AiPD: Autoinhibited Protein Database

Gene name	atpC (papG, uncC, b3731, JW3709)
Protein name	ATP synthase epsilon chain
Names	ATP synthase F1 sector epsilon subunit, F-ATPase epsilon subunit
Species	Escherichia coli (strain K12)
KEGG Pathway	eco:b3731
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

66-139 (Predicted disordered autoinhibitory region) PR

66-139 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1AQT	X-ray	230 A	A	4-139	PDB
1BSH	NMR	-	A	2-139	PDB
1BSN	NMR	-	A	2-139	PDB
1FS0	X-ray	210 A	E	2-139	PDB
1QO1	X-ray	390 A	J	4-139	PDB
3OAA	X-ray	326 A	H/P/X/f	2-139	PDB
5T4O	EM	690 A	H	1-139	PDB
5T4P	EM	777 A	H	1-139	PDB
5T4Q	EM	853 A	H	1-139	PDB
6OQR	EM	310 A	H	1-139	PDB
6OQS	EM	330 A	H	1-139	PDB
6OQT	EM	310 A	H	1-139	PDB
6OQU	EM	320 A	H	1-139	PDB
6OQV	EM	330 A	H	1-139	PDB
6OQW	EM	310 A	H	1-139	PDB
6PQV	EM	330 A	H	1-139	PDB
6WNQ	EM	340 A	H	1-139	PDB
6WNR	EM	330 A	H	1-139	PDB
8DBS	EM	350 A	H	4-104	PDB
AF-P0A6E6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P0A6E6

Type	Name	Position	InterPro Accession
domain	ATP synthase, F1 complex, delta/epsilon subunit, N-terminal	6 - 84	IPR020546
domain	ATP synthase epsilon subunit, C-terminal domain	89 - 133	IPR020547

		Description
EC Number
Subcellular Localization	Cell inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
proton-transporting ATP synthase complex	A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.
proton-transporting ATP synthase complex, catalytic core F(1)	The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proton-transporting ATP synthase activity, rotational mechanism	Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out).

Name	Definition
proton motive force-driven ATP synthesis	The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.
proton motive force-driven plasma membrane ATP synthesis	The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins