P09846

PR
Gene name
rpo1N
Protein name
DNA-directed RNA polymerase subunit Rpo1N
Names
DNA-directed RNA polymerase subunit A'
Species
Methanothermobacter thermautotrophicus (strain Winter) (Methanobacterium thermoautotrophicum)
KEGG Pathway
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

118-351 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P09846

Entry ID Method Resolution Chain Position Source
AF-P09846-F1 Predicted AlphaFoldDB

No variants for P09846

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P09846

No associated diseases with P09846

6 regional properties for P09846

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 311 - 477 IPR000722
domain RNA polymerase, N-terminal 201 - 496 IPR006592
domain RNA polymerase Rpb1, domain 3 524 - 637 IPR007066
domain RNA polymerase Rpb1, domain 1 6 - 309 IPR007080
domain RNA polymerase Rpb1, domain 5 783 - 838 IPR007081
domain RNA polymerase Rpb1, domain 4 663 - 770 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRGILKKISQ INFGLMSPED IRKMSVAQIV TPDTYDEDGY PIENELMDPR LGVIGSSLRC
70 80 90 100 110 120
RSCGAKGGEC PGHFGSINLA RPVIHVGFAD TIHKILSSIC RKCSRILLTE TEIQDYRQRI
130 140 150 160 170 180
LEAMEREESL TPIIKEIYAE ARRDRCPHCE EEQEEIKLDK PVSIVEGDYK LTPSEVRERL
190 200 210 220 230 240
ERITDNDSLL LGVNPEVARP EWMVLTVLPV PPVTVRPSIT LETGERSEDD LTHKLVDILR
250 260 270 280 290 300
INQRLKENME AGAPQLIVED LWELLQYHVT TYFDNEASGV PPARHRSGRP LKTLAQRLKG
310 320 330 340 350 360
KEGRFRSNLS GKRVNFSART VVSPDPNVSV NEVGVPELIA KEVTVPVYVT EWNIDRMKEH
370 380 390 400 410 420
IENGPDVHPG ANYVIRPDGR KIRAYNETKD VVLENLKPGY IVERHLKDGD IVLFNRQPSL
430 440 450 460 470 480
HRMSMMAHEV RVLPYKTFRL NLCVCPPYNA DFDGDEMNMH VFQTEESRAE AKTLMRVQDH
490 500 510 520 530 540
ILSPRFRDLS SGVYTTISQE HTSSQGKRLF SVRSRPPDPQ EGRAPPPDRE GREWTVKEIF
550 560 570 580 590 600
SMVLPDDLNM VYLAEICRKC DECLEMDWEN DAYVVIENGQ LITGVIDEKA YGAFAGKILD
610 620 630 640 650 660
QIVKEYGSDA AKEFLDSATK LAIAGIMHAG FTTSTNDEEI PEEAKERIEA HLRNAEARVD
670 680 690 700 710 720
QLIEAYENGE LEPLPGRSLE ETLEMKIMQV LGEAKDKSGE IAESYFDMDE NHAVIMALTG
730 740 750 760 770 780
ARGAMLNLTQ ITACVGQQSV HGGRITRGYD NRTLPHFKKG ELGAKSRGFV HSSYKEDSIL
790 800 810 820 830 840
LEFMGGREGL VDTAIRTAQS GYMQRRLVNA LQDLTVDENG RVVDNRGVII QTRFGEDGVD
850 860
PAKSDYGKIV DLDKLVQEIR LKSGK