P0A6L7

PR
Gene name
uxaB (b1521, JW1514)
Protein name
Altronate oxidoreductase
Names
Tagaturonate dehydrogenase, Tagaturonate reductase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1521
EC number
1.1.1.58: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0A6L7

Entry ID Method Resolution Chain Position Source
AF-P0A6L7-F1 Predicted AlphaFoldDB

No variants for P0A6L7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A6L7

No associated diseases with P0A6L7

2 regional properties for P0A6L7

Type Name Position InterPro Accession
domain Mannitol dehydrogenase, C-terminal 203 - 458 IPR013118
domain Mannitol dehydrogenase, N-terminal 17 - 172 IPR013131

Functions

Description
EC Number 1.1.1.58 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
mannitol-1-phosphate 5-dehydrogenase activity Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+.
tagaturonate reductase activity Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH.

2 GO annotations of biological process

Name Definition
D-galacturonate catabolic process The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid.
mannitol catabolic process The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTLNRRDFP GAQYPERIIQ FGEGNFLRAF VDWQIDLLNE HTDLNSGVVV VRPIETSFPP
70 80 90 100 110 120
SLSTQDGLYT TIIRGLNEKG EAVSDARLIR SVNREISVYS EYDEFLKLAH NPEMRFVFSN
130 140 150 160 170 180
TTEAGISYHA GDKFDDAPAV SYPAKLTRLL FERFSHFNGA LDKGWIIIPC ELIDYNGDAL
190 200 210 220 230 240
RELVLRYAQE WALPEAFIQW LDQANSFCST LVDRIVTGYP RDEVAKLEEE LGYHDGFLDT
250 260 270 280 290 300
AEHFYLFVIQ GPKSLATELR LDKYPLNVLI VDDIKPYKER KVAILNGAHT ALVPVAFQAG
310 320 330 340 350 360
LDTVGEAMND AEICAFVEKA IYEEIIPVLD LPRDELESFA SAVTGRFRNP YIKHQLLSIA
370 380 390 400 410 420
LNGMTKFRTR ILPQLLAGQK ANGTLPARLT FALAALIAFY RGERNGETYP VQDDAHWLER
430 440 450 460 470 480
YQQLWSQHRD RVIGTQELVA IVLAEKDHWE QDLTQVPGLV EQVANDLDAI LEKGMREAVR
PLC