AiPD: Autoinhibited Protein Database

Gene name	pma1 (SPAC1071.10c)
Protein name	Plasma membrane ATPase 1
Names	Proton pump 1
Species	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway	spo:SPAC1071.10c
EC number	7.1.2.1: Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-102 (Predicted disordered autoinhibitory region) PR

1-102 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P09627-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
I_3874636_G_T	15	A>D	No	Jeffares_SNPs
I_3874539_C_A	47	E>D	No	Jeffares_SNPs
I_3874530_G_T	50	F>L	No	Jeffares_SNPs
I_3874436_T_G	82	M>L	No	Jeffares_SNPs
I_3874435_A_G	82	M>T	No	Jeffares_SNPs
I_3874040_C_T	214	V>I	No	Jeffares_SNPs
I_3874033_G_C	216	T>S	No	Jeffares_SNPs
I_3873779_G_A	301	L>F	No	Jeffares_SNPs
I_3873623_C_T	353	E>K	No	Jeffares_SNPs
I_3873532_T_C	383	K>R	No	Jeffares_SNPs
I_3873356_T_C	442	K>E	No	Jeffares_SNPs
I_3873136_C_T	515	R>H	No	Jeffares_SNPs
I_3872947_T_C	578	N>S	No	Jeffares_SNPs
I_3872522_C_T	720	V>I	No	Jeffares_SNPs
I_3872180_T_C	834	I>V	No	Jeffares_SNPs
I_3872166_C_G	838	M>I	No	Jeffares_SNPs
I_3872054_T_C	876	I>V	No	Jeffares_SNPs
I_3871994_T_C	896	N>D	No	Jeffares_SNPs
I_3871985_A_T	899	S>T	No	Jeffares_SNPs
I_3871930_C_T	917	G>D	No	Jeffares_SNPs

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	17 - 269	IPR000719
active_site	Serine/threonine-protein kinase, active site	136 - 148	IPR008271

		Description
EC Number	7.1.2.1	Hydron translocation linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
metal ion binding	Binding to a metal ion.
P-type ion transporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.
P-type proton-exporting transporter activity	Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.
proton binding	Binding to proton.

Name	Definition
ion transmembrane transport	A process in which an ion is transported across a membrane.
proton export across plasma membrane	The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region.
proton transmembrane transport	The directed movement of a proton across a membrane.
regulation of intracellular pH	Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins