P0A715

PR
Gene name
kdsA (b1215, JW1206)
Protein name
2-dehydro-3-deoxyphosphooctonate aldolase
Names
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1215
EC number
2.5.1.55: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

28-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

12 structures for P0A715

Entry ID Method Resolution Chain Position Source
1D9E X-ray 240 A A/B/C/D 1-284 PDB
1G7U X-ray 280 A A 1-284 PDB
1G7V X-ray 240 A A 1-284 PDB
1GG0 X-ray 300 A A 1-284 PDB
1PHQ X-ray 270 A A 1-284 PDB
1PHW X-ray 236 A A 1-284 PDB
1PL9 X-ray 290 A A 1-284 PDB
1Q3N X-ray 270 A A 1-284 PDB
1X6U X-ray 270 A A 1-284 PDB
1X8F X-ray 240 A A 1-284 PDB
6U57 X-ray 280 A A 1-284 PDB
AF-P0A715-F1 Predicted AlphaFoldDB

No variants for P0A715

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A715

No associated diseases with P0A715

1 regional properties for P0A715

Type Name Position InterPro Accession
domain DAHP synthetase I/KDSA 10 - 274 IPR006218

Functions

Description
EC Number 2.5.1.55 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

2 GO annotations of molecular function

Name Definition
3-deoxy-8-phosphooctulonate synthase activity Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate.
identical protein binding Binding to an identical protein or proteins.

2 GO annotations of biological process

Name Definition
keto-3-deoxy-D-manno-octulosonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria.
monosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKQKVVSIGD INVANDLPFV LFGGMNVLES RDLAMRICEH YVTVTQKLGI PYVFKASFDK
70 80 90 100 110 120
ANRSSIHSYR GPGLEEGMKI FQELKQTFGV KIITDVHEPS QAQPVADVVD VIQLPAFLAR
130 140 150 160 170 180
QTDLVEAMAK TGAVINVKKP QFVSPGQMGN IVDKFKEGGN EKVILCDRGA NFGYDNLVVD
190 200 210 220 230 240
MLGFSIMKKV SGNSPVIFDV THALQCRDPF GAASGGRRAQ VAELARAGMA VGLAGLFIEA
250 260 270 280
HPDPEHAKCD GPSALPLAKL EPFLKQMKAI DDLVKGFEEL DTSK