P0A142
Gene name |
pahE |
Protein name |
Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase |
Names |
THBPA hydratase-aldolase, 2'-hydroxybenzalpyruvate aldolase |
Species |
Pseudomonas aeruginosa |
KEGG Pathway |
|
EC number |
4.1.2.45: Aldehyde-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P0A142
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P0A142-F1 | Predicted | AlphaFoldDB |
No variants for P0A142
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P0A142 | |||||
No associated diseases with P0A142
No regional properties for P0A142
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P0A142 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.2.45 | Aldehyde-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity | Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| aromatic compound catabolic process | The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNKIMKTSR | LTAEDINGAW | TIMPTPSTPD | ASDWRSTATV | DLEETARIVE | ELIAAGVNGI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSMGTFGECA | TLTWDEKRDY | VSTIVETIRG | RVPYFCGTTA | LNTREVIRQT | RELIDIGANG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TMLGVPMWVK | MDLPTAVQFY | RDVADAVPEA | AIAIYANPEA | FKFDFPRPFW | AEMSKIPQVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TAKYLGIGML | DLDLRLAPNI | RFLPHEDDYY | AAARINPERI | TAFWSSGAMC | GPATAIMLRD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EVVRAKSTGD | WAKAKAISDD | MRAADSTLFP | RGDFSEFSKY | NIGLEKARMD | AAGWLKAGPC |
| 310 | 320 | 330 | |||
| RPPYNLVPED | YLAGAQKSGK | AWAALHAKYS | NELK |