P0AB89

PR
Gene name
purB (b1131, JW1117)
Protein name
Adenylosuccinate lyase
Names
ASL, Adenylosuccinase, ASase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1131
EC number
4.3.2.2: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

142-214 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P0AB89

Entry ID Method Resolution Chain Position Source
2PTQ X-ray 200 A A/B 1-456 PDB
2PTR X-ray 185 A A/B 1-456 PDB
2PTS X-ray 200 A A 1-456 PDB
AF-P0AB89-F1 Predicted AlphaFoldDB

No variants for P0AB89

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0AB89

No associated diseases with P0AB89

3 regional properties for P0AB89

Type Name Position InterPro Accession
domain Adenylosuccinate lyase PurB, C-terminal 331 - 445 IPR013539
conserved_site Fumarate lyase, conserved site 294 - 303 IPR020557
domain Fumarate lyase, N-terminal 14 - 312 IPR022761

Functions

Description
EC Number 4.3.2.2 Lyases acting on amides, amidines, etc
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
guanosine tetraphosphate binding Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions.
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.

3 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELSSLTAVS PVDGRYGDKV SALRGIFSEY GLLKFRVQVE VRWLQKLAAH AAIKEVPAFA
70 80 90 100 110 120
ADAIGYLDAI VASFSEEDAA RIKTIERTTN HDVKAVEYFL KEKVAEIPEL HAVSEFIHFA
130 140 150 160 170 180
CTSEDINNLS HALMLKTARD EVILPYWRQL IDGIKDLAVQ YRDIPLLSRT HGQPATPSTI
190 200 210 220 230 240
GKEMANVAYR MERQYRQLNQ VEILGKINGA VGNYNAHIAA YPEVDWHQFS EEFVTSLGIQ
250 260 270 280 290 300
WNPYTTQIEP HDYIAELFDC VARFNTILID FDRDVWGYIA LNHFKQKTIA GEIGSSTMPH
310 320 330 340 350 360
KVNPIDFENS EGNLGLSNAV LQHLASKLPV SRWQRDLTDS TVLRNLGVGI GYALIAYQST
370 380 390 400 410 420
LKGVSKLEVN RDHLLDELDH NWEVLAEPIQ TVMRRYGIEK PYEKLKELTR GKRVDAEGMK
430 440 450
QFIDGLALPE EEKARLKAMT PANYIGRAIT MVDELK