P0A6L0

PR
Gene name
deoC
Protein name
Deoxyribose-phosphate aldolase
Names
DERA, 2-deoxy-D-ribose 5-phosphate aldolase, Phosphodeoxyriboaldolase, Deoxyriboaldolase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b4381
EC number
4.1.2.4: Aldehyde-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

12 structures for P0A6L0

Entry ID Method Resolution Chain Position Source
1JCJ X-ray 110 A A/B 1-259 PDB
1JCL X-ray 105 A A/B 1-259 PDB
1KTN X-ray 140 A A/B 1-250 PDB
1P1X X-ray 099 A A/B 1-259 PDB
5EKY X-ray 110 A A 1-259 PDB
5EL1 X-ray 125 A A 1-259 PDB
5EMU X-ray 150 A A 1-259 PDB
6Z9H X-ray 172 A A/B 2-259 PDB
6Z9I X-ray 186 A A/B 1-250 PDB
6Z9J X-ray 150 A A/B 1-250 PDB
7P75 X-ray 123 A AAA/BBB 1-259 PDB
AF-P0A6L0-F1 Predicted AlphaFoldDB

No variants for P0A6L0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A6L0

No associated diseases with P0A6L0

No regional properties for P0A6L0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P0A6L0

Functions

Description
EC Number 4.1.2.4 Aldehyde-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
deoxyribose-phosphate aldolase activity Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

5 GO annotations of biological process

Name Definition
carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
deoxyribose phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose.
nucleobase-containing small molecule interconversion The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDLKASSLR ALKLMDLTTL NDDDTDEKVI ALCHQAKTPV GNTAAICIYP RFIPIARKTL
70 80 90 100 110 120
KEQGTPEIRI ATVTNFPHGN DDIDIALAET RAAIAYGADE VDVVFPYRAL MAGNEQVGFD
130 140 150 160 170 180
LVKACKEACA AANVLLKVII ETGELKDEAL IRKASEISIK AGADFIKTST GKVAVNATPE
190 200 210 220 230 240
SARIMMEVIR DMGVEKTVGF KPAGGVRTAE DAQKYLAIAD ELFGADWADA RHYRFGASSL
250
LASLLKALGH GDGKSASSY