P0A7G6

PR
Gene name
recA
Protein name
Protein RecA
Names
Recombinase A
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b2699
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

25 structures for P0A7G6

Entry ID Method Resolution Chain Position Source
1AA3 NMR - A 269-331 PDB
1N03 EM 2000 A A/B/C/D/E/F/G 2-353 PDB
1REA X-ray 270 A A 2-353 PDB
1U94 X-ray 190 A A 2-353 PDB
1U98 X-ray 200 A A 2-353 PDB
1U99 X-ray 260 A A 2-353 PDB
1XMS X-ray 210 A A 2-353 PDB
1XMV X-ray 190 A A 2-353 PDB
2REB X-ray 230 A A 2-353 PDB
2REC EM - A/B/C/D/E/F 1-353 PDB
3CMT X-ray 315 A A/D 2-335 PDB
3CMU X-ray 420 A A 2-335 PDB
3CMV X-ray 430 A A/B/C/D/E/F/G/H 2-335 PDB
3CMW X-ray 280 A A/C 2-335 PDB
3CMX X-ray 340 A A/D 2-335 PDB
4TWZ X-ray 280 A A 2-353 PDB
7JY6 EM 250 A A/B/C/D/E/F/G/H/I 1-334 PDB
7JY7 EM 290 A A/B/C/D/E/F/G/H/I 1-334 PDB
7JY8 EM 250 A A/B/C/D/E/F/G/H/I 1-334 PDB
7JY9 EM 280 A A/B/C/D/E/F/G/H/I 1-334 PDB
7YWA EM 326 A F/G 1-353 PDB
8GMT EM 331 A F/G 1-353 PDB
8GMU EM 278 A F/G 1-353 PDB
8TRG EM 293 A A/B/C/D/E/F/G/H 1-353 PDB
AF-P0A7G6-F1 Predicted AlphaFoldDB

No variants for P0A7G6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A7G6

No associated diseases with P0A7G6

4 regional properties for P0A7G6

Type Name Position InterPro Accession
domain AAA+ ATPase domain 59 - 230 IPR003593
conserved_site DNA recombination/repair protein RecA, conserved site 215 - 223 IPR020584
domain DNA recombination and repair protein RecA, monomer-monomer interface 201 - 274 IPR020587
domain DNA recombination and repair protein RecA-like, ATP-binding domain 37 - 196 IPR020588

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA polymerase V complex A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
single-stranded DNA binding Binding to single-stranded DNA.

8 GO annotations of biological process

Name Definition
cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
homologous recombination A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules.
recombinational repair A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.
response to ionizing radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
SOS response An error-prone process for repairing damaged microbial DNA.
translesion synthesis The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAIDENKQKA LAAALGQIEK QFGKGSIMRL GEDRSMDVET ISTGSLSLDI ALGAGGLPMG
70 80 90 100 110 120
RIVEIYGPES SGKTTLTLQV IAAAQREGKT CAFIDAEHAL DPIYARKLGV DIDNLLCSQP
130 140 150 160 170 180
DTGEQALEIC DALARSGAVD VIVVDSVAAL TPKAEIEGEI GDSHMGLAAR MMSQAMRKLA
190 200 210 220 230 240
GNLKQSNTLL IFINQIRMKI GVMFGNPETT TGGNALKFYA SVRLDIRRIG AVKEGENVVG
250 260 270 280 290 300
SETRVKVVKN KIAAPFKQAE FQILYGEGIN FYGELVDLGV KEKLIEKAGA WYSYKGEKIG
310 320 330 340 350
QGKANATAWL KDNPETAKEI EKKVRELLLS NPNSTPDFSV DDSEGVAETN EDF