P09880

PR
Gene name
TRL1 (RLG1, YJL087C, J0927)
Protein name
tRNA ligase
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJL087C
EC number
6.5.1.3: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P09880

Entry ID Method Resolution Chain Position Source
AF-P09880-F1 Predicted AlphaFoldDB

17 variants for P09880

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-272228 85 D>N No SGRP
s10-272186 99 N>D No SGRP
s10-272096 129 T>S No SGRP
s10-271798 228 A>V No SGRP
s10-271787 232 G>R No SGRP
s10-271472 337 K>E No SGRP
s10-271430 351 L>M No SGRP
s10-271068 471 N>K No SGRP
s10-270972 503 I>M No SGRP
s10-270844 546 K>I No SGRP
s10-270795 562 Q>H No SGRP
s10-270700 594 I>T No SGRP
s10-270521 654 E>Q No SGRP
s10-270479 668 V>I No SGRP
s10-270195 762 N>K No SGRP
s10-270101 794 V>I No SGRP
s10-270050 811 V>L No SGRP

No associated diseases with P09880

No regional properties for P09880

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P09880

Functions

Description
EC Number 6.5.1.3 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.

5 GO annotations of molecular function

Name Definition
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA.
RNA ligase (ATP) activity Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m).

5 GO annotations of biological process

Name Definition
IRE1-mediated unfolded protein response The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of translation in response to stress Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress.
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay.
tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSPYDGKRT VTQLVNELEK AEKLSGRGRA YRRVCDLSHS NKKVISWKFN EWDYGKNTIT
70 80 90 100 110 120
LPCNARGLFI SDDTTNPVIV ARGYDKFFNV GEVNFTKWNW IEENCTGPYD VTIKANGCII
130 140 150 160 170 180
FISGLEDGTL VVCSKHSTGP RADVDRNHAE AGEKQLLRQL AAMNINRSDF ARMLYTHNVT
190 200 210 220 230 240
AVAEYCDDSF EEHILEYPLE KAGLYLHGVN VNKAEFETWD MKDVSQMASK YGFRCVQCIT
250 260 270 280 290 300
SNTLEDLKKF LDNCSATGSF EGQEIEGFVI RCHLKSTEKP FFFKYKFEEP YLMYRQWREV
310 320 330 340 350 360
TKDYISNKSR VFKFRKHKFI TNKYLDFAIP ILESSPKICE NYLKGFGVIE LRNKFLQSYG
370 380 390 400 410 420
MSGLEILNHE KVAELELKNA IDYDKVDERT KFLIFPISVI GCGKTTTSQT LVNLFPDSWG
430 440 450 460 470 480
HIQNDDITGK DKSQLMKKSL ELLSKKEIKC VIVDRNNHQF RERKQLFEWL NELKEDYLVY
490 500 510 520 530 540
DTNIKVIGVS FAPYDKLSEI RDITLQRVIK RGNNHQSIKW DELGEKKVVG IMNGFLKRYQ
550 560 570 580 590 600
PVNLDKSPDN MFDLMIELDF GQADSSLTNA KQILNEIHKA YPILVPEIPK DDEIETAFRR
610 620 630 640 650 660
SLDYKPTVRK IVGKGNNNQQ KTPKLIKPTY ISAKIENYDE IIELVKRCIA SDAELTEKFK
670 680 690 700 710 720
HLLASGKVQK ELHITLGHVM SSREKEAKKL WKSYCNRYTD QITEYNNNRI ENAQGSGNNQ
730 740 750 760 770 780
NTQVKTTDKL NFRLEKLCWD EKIIAIVVEL SKDKDGCIID ENNEKIKGLC CQNKIPHITL
790 800 810 820
CKLESGVKAV YSNVLCEKVE SAEVDENIKV VKLDNSKEFV GSVYLNF