P0A9J4

PR
Gene name
panE (apbA, b0425, JW0415)
Protein name
2-dehydropantoate 2-reductase
Names
Ketopantoate reductase, KPA reductase, KPR
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0425
EC number
1.1.1.169: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

68-146 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P0A9J4

Entry ID Method Resolution Chain Position Source
1KS9 X-ray 170 A A 1-291 PDB
1YJQ X-ray 209 A A 1-303 PDB
1YON X-ray 195 A A 1-303 PDB
2OFP X-ray 230 A A/B 1-303 PDB
AF-P0A9J4-F1 Predicted AlphaFoldDB

No variants for P0A9J4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A9J4

No associated diseases with P0A9J4

2 regional properties for P0A9J4

Type Name Position InterPro Accession
domain Ketopantoate reductase, N-terminal domain 3 - 143 IPR013332
domain Ketopantoate reductase, C-terminal domain 168 - 289 IPR013752

Functions

Description
EC Number 1.1.1.169 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
2-dehydropantoate 2-reductase activity Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

1 GO annotations of biological process

Name Definition
pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKITVLGCGA LGQLWLTALC KQGHEVQGWL RVPQPYCSVN LVETDGSIFN ESLTANDPDF
70 80 90 100 110 120
LATSDLLLVT LKAWQVSDAV KSLASTLPVT TPILLIHNGM GTIEELQNIQ QPLLMGTTTH
130 140 150 160 170 180
AARRDGNVII HVANGITHIG PARQQDGDYS YLADILQTVL PDVAWHNNIR AELWRKLAVN
190 200 210 220 230 240
CVINPLTAIW NCPNGELRHH PQEIMQICEE VAAVIEREGH HTSAEDLRDY VMQVIDATAE
250 260 270 280 290 300
NISSMLQDIR ALRHTEIDYI NGFLLRRARA HGIAVPENTR LFEMVKRKES EYERIGTGLP
RPW