P09601
PR
Gene name |
HMOX1 (HO, HO1) |
Protein name |
Heme oxygenase 1 |
Names |
HO-1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:3162 |
EC number |
1.14.14.18: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
27 structures for P09601
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1N3U | X-ray | 258 A | A/B | 1-233 | PDB |
| 1N45 | X-ray | 150 A | A/B | 1-233 | PDB |
| 1NI6 | X-ray | 210 A | A/B/C/D | 1-224 | PDB |
| 1OYK | X-ray | 259 A | A/B | 1-233 | PDB |
| 1OYL | X-ray | 159 A | A/B | 1-233 | PDB |
| 1OZE | X-ray | 219 A | A/B | 1-233 | PDB |
| 1OZL | X-ray | 158 A | A/B | 1-233 | PDB |
| 1OZR | X-ray | 174 A | A/B | 1-233 | PDB |
| 1OZW | X-ray | 155 A | A/B | 1-233 | PDB |
| 1S13 | X-ray | 229 A | A/B | 1-233 | PDB |
| 1S8C | X-ray | 219 A | A/B/C/D | 1-233 | PDB |
| 1T5P | X-ray | 211 A | A/B | 1-233 | PDB |
| 1TWN | X-ray | 220 A | A/B | 1-233 | PDB |
| 1TWR | X-ray | 210 A | A/B | 1-233 | PDB |
| 1XJZ | X-ray | 188 A | A/B | 1-233 | PDB |
| 1XK0 | X-ray | 218 A | A/B | 1-233 | PDB |
| 1XK1 | X-ray | 208 A | A/B | 1-233 | PDB |
| 1XK2 | X-ray | 220 A | A/B | 1-233 | PDB |
| 1XK3 | X-ray | 208 A | A/B | 1-233 | PDB |
| 3CZY | X-ray | 154 A | A/B | 1-233 | PDB |
| 3HOK | X-ray | 219 A | A/B | 1-233 | PDB |
| 3K4F | X-ray | 217 A | A/B | 1-233 | PDB |
| 3TGM | X-ray | 285 A | A/B | 1-233 | PDB |
| 4WD4 | X-ray | 295 A | A/B/C/D | 1-288 | PDB |
| 5BTQ | X-ray | 208 A | A/B | 1-233 | PDB |
| 6EHA | X-ray | 200 A | A/B | 1-288 | PDB |
| AF-P09601-F1 | Predicted | AlphaFoldDB |
287 variants for P09601
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1391750606 CA411351042 |
2 | E>A | No |
ClinGen gnomAD |
|
|
CA323517558 rs932354596 |
3 | R>G | No |
ClinGen gnomAD |
|
|
rs1334211225 CA411351057 |
3 | R>H | No |
ClinGen gnomAD |
|
|
rs1238534765 CA411351068 |
4 | P>L | No |
ClinGen gnomAD |
|
|
rs1238534765 CA411351067 |
4 | P>R | No |
ClinGen gnomAD |
|
|
rs1350094270 CA411351097 |
6 | P>L | No |
ClinGen gnomAD |
|
|
CA411351092 rs1256686888 |
6 | P>S | No |
ClinGen gnomAD |
|
|
rs1483623337 CA411351111 CA411351113 |
7 | D>E | No |
ClinGen gnomAD |
|
|
CA10204586 VAR_019165 rs2071747 |
7 | D>H | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1438904518 CA411351309 |
8 | S>R | No |
ClinGen gnomAD |
|
|
CA10204605 CA411351311 rs768435104 |
9 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204606 rs551161442 |
10 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs551161442 CA411351318 |
10 | P>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1428247265 CA411351343 |
13 | L>F | No |
ClinGen TOPMed |
|
|
rs369762159 CA10204608 |
13 | L>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA411351362 rs1298040151 |
16 | A>S | No |
ClinGen TOPMed |
|
|
rs199554283 CA10204609 |
17 | L>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA323518928 rs150399064 |
18 | K>M | No |
ClinGen ESP TOPMed |
|
|
rs1601739478 RCV000997913 |
19 | E>missing | No |
ClinVar dbSNP |
|
|
CA411351394 rs1413931872 |
19 | E>D | No |
ClinGen TOPMed |
|
|
CA10204613 rs759034514 |
20 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs765713465 CA10204612 |
20 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765713465 CA10204611 |
20 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA411351425 rs1474577861 |
22 | K>T | No |
ClinGen TOPMed |
|
|
CA411351446 rs1262185822 |
23 | E>D | No |
ClinGen TOPMed |
|
|
rs1601739499 CA411351480 |
26 | T>I | No |
ClinGen Ensembl |
|
|
CA10204614 rs764534101 |
28 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA10204615 rs77672261 |
29 | E>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10204616 rs757462491 |
32 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1188261720 CA411351577 |
33 | F>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1427779590 CA411351588 |
34 | M>I | No |
ClinGen gnomAD |
|
|
CA323518953 rs903490384 |
34 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA10204618 rs745903133 |
41 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA411351691 rs1460096543 |
41 | Q>R | No |
ClinGen gnomAD |
|
|
CA411351717 rs1274546571 |
43 | T>I | No |
ClinGen TOPMed |
|
|
CA10204619 rs756151512 |
44 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204620 rs149118304 |
44 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10204623 rs768627741 |
45 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204621 rs749208024 |
45 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA10204624 rs747965867 |
46 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204625 rs367932474 |
47 | F>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA gnomAD |
|
CA10204626 rs772748655 |
48 | K>R | No |
ClinGen ExAC TOPMed |
|
|
CA411352114 rs1601741349 |
50 | V>G | No |
ClinGen Ensembl |
|
|
CA411352109 rs1176147476 |
50 | V>L | No |
ClinGen gnomAD |
|
|
CA10204647 rs759140880 |
51 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs1374172290 CA411352117 |
51 | M>L | No |
ClinGen gnomAD |
|
|
CA323521453 rs1055459409 |
51 | M>T | No |
ClinGen Ensembl |
|
|
rs963351011 CA323521458 |
52 | A>V | No |
ClinGen TOPMed |
|
|
CA411352143 rs1356598938 |
55 | Y>C | No |
ClinGen gnomAD |
|
|
rs565887386 CA10204648 |
56 | H>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA323521466 rs762448489 |
58 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs775004553 CA10204649 |
58 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1184993008 CA411352162 |
58 | Y>D | No |
ClinGen TOPMed |
|
|
CA10204651 rs767759739 |
59 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs1304906003 CA411352176 |
60 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1304906003 CA411352178 |
60 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1199760869 CA411352189 COSM281733 |
62 | E>D | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
CA10204652 rs750846312 |
62 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA411352193 rs1262409403 |
63 | E>* | No |
ClinGen TOPMed |
|
|
rs1601741392 CA411352199 |
64 | E>K | No |
ClinGen Ensembl |
|
|
CA10204653 rs377208959 |
65 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10204654 rs766615761 |
67 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs753863879 CA10204655 |
67 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA10204656 rs200856037 |
68 | N>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA411352236 rs1292741154 |
69 | K>R | No |
ClinGen TOPMed |
|
|
rs778752673 CA10204657 |
70 | E>G | No |
ClinGen ExAC gnomAD |
|
|
rs113683735 CA323521496 |
71 | S>G | No |
ClinGen Ensembl |
|
|
CA10204659 rs758414026 |
74 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA411352274 rs138680581 |
75 | A>S | No |
ClinGen ESP ExAC TOPMed |
|
|
CA10204661 rs138680581 |
75 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed |
|
rs574454960 CA10204662 |
75 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1032960920 CA323521513 COSM1033739 |
76 | P>H | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
CA411352279 rs1447344275 |
76 | P>S | No |
ClinGen gnomAD |
|
|
rs369019087 CA10204664 |
78 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs369019087 CA411352292 |
78 | Y>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA411352289 rs1463003938 |
78 | Y>H | No |
ClinGen TOPMed |
|
|
rs536618397 CA411352302 |
79 | F>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 81 | E>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775196835 CA10204666 |
82 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 82 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10204668 rs772672081 |
83 | L>V | No |
ClinGen ExAC gnomAD |
|
|
COSM1209826 CA10204669 rs141730669 |
85 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA10204670 rs141730669 |
85 | R>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs766527808 CA10204671 |
85 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
RCV001321298 rs766527808 |
85 | R>L | No |
ClinVar dbSNP |
|
|
TCGA novel rs759817600 CA10204673 |
86 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen ExAC gnomAD |
|
CA10204672 rs754059391 |
86 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs1601741492 CA411352347 |
87 | A>P | No |
ClinGen Ensembl |
|
|
rs765282681 CA10204674 |
87 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA10204676 rs146227657 |
88 | A>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA411352351 rs1242375329 |
88 | A>P | No |
ClinGen TOPMed |
|
|
rs942857305 CA323521606 |
90 | E>G | No |
ClinGen TOPMed |
|
|
CA411352362 rs1257822129 |
90 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs921986454 CA323521608 COSM1415991 |
92 | D>G | large_intestine [Cosmic] | No |
ClinGen cosmic curated Ensembl |
| TCGA novel | 92 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs751257756 CA10204678 |
93 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA10204679 rs757122732 |
94 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA323521615 rs757122732 |
94 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA411352393 rs1244331514 |
95 | F>Y | No |
ClinGen gnomAD |
|
|
CA10204681 rs137932222 |
96 | W>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs755879599 CA10204682 |
96 | W>C | No |
ClinGen ExAC gnomAD |
|
|
rs748860646 CA10204684 |
98 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 99 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs772407562 CA10204685 |
99 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773781083 CA10204686 |
100 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204687 rs747303322 |
100 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1297001551 CA411352444 |
103 | E>K | No |
ClinGen TOPMed |
|
|
CA10204689 rs141643776 |
105 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA323521681 VAR_022156 rs9282702 |
106 | P>L | No |
ClinGen UniProt Ensembl dbSNP |
|
|
rs765477403 CA10204691 |
107 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA323521694 rs902896454 |
107 | Y>H | No |
ClinGen TOPMed |
|
|
rs376132596 CA323521699 |
108 | T>A | No |
ClinGen ESP TOPMed |
|
|
CA10204692 rs775386710 |
109 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA10204693 rs763108705 |
110 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA10204694 rs763872699 |
110 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757322587 CA10204696 |
111 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA411352493 rs1193526478 |
111 | M>T | No |
ClinGen gnomAD |
|
|
rs572321710 CA10204697 |
113 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs11555830 CA10204699 |
113 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs572321710 CA10204698 |
113 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs779778162 CA10204700 |
115 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204702 rs373670270 |
117 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10204701 rs748685977 |
117 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA411352544 rs541298817 |
119 | H>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10204705 rs113166818 |
120 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204704 rs747498006 |
120 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA411352556 rs1601741654 |
121 | V>G | No |
ClinGen Ensembl |
|
|
CA411352566 rs1239968647 COSM1033742 |
123 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs903006597 CA323521791 |
123 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA411352573 rs1304968056 |
124 | T>I | No |
ClinGen TOPMed |
|
|
rs200456582 CA10204708 |
124 | T>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10204710 rs763151157 |
125 | E>D | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA10204709 rs775787073 |
125 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774342824 COSM392953 CA10204712 |
127 | E>K | lung [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs774342824 CA411352586 |
127 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA411352604 rs1182041236 |
130 | V>L | No |
ClinGen gnomAD |
|
|
CA411352613 rs373577583 |
131 | A>G | No |
ClinGen ESP ExAC gnomAD |
|
|
rs373577583 CA10204713 |
131 | A>V | No |
ClinGen ESP ExAC gnomAD |
|
|
CA10204715 rs750192990 |
133 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA411352636 rs760556663 |
135 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA10204716 rs760556663 |
135 | T>S | No |
ClinGen ExAC gnomAD |
|
|
rs765877829 CA10204717 |
135 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA411352641 rs1300886472 |
136 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs201596112 CA10204718 |
136 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778459375 CA10204720 |
138 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs374687228 CA10204721 |
139 | G>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA411352667 rs746165512 |
140 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781675840 CA411352665 |
140 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781675840 CA10204723 |
140 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1350704581 CA411352680 |
143 | G>R | No |
ClinGen gnomAD |
|
|
rs368454530 CA10204726 |
144 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1481150465 CA411352693 |
145 | Q>P | No |
ClinGen gnomAD |
|
|
CA411352701 rs1601741743 |
146 | V>G | No |
ClinGen Ensembl |
|
|
CA411352710 rs1275901787 COSM3708231 |
148 | K>E | liver [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
rs1456122355 CA411352720 |
149 | K>E | No |
ClinGen gnomAD |
|
|
CA411352724 rs1228175888 |
149 | K>N | No |
ClinGen TOPMed |
|
|
rs1456122355 CA411352718 |
149 | K>Q | No |
ClinGen gnomAD |
|
|
COSM272780 CA10204728 rs768800478 RCV001325924 |
151 | A>V | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ClinVar ExAC NCI-TCGA dbSNP gnomAD |
|
rs5755713 CA323521926 |
152 | Q>H | No |
ClinGen Ensembl |
|
|
rs200966095 CA10204730 |
153 | K>I | No |
ClinGen 1000Genomes ExAC |
|
|
rs200255845 CA10204731 |
153 | K>N | No |
ClinGen 1000Genomes ExAC |
|
|
rs202031269 CA10204729 |
153 | K>Q | No |
ClinGen 1000Genomes ExAC |
|
|
CA411352767 rs1395110739 |
156 | D>E | No |
ClinGen gnomAD |
|
|
CA323521944 rs867240308 |
160 | S>P | No |
ClinGen Ensembl |
|
|
rs760594009 CA10204733 |
162 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760594009 CA411352799 |
162 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204734 rs200053095 |
163 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA323521960 rs996149451 |
164 | L>V | No |
ClinGen Ensembl |
|
|
CA10204735 rs753622181 |
166 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs759192105 CA10204736 |
166 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs764824843 CA10204737 |
167 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1446252924 CA411352833 |
167 | F>S | No |
ClinGen TOPMed gnomAD |
|
|
rs752149044 CA10204738 |
171 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA411352889 rs1308512619 |
171 | N>K | No |
ClinGen gnomAD |
|
|
CA10204739 rs757909193 |
171 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs552652411 CA10204740 |
172 | I>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA411352902 rs1256495165 |
172 | I>T | No |
ClinGen gnomAD |
|
|
rs552652411 CA411352896 |
172 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA323522023 rs1029004837 |
174 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1319579083 CA411352952 |
177 | K>E | No |
ClinGen TOPMed |
|
|
rs750919042 CA411352964 |
177 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA411352970 rs1569056302 |
178 | F>L | No |
ClinGen Ensembl |
|
|
rs778761905 CA323522026 |
180 | Q>E | No |
ClinGen Ensembl |
|
|
CA10204742 rs756629722 |
180 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
CA10204743 rs780433638 |
181 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs749644285 CA10204745 |
183 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204744 rs749644285 |
183 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748169225 CA10204747 |
185 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204748 rs748169225 |
185 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA323522058 rs867650379 |
185 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA411353057 rs867650379 |
185 | R>L | No |
ClinGen gnomAD |
|
|
rs947623654 CA323522071 |
186 | M>V | No |
ClinGen TOPMed |
|
|
CA411353090 rs1465332069 |
188 | S>P | No |
ClinGen gnomAD |
|
|
CA10204750 rs760635812 |
191 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204751 rs367760328 |
192 | T>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs148949789 CA10204752 |
193 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs775119762 COSM2149494 CA10204755 |
194 | A>T | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA10204756 rs762652176 |
194 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA411353306 rs1298165167 |
199 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
CA10204759 rs548430137 |
200 | I>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10204758 rs751072024 |
200 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204764 rs138349040 |
206 | A>E | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10204762 rs199535572 |
206 | A>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
COSM1033743 rs138349040 CA10204763 |
206 | A>V | endometrium [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
| TCGA novel | 209 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA411353473 rs1403756497 |
211 | I>T | No |
ClinGen gnomAD |
|
|
COSM1662161 rs202094347 CA323522187 |
212 | Q>H | kidney [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA411353583 rs1373507590 |
213 | L>V | No |
ClinGen gnomAD |
|
|
rs1601744030 CA411353617 |
215 | E>D | No |
ClinGen Ensembl |
|
|
rs1241685742 CA411353624 |
216 | E>* | No |
ClinGen gnomAD |
|
|
CA411353653 rs1352922801 |
218 | Q>E | No |
ClinGen gnomAD |
|
|
rs745771727 CA10204789 |
218 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs199705355 CA411353707 |
223 | H>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10204792 rs749101755 |
223 | H>P | No |
ClinGen ExAC gnomAD |
|
|
rs199705355 CA10204791 |
223 | H>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA411353747 rs1233662522 |
225 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA411353745 rs1233662522 |
225 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
rs566190009 CA10204793 |
226 | K>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA411353768 rs1455111177 |
227 | D>A | No |
ClinGen gnomAD |
|
|
CA10204794 rs140364055 |
227 | D>N | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1601744053 CA411353809 |
230 | P>H | No |
ClinGen Ensembl |
|
| TCGA novel | 232 | R>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA411353822 rs527424080 |
232 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA411353825 rs1414251328 |
232 | R>L | No |
ClinGen gnomAD |
|
|
CA411353828 rs1414251328 |
232 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA10204795 RCV001306486 rs527424080 |
232 | R>W | No |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA411353831 rs771466012 |
233 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204796 rs771466012 |
233 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA411353836 rs1448467554 |
233 | A>V | No |
ClinGen gnomAD |
|
|
CA323525641 rs937789743 |
234 | P>L | No |
ClinGen TOPMed |
|
|
rs1375477038 CA411353855 |
235 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1005700341 CA323525650 |
235 | G>R | No |
ClinGen Ensembl |
|
|
CA411353864 rs1375477038 |
235 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
rs145427664 CA10204799 |
237 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs145427664 RCV001350633 CA10204798 |
237 | R>G | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA10204800 rs183007438 |
237 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA411353891 rs1273376177 |
238 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1273376177 CA411353889 |
238 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
CA10204804 RCV001320950 rs201083816 |
239 | R>Q | Variant assessed as Somatic; 4.786e-05 impact. [NCI-TCGA] | No |
ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD |
|
CA10204803 rs374813554 |
239 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1468950550 CA411353908 |
240 | A>T | No |
ClinGen gnomAD |
|
|
CA411353916 rs1245484293 |
241 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1477953350 CA411353919 |
241 | S>T | No |
ClinGen TOPMed gnomAD |
|
|
CA10204806 rs750535199 |
242 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA411353927 rs1261195153 |
242 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1426176726 CA411353937 |
244 | V>M | No |
ClinGen gnomAD |
|
|
rs757750519 CA323525723 |
245 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs529551358 CA10204807 |
246 | D>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs780175193 CA10204828 |
247 | S>A | No |
ClinGen ExAC gnomAD |
|
|
CA10204829 rs200939820 |
247 | S>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs778536840 CA10204831 |
248 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA10204832 rs748004359 |
248 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777575961 CA10204834 |
250 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA411354092 rs777575961 |
250 | V>M | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 250 | V>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1465655693 CA411354120 |
252 | T>I | No |
ClinGen TOPMed |
|
|
rs1601745725 CA411354112 |
252 | T>P | No |
ClinGen Ensembl |
|
|
rs772562670 CA323528575 |
253 | P>L | No |
ClinGen Ensembl |
|
|
CA411354128 rs1424064519 |
253 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
COSM1751847 CA411354144 rs1214295740 |
254 | R>T | urinary_tract [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
rs770555326 CA10204836 |
255 | G>W | No |
ClinGen ExAC gnomAD |
|
|
CA411354220 rs769237502 |
260 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749782022 CA10204838 |
260 | N>T | No |
ClinGen ExAC gnomAD |
|
|
rs774532106 CA10204840 |
261 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs149487862 RCV001348789 CA10204841 |
262 | R>C | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA411354242 rs1297383655 |
262 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA411354268 rs1569059349 |
265 | A>S | No |
ClinGen Ensembl |
|
|
CA10204843 rs35980144 COSM132705 |
266 | P>L | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA411354291 rs1340015433 |
267 | L>H | No |
ClinGen gnomAD |
|
|
rs935874465 CA323528666 |
268 | L>P | No |
ClinGen Ensembl |
|
|
CA10204845 rs766420732 |
269 | R>* | No |
ClinGen ExAC gnomAD |
|
|
CA10204846 COSM1033744 rs143057716 |
269 | R>Q | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1240007740 CA411354337 |
271 | V>I | No |
ClinGen gnomAD |
|
|
rs754828801 CA10204847 |
273 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs1601745778 CA411354418 |
274 | L>F | No |
ClinGen Ensembl |
|
|
CA10204848 rs767420233 |
277 | L>F | No |
ClinGen ExAC |
|
|
CA10204849 rs148193694 |
279 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10204851 rs374133554 |
280 | T>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10204855 rs746642457 |
283 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10204853 rs944783473 |
283 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA411354675 rs1177836220 |
285 | L>F | No |
ClinGen gnomAD |
|
|
CA411354696 rs1467383876 |
286 | Y>* | No |
ClinGen gnomAD |
|
|
CA10204857 rs780810520 |
286 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs202209408 CA10204858 |
287 | A>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1601745813 CA411354700 |
287 | A>S | No |
ClinGen Ensembl |
|
|
rs1333482347 CA411354706 |
288 | M>T | No |
ClinGen gnomAD |
|
|
CA323528788 rs954025025 |
288 | M>V | No |
ClinGen TOPMed gnomAD |
1 associated diseases with P09601
[MIM: 614034]: Heme oxygenase 1 deficiency (HMOX1D)
A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. {ECO:0000269|PubMed:9884342}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. {ECO:0000269|PubMed:9884342}. Note=The disease is caused by variants affecting the gene represented in this entry.
1 regional properties for P09601
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Haem oxygenase conserved site | 129 - 139 | IPR018207 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.14.18 | With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| caveola | A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| heme oxygenase (decyclizing) activity | Catalysis of the reaction: heme b + 3 O2 + 3 reduced |
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
52 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cellular iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. |
| cellular response to arsenic-containing substance | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. |
| cellular response to cadmium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. |
| cellular response to cisplatin | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus. |
| cellular response to heat | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| cellular response to nutrient | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. |
| endothelial cell proliferation | The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. |
| epithelial cell apoptotic process | Any apoptotic process in an epithelial cell. |
| erythrocyte homeostasis | Any process of regulating the production and elimination of erythrocytes within an organism. |
| heme catabolic process | The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
| heme oxidation | The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| intrinsic apoptotic signaling pathway in response to DNA damage | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. |
| iron ion homeostasis | Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. |
| liver regeneration | The regrowth of lost or destroyed liver. |
| low-density lipoprotein particle clearance | The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. |
| macroautophagy | The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded. |
| negative regulation of DNA binding | Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). |
| negative regulation of DNA-binding transcription factor activity | Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| negative regulation of epithelial cell apoptotic process | Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process. |
| negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors. |
| negative regulation of leukocyte migration | Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration. |
| negative regulation of macroautophagy | Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. |
| negative regulation of mast cell cytokine production | Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production. |
| negative regulation of mast cell degranulation | Any process that stops, prevents, or reduces the rate of mast cell degranulation. |
| negative regulation of muscle cell apoptotic process | Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death. |
| negative regulation of neuron apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
| negative regulation of smooth muscle cell proliferation | Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation. |
| negative regulation of vascular associated smooth muscle cell proliferation | Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation. |
| positive regulation of angiogenesis | Any process that activates or increases angiogenesis. |
| positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell proliferation involved in sprouting angiogenesis. |
| positive regulation of cell migration involved in sprouting angiogenesis | Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. |
| positive regulation of chemokine production | Any process that activates or increases the frequency, rate, or extent of chemokine production. |
| positive regulation of epithelial cell apoptotic process | Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process. |
| positive regulation of I-kappaB kinase/NF-kappaB signaling | Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. |
| positive regulation of macroautophagy | Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. |
| positive regulation of smooth muscle cell proliferation | Any process that activates or increases the rate or extent of smooth muscle cell proliferation. |
| regulation of angiogenesis | Any process that modulates the frequency, rate or extent of angiogenesis. |
| regulation of blood pressure | Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. |
| regulation of DNA-binding transcription factor activity | Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| regulation of transcription from RNA polymerase II promoter in response to iron | Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus. |
| regulation of transcription from RNA polymerase II promoter in response to oxidative stress | Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| response to estrogen | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics. |
| response to hydrogen peroxide | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
| response to nicotine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. |
| response to oxidative stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| small GTPase mediated signal transduction | The series of molecular signals in which a small monomeric GTPase relays a signal. |
| smooth muscle hyperplasia | A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ. |
| wound healing involved in inflammatory response | The series of events that restore integrity to damaged tissue that contribute to an inflammatory response. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERPQPDSMP | QDLSEALKEA | TKEVHTQAEN | AEFMRNFQKG | QVTRDGFKLV | MASLYHIYVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEEEIERNKE | SPVFAPVYFP | EELHRKAALE | QDLAFWYGPR | WQEVIPYTPA | MQRYVKRLHE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VGRTEPELLV | AHAYTRYLGD | LSGGQVLKKI | AQKALDLPSS | GEGLAFFTFP | NIASATKFKQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYRSRMNSLE | MTPAVRQRVI | EEAKTAFLLN | IQLFEELQEL | LTHDTKDQSP | SRAPGLRQRA |
| 250 | 260 | 270 | 280 | ||
| SNKVQDSAPV | ETPRGKPPLN | TRSQAPLLRW | VLTLSFLVAT | VAVGLYAM |