P09250
Gene name |
TK |
Protein name |
Thymidine kinase |
Names |
|
Species |
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
KEGG Pathway |
|
EC number |
2.7.1.21: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for P09250
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
4 variants for P09250
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 130 | R>Q | strain: Isolate 7-1-3 [UniProt] | No | ||
| 154 | L>P | strain: Isolate 40a2 [UniProt] | No | ||
| 288 | S>L | strain: Ellen, ppIIa, Isolate clinical GK, Isolate 7-1-3, Isolate 101 and Isolate 3-5-2/KB3 [UniProt] | No | ||
| 319 | A>V | strain: Isolate clinical GK [UniProt] | No |
No associated diseases with P09250
No regional properties for P09250
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P09250 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.21 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| thymidine kinase activity | Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA biosynthetic process | The biosynthetic process resulting in the formation of DNA. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| TMP biosynthetic process | The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTDKTDVKM | GVLRIYLDGA | YGIGKTTAAE | EFLHHFAITP | NRILLIGEPL | SYWRNLAGED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AICGIYGTQT | RRLNGDVSPE | DAQRLTAHFQ | SLFCSPHAIM | HAKISALMDT | STSDLVQVNK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EPYKIMLSDR | HPIASTICFP | LSRYLVGDMS | PAALPGLLFT | LPAEPPGTNL | VVCTVSLPSH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSRVSKRARP | GETVNLPFVM | VLRNVYIMLI | NTIIFLKTNN | WHAGWNTLSF | CNDVFKQKLQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSECIKLREV | PGIEDTLFAV | LKLPELCGEF | GNILPLWAWG | METLSNCSRS | MSPFVLSLEQ |
| 310 | 320 | 330 | 340 | ||
| TPQHAAQELK | TLLPQMTPAN | MSSGAWNILK | ELVNAVQDNT | S |