P0A6I3
Gene name |
coaA (panK, rts, b3974, JW3942) |
Protein name |
Pantothenate kinase |
Names |
Pantothenic acid kinase, Rts protein |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b3974 |
EC number |
2.7.1.33: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P0A6I3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1ESM | X-ray | 250 A | A/B/C/D | 1-316 | PDB |
| 1ESN | X-ray | 260 A | A/B/C/D | 1-316 | PDB |
| 1SQ5 | X-ray | 220 A | A/B/C/D | 9-316 | PDB |
| AF-P0A6I3-F1 | Predicted | AlphaFoldDB |
No variants for P0A6I3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0A6I3 | |||||
No associated diseases with P0A6I3
1 regional properties for P0A6I3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphoribulokinase/uridine kinase | 90 - 245 | IPR006083 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.33 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| pantetheine kinase activity | Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate. |
| pantothenate kinase activity | Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| coenzyme A biosynthetic process | The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96BW1 | UPRT | Uracil phosphoribosyltransferase homolog | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSIKEQTLMT | PYLQFDRNQW | AALRDSVPMT | LSEDEIARLK | GINEDLSLEE | VAEIYLPLSR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLNFYISSNL | RRQAVLEQFL | GTNGQRIPYI | ISIAGSVAVG | KSTTARVLQA | LLSRWPEHRR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VELITTDGFL | HPNQVLKERG | LMKKKGFPES | YDMHRLVKFV | SDLKSGVPNV | TAPVYSHLIY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DVIPDGDKTV | VQPDILILEG | LNVLQSGMDY | PHDPHHVFVS | DFVDFSIYVD | APEDLLQTWY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| INRFLKFREG | AFTDPDSYFH | NYAKLTKEEA | IKTAMTLWKE | INWLNLKQNI | LPTRERASLI |
| 310 | |||||
| LTKSANHAVE | EVRLRK |