P0AA90
Gene name |
dosC (Z2219, ECs2095) |
Protein name |
Diguanylate cyclase DosC |
Names |
DGC, Direct oxygen-sensing cyclase |
Species |
Escherichia coli O157:H7 |
KEGG Pathway |
ecs:ECs_2095 |
EC number |
2.7.7.65: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0AA90
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0AA90-F1 | Predicted | AlphaFoldDB |
No variants for P0AA90
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0AA90 | |||||
No associated diseases with P0AA90
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.65 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| diguanylate cyclase activity | Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| metal ion binding | Binding to a metal ion. |
| oxygen binding | Binding to oxygen (O2). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEMYFKRMKD | EWTGLVEQAD | PPIRAKAAEI | AVAHAHYLSI | EFYRIVRIDP | HAEEFLSNEQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VERQLKSAME | RWIINVLSAQ | VDDVERLIQI | QHTVAEVHAR | IGIPVEIVEM | GFRVLKKILY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PVIFSSDYSA | AEKLQVYHFS | INSIDIAMEV | MTRAFTFSDS | SASKEDENYR | IFSLLENAEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EKERQIASIL | SWEIDIIYKI | LLDSDLGSSL | PLSQADFGLW | FNHKGRHYFS | GIAEVGHISR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LIQDFDGIFN | QTMRNTRNLN | NRSLRVKFLL | QIRNTVSQII | TLLRELFEEV | SRHEVGMDVL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TKLLNRRFLP | TIFKREIAHA | NRTGTPLSVL | IIDVDKFKEI | NDTWGHNTGD | EILRKVSQAF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YDNVRSSDYV | FRYGGDEFII | VLTEASENET | LRTAERIRSR | VEKTKLKAAN | GEDIALSLSI |
| 430 | 440 | 450 | |||
| GAAMFNGHPD | YERLIQIADE | ALYIAKRRGR | NRVELWKASL |