P0A2E3

PR
Gene name
rpoD
Protein name
RNA polymerase sigma factor RpoD
Names
Sigma-70
Species
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG Pathway
stm:STM3211
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

26-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P0A2E3

Entry ID Method Resolution Chain Position Source
AF-P0A2E3-F1 Predicted AlphaFoldDB

No variants for P0A2E3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P0A2E3

No associated diseases with P0A2E3

12 regional properties for P0A2E3

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 405 - 418 IPR000943-1
domain RNA polymerase sigma-70 429 - 437 IPR000943-2
domain RNA polymerase sigma-70 553 - 565 IPR000943-3
domain RNA polymerase sigma-70 574 - 600 IPR000943-4
domain RNA polymerase sigma factor 70, region 1.1 4 - 81 IPR007127
domain RNA polymerase sigma-70 region 3 460 - 535 IPR007624
domain RNA polymerase sigma-70 region 2 381 - 450 IPR007627
domain RNA polymerase sigma-70 region 4 549 - 602 IPR007630
domain RNA polymerase sigma factor 70, non-essential domain 139 - 350 IPR007631
domain RNA polymerase sigma-70 region 1.2 98 - 128 IPR009042
domain RNA polymerase sigma factor RpoD, C-terminal 377 - 613 IPR012760
domain RNA polymerase sigma-70 like domain 377 - 602 IPR014284

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

1 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEQNPQSQLK LLVTRGKEQG YLTYAEVNDH LPEDIVDSDQ IEDIIQMIND MGIQVMEEAP
70 80 90 100 110 120
DADDLLLAEN TTSTDEDAEE AAAQVLSSVE SEIGRTTDPV RMYMREMGTV ELLTREGEID
130 140 150 160 170 180
IAKRIEDGIN QVQCSVAEYP EAITYLLEQY DRVEAEEARL SDLITGFVDP NAEEEMAPTA
190 200 210 220 230 240
THVGSELSQE DLDDDEDEDE EDGDDDAADD DNSIDPELAR EKFAELRAQY VVTRDTIKAK
250 260 270 280 290 300
GRSHAAAQEE ILKLSEVFKQ FRLVPKQFDY LVNSMRVMMD RVRTQERLIM KLCVEQCKMP
310 320 330 340 350 360
KKNFITLFTG NETSETWFNA AIAMNKPWSE KLHDVAEEVQ RCLQKLRQIE EETGLTIEQV
370 380 390 400 410 420
KDINRRMSIG EAKARRAKKE MVEANLRLVI SIAKKYTNRG LQFLDLIQEG NIGLMKAVDK
430 440 450 460 470 480
FEYRRGYKFS TYATWWIRQA ITRSIADQAR TIRIPVHMIE TINKLNRISR QMLQEMGREP
490 500 510 520 530 540
TPEELAERML MPEDKIRKVL KIAKEPISME TPIGDDEDSH LGDFIEDTTL ELPLDSATTE
550 560 570 580 590 600
SLRAATHDVL AGLTAREAKV LRMRFGIDMN TDHTLEEVGK QFDVTRERIR QIEAKALRKL
610
RHPSRSEVLR SFLDD