P0AA89

PR
Gene name
dosC (dgcO)
Protein name
Diguanylate cyclase DosC
Names
DGC, Direct oxygen-sensing cyclase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1490
EC number
2.7.7.65: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

134-207 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P0AA89

Entry ID Method Resolution Chain Position Source
4ZVA X-ray 200 A A/B 8-170 PDB
4ZVB X-ray 240 A A/B/C/D 1-155 PDB
4ZVC X-ray 150 A A/B 173-298 PDB
4ZVD X-ray 190 A A/B 173-298 PDB
4ZVE X-ray 120 A A 297-460 PDB
4ZVF X-ray 115 A A 297-460 PDB
4ZVG X-ray 220 A A/B 297-460 PDB
4ZVH X-ray 330 A A/B 297-460 PDB
AF-P0AA89-F1 Predicted AlphaFoldDB

No variants for P0AA89

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0AA89

No associated diseases with P0AA89

3 regional properties for P0AA89

Type Name Position InterPro Accession
domain GGDEF domain 283 - 458 IPR000160
domain Diguanylate cyclase DosC, globin sensor domain 7 - 153 IPR039435
domain Globin-sensor domain 27 - 155 IPR044398

Functions

Description
EC Number 2.7.7.65 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
carbon monoxide binding Binding to carbon monoxide (CO).
diguanylate cyclase activity Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+).
GTP binding Binding to GTP, guanosine triphosphate.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding Binding to a metal ion.
oxygen binding Binding to oxygen (O2).

3 GO annotations of biological process

Name Definition
cell adhesion involved in single-species biofilm formation The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
negative regulation of bacterial-type flagellum-dependent cell motility Any process that stops, prevents or reduces the frequency, rate or extent of bacterial-type flagellum-dependent cell motility.
response to oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEMYFKRMKD EWTGLVEQAD PPIRAKAAEI AVAHAHYLSI EFYRIVRIDP HAEEFLSNEQ
70 80 90 100 110 120
VERQLKSAME RWIINVLSAQ VDDVERLIQI QHTVAEVHAR IGIPVEIVEM GFRVLKKILY
130 140 150 160 170 180
PVIFSSDYSA AEKLQVYHFS INSIDIAMEV MTRAFTFSDS SASKEDENYR IFSLLENAEE
190 200 210 220 230 240
EKERQIASIL SWEIDIIYKI LLDSDLGSSL PLSQADFGLW FNHKGRHYFS GIAEVGHISR
250 260 270 280 290 300
LIQDFDGIFN QTMRNTRNLN NRSLRVKFLL QIRNTVSQII TLLRELFEEV SRHEVGMDVL
310 320 330 340 350 360
TKLLNRRFLP TIFKREIAHA NRTGTPLSVL IIDVDKFKEI NDTWGHNTGD EILRKVSQAF
370 380 390 400 410 420
YDNVRSSDYV FRYGGDEFII VLTEASENET LRTAERIRSR VEKTKLKAAN GEDIALSLSI
430 440 450
GAAMFNGHPD YERLIQIADE ALYIAKRRGR NRVELWKASL