P0A855

PR
Gene name
tolB
Protein name
Tol-Pal system protein TolB
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0740
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

41-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P0A855

Entry ID Method Resolution Chain Position Source
1C5K X-ray 200 A A 1-430 PDB
1CRZ X-ray 195 A A 28-430 PDB
2HQS X-ray 150 A A/B/D/F 23-430 PDB
2IVZ X-ray 200 A A/B/C/D 1-430 PDB
2W8B X-ray 186 A A/B/D/F 22-430 PDB
3IAX X-ray 260 A A 1-430 PDB
7NST EM 370 A E 1-430 PDB
7NSU EM 470 A E 1-430 PDB
AF-P0A855-F1 Predicted AlphaFoldDB

No variants for P0A855

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A855

No associated diseases with P0A855

5 regional properties for P0A855

Type Name Position InterPro Accession
domain TolB, N-terminal 24 - 121 IPR007195
repeat WD40-like beta propeller 199 - 223 IPR011659-1
repeat WD40-like beta propeller 237 - 272 IPR011659-2
repeat WD40-like beta propeller 281 - 315 IPR011659-3
repeat WD40-like beta propeller 369 - 396 IPR011659-4

Functions

Description
EC Number
Subcellular Localization
  • Periplasm
  • Partially associated with the outer membrane through a specific interaction with Pal (PubMed:7744736)
  • Accumulates at cell constriction sites
  • Recruitment to the division site is dependent on FtsN activity (PubMed:17233825)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
periplasmic space The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
protein domain specific binding Binding to a specific domain of a protein.
protein-containing complex binding Binding to a macromolecular complex.

7 GO annotations of biological process

Name Definition
bacteriocin transport The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain.
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cellular response to bacteriocin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of membrane invagination Any process that modulates the frequency, rate or extent of membrane invagination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKQALRVAFG FLILWASVLH AEVRIVIDSG VDSGRPIGVV PFQWAGPGAA PEDIGGIVAA
70 80 90 100 110 120
DLRNSGKFNP LDRARLPQQP GSAQEVQPAA WSALGIDAVV VGQVTPNPDG SYNVAYQLVD
130 140 150 160 170 180
TGGAPGTVLA QNSYKVNKQW LRYAGHTASD EVFEKLTGIK GAFRTRIAYV VQTNGGQFPY
190 200 210 220 230 240
ELRVSDYDGY NQFVVHRSPQ PLMSPAWSPD GSKLAYVTFE SGRSALVIQT LANGAVRQVA
250 260 270 280 290 300
SFPRHNGAPA FSPDGSKLAF ALSKTGSLNL YVMDLASGQI RQVTDGRSNN TEPTWFPDSQ
310 320 330 340 350 360
NLAFTSDQAG RPQVYKVNIN GGAPQRITWE GSQNQDADVS SDGKFMVMVS SNGGQQHIAK
370 380 390 400 410 420
QDLATGGVQV LSSTFLDETP SLAPNGTMVI YSSSQGMGSV LNLVSTDGRF KARLPATDGQ
VKFPAWSPYL