P0A7C2
Gene name |
lexA |
Protein name |
LexA repressor |
Names |
|
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b4043 |
EC number |
3.4.21.88: Serine endopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
12 structures for P0A7C2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1JHC | X-ray | 200 A | A | 68-202 | PDB |
| 1JHE | X-ray | 250 A | A/B | 68-202 | PDB |
| 1JHF | X-ray | 180 A | A/B | 1-202 | PDB |
| 1JHH | X-ray | 210 A | A/B | 1-202 | PDB |
| 1LEA | NMR | - | A | 1-84 | PDB |
| 1LEB | NMR | - | A | 1-84 | PDB |
| 3JSO | X-ray | 229 A | A/B | 1-202 | PDB |
| 3JSP | X-ray | 290 A | A/B | 1-202 | PDB |
| 3K3R | X-ray | 320 A | E/F | 1-202 | PDB |
| 7B5G | X-ray | 240 A | A/C/E/G | 1-202 | PDB |
| 8TRG | EM | 293 A | I/J | 1-202 | PDB |
| AF-P0A7C2-F1 | Predicted | AlphaFoldDB |
1 variants for P0A7C2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 85 | G>D | lexA3, resistant to cleavage. Increased sensitivity to hydroxyurea [UniProt] | No |
No associated diseases with P0A7C2
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.21.88 | Serine endopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| protein-DNA complex | A macromolecular complex containing both protein and DNA molecules. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription repressor activity | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. |
| identical protein binding | Binding to an identical protein or proteins. |
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| SOS response | An error-prone process for repairing damaged microbial DNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKALTARQQE | VFDLIRDHIS | QTGMPPTRAE | IAQRLGFRSP | NAAEEHLKAL | ARKGVIEIVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GASRGIRLLQ | EEEEGLPLVG | RVAAGEPLLA | QQHIEGHYQV | DPSLFKPNAD | FLLRVSGMSM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDIGIMDGDL | LAVHKTQDVR | NGQVVVARID | DEVTVKRLKK | QGNKVELLPE | NSEFKPIVVD |
| 190 | 200 | ||||
| LRQQSFTIEG | LAVGVIRNGD | WL |