P0A708

PR
Gene name
infC
Protein name
Translation initiation factor IF-3
Names
Species
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG Pathway
ecc:c2115
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0A708

Entry ID Method Resolution Chain Position Source
AF-P0A708-F1 Predicted AlphaFoldDB

No variants for P0A708

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A708

No associated diseases with P0A708

3 regional properties for P0A708

Type Name Position InterPro Accession
conserved_site Translation initiation factor 3, conserved site 66 - 79 IPR019813
domain Translation initiation factor 3, N-terminal 15 - 84 IPR019814
domain Translation initiation factor 3, C-terminal 91 - 177 IPR019815

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
translation initiation complex A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.

3 GO annotations of molecular function

Name Definition
methionyl-initiator methionine tRNA binding Binding to methionine-initator methionine tRNA.
ribosomal small subunit binding Binding to a small ribosomal subunit.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

4 GO annotations of biological process

Name Definition
formation of translation preinitiation complex The joining of the small ribosomal subunit, ternary complex, and mRNA.
positive regulation of formation of translation preinitiation complex Any process that activates or increases the frequency, rate or extent of formation of translation preinitiation complex.
ribosome disassembly The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKGGKRVQTA RPNRINGEIR AQEVRLTGLE GEQLGIVSLR EALEKAEEAG VDLVEISPNA
70 80 90 100 110 120
EPPVCRIMDY GKFLYEKSKS SKEQKKKQKV IQVKEIKFRP GTDEGDYQVK LRSLIRFLEE
130 140 150 160 170
GDKAKITLRF RGREMAHQQI GMEVLNRVKD DLQELAVVES FPTKIEGRQM IMVLAPKKKQ