lipid A biosynthetic process | The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component. |
| lipopolysaccharide core region biosynthetic process | The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLELLYTALL | YLIQPLIWIR | LWVRGRKAPA | YRKRWGERYG | FYRHPLKPGG | IMLHSVSVGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLAAIPLVRA | LRHRYPDLPI | TVTTMTPTGS | ERVQSAFGKD | VQHVYLPYDL | PDALNRFLNK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VDPKLVLIME | TELWPNLIAA | LHKRKIPLVI | ANARLSARSA | AGYAKLGKFV | RRLLRRITLI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AAQNEEDGAR | FVALGAKNNQ | VTVTGSLKFD | ISVTPQLAAK | AVTLRRQWAP | HRPVWIATST |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HEGEESVVIA | AHQALLQQFP | NLLLILVPRH | PERFPDAINL | VRQAGLSYIT | RSSGEVPSTS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TQVVVGDTMG | ELMLLYGIAD | LAFVGGSLVE | RGGHNPLEAA | AHAIPVLMGP | HTFNFKDICA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RLEQASGLIT | VTDATTLAKE | VSSLLTDADY | RSFYGRHAVE | VLYQNQGALQ | RLLQLLEPYL |
| PPKTH |