AiPD: Autoinhibited Protein Database

Gene name	gyrB
Protein name	DNA gyrase subunit B
Names
Species	Staphylococcus aureus
KEGG Pathway
EC number	5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-49 (Predicted disordered autoinhibitory region) PR

1-49 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3G75	X-ray	230 A	A/B	24-230	PDB
3G7B	X-ray	230 A	A/B	24-230	PDB
3TTZ	X-ray	163 A	A/B	14-233	PDB
3U2D	X-ray	185 A	A/B	14-233	PDB
3U2K	X-ray	164 A	A/B	14-233	PDB
4PLB	X-ray	269 A			PDB
4URM	X-ray	294 A	A/B/C/D	1-231	PDB
4URO	X-ray	259 A	A/B/C/D	1-231	PDB
5BS3	X-ray	265 A			PDB
5CPH	X-ray	120 A	A/B	2-234	PDB
5CTU	X-ray	145 A	A/B	2-234	PDB
5CTW	X-ray	148 A	A/B	2-234	PDB
5CTX	X-ray	160 A	A/B	2-234	PDB
5CTY	X-ray	160 A	A/B	2-234	PDB
5D6P	X-ray	205 A	A/B	2-234	PDB
5D6Q	X-ray	150 A	A/B	2-234	PDB
5D7C	X-ray	155 A	A/B	2-234	PDB
5D7D	X-ray	160 A	A/B	2-234	PDB
5D7R	X-ray	155 A	A/B	2-234	PDB
5IWI	X-ray	198 A			PDB
5IWM	X-ray	250 A			PDB
5Z9P	X-ray	145 A	A/B	14-233	PDB
6QTK	X-ray	231 A	B/D	409-644	PDB
6QTP	X-ray	237 A			PDB
6QX1	X-ray	265 A	B/D	409-543	PDB
6QX2	X-ray	340 A	B/S/b/s	416-638	PDB
6TCK	X-ray	160 A	A/B	2-234	PDB
6TTG	X-ray	170 A	A/B	2-234	PDB
6Z1A	X-ray	230 A	B/D	409-644	PDB
7MVS	X-ray	260 A			PDB
AF-P0A0K8-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P0A0K8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P0A0K8

		Description
EC Number	5.6.2.2	Enzymes altering nucleic acid conformation
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding	Binding to a metal ion.

Name	Definition
DNA topological change	The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication	A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
response to antibiotic	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins