P09560

PR
Gene name
raf1 (raf)
Protein name
RAF proto-oncogene serine/threonine-protein kinase
Names
C-RAF
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

164-360 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

476-501 (Activation loop from InterPro)

Target domain

340-600 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P09560

Entry ID Method Resolution Chain Position Source
AF-P09560-F1 Predicted AlphaFoldDB

No variants for P09560

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P09560

No associated diseases with P09560

6 regional properties for P09560

Type Name Position InterPro Accession
domain Protein kinase domain 340 - 600 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 342 - 596 IPR001245
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 137 - 185 IPR002219
domain Raf-like Ras-binding 56 - 130 IPR003116
active_site Serine/threonine-protein kinase, active site 455 - 467 IPR008271
binding_site Protein kinase, ATP binding site 346 - 366 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEHIQGAWKT LSNGFGFKES VFEGSSCMSP TIVHQFGYQR RASDDGKLSD TSKTSSTMRV
70 80 90 100 110 120
YLPNKQRTVV NVRSGMSLHD CLMKSLKVRG LQPECCAVFR LIQDPKGKLR LDWNTDAMSL
130 140 150 160 170 180
VGAELQVDFL DHVPLTTHNF VRKTFLKLAF CDICQKFLLN AFRCQTCGYK FHEHCSTKVP
190 200 210 220 230 240
TMCVDWSNIR QLLLFPNPNN IEGGSHTLPS LTMRRIGESV RIPVSSQQRY STPHPFSFST
250 260 270 280 290 300
PSPVSECSLS QRQRSTSTPN VHMVSTTMAV DSRVIEDALR SHSESGSPNN LSPTGWSNAK
310 320 330 340 350 360
APAPTHREKA ASSTGQEKNK IRARGQRDSS YYWEIIASEV MLSSRIGSGS FGTVYKGKWH
370 380 390 400 410 420
GDVAVKILKV TDPTPEQLQA FRNEVAVLRK TRHVNILLFM GYMTKDNLAI VTQWCEGSSL
430 440 450 460 470 480
YYHLHVLDTK FQMFQLIDIA RQTAQGMDYL HAKNIIHRDM KSNNIFLHEG LTVKIGDFGL
490 500 510 520 530 540
ATVKTRWSGS QQVEQLTGSI LWMAPEVIRM QDNNPFSFQS DVYSYGIVLY ELMTGELPYS
550 560 570 580 590 600
HIRDRDQIIF LVGRGGVVPD LSKLYKNCPK AMKRLVADSI KKLRDERPLF PQILSSIELL
610 620 630
QHSLPKINRS ALEPSLHRAA HTEDISSCAL TSTRLPVF