P0A6P5
Gene name |
der (engA, yfgK, b2511, JW5403) |
Protein name |
GTPase Der |
Names |
Double era-like domain protein, GTP-binding protein EngA |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b2511 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P0A6P5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3J8G | EM | 500 A | X | 1-490 | PDB |
| AF-P0A6P5-F1 | Predicted | AlphaFoldDB |
No variants for P0A6P5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0A6P5 | |||||
No associated diseases with P0A6P5
7 regional properties for P0A6P5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 4 - 157 | IPR005225-1 |
| domain | Small GTP-binding protein domain | 203 - 368 | IPR005225-2 |
| domain | GTP binding domain | 5 - 119 | IPR006073-1 |
| domain | GTP binding domain | 205 - 322 | IPR006073-2 |
| domain | EngA-type guanine nucleotide-binding (G) domain | 3 - 166 | IPR031166-1 |
| domain | EngA-type guanine nucleotide-binding (G) domain | 203 - 376 | IPR031166-2 |
| domain | GTPase Der, C-terminal KH-domain-like | 378 - 458 | IPR032859 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| guanosine tetraphosphate binding | Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions. |
| ribosomal large subunit binding | Binding to a large ribosomal subunit. |
| ribosome binding | Binding to a ribosome. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ribosomal large subunit assembly | The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVPVVALVGR | PNVGKSTLFN | RLTRTRDALV | ADFPGLTRDR | KYGRAEIEGR | EFICIDTGGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DGTEDGVETR | MAEQSLLAIE | EADVVLFMVD | ARAGLMPADE | AIAKHLRSRE | KPTFLVANKT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DGLDPDQAVV | DFYSLGLGEI | YPIAASHGRG | VLSLLEHVLL | PWMEDLAPQE | EVDEDAEYWA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QFEAEENGEE | EEEDDFDPQS | LPIKLAIVGR | PNVGKSTLTN | RILGEERVVV | YDMPGTTRDS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IYIPMERDGR | EYVLIDTAGV | RKRGKITDAV | EKFSVIKTLQ | AIEDANVVML | VIDAREGISD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QDLSLLGFIL | NSGRSLVIVV | NKWDGLSQEV | KEQVKETLDF | RLGFIDFARV | HFISALHGSG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VGNLFESVRE | AYDSSTRRVG | TSMLTRIMTM | AVEDHQPPLV | RGRRVKLKYA | HAGGYNPPIV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VIHGNQVKDL | PDSYKRYLMN | YFRKSLDVMG | SPIRIQFKEG | ENPYANKRNT | LTPTQMRKRK |
| RLMKHIKKNK |