AiPD: Autoinhibited Protein Database

P08833

Gene name	IGFBP1 (IBP1)
Protein name	Insulin-like growth factor-binding protein 1
Names	IBP-1, IGF-binding protein 1, IGFBP-1, Placental protein 12, PP12
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3484
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-171 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

78-171 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for P08833

Entry ID	Method	Resolution	Chain	Position	Source
1ZT3	X-ray	180 A	A	172-251	PDB
1ZT5	X-ray	182 A	A	172-251	PDB
2DSQ	X-ray	280 A	G/H	166-259	PDB
AF-P08833-F1	Predicted				AlphaFoldDB

257 variants for P08833

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA4249529 rs747541587	5	P>S		No	ClinGen ExAC gnomAD
rs148297000 CA4249530	6	V>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs777344533 CA4249531	8	R>G		No	ClinGen ExAC gnomAD
rs1327235387 CA367438948	8	R>H		No	ClinGen TOPMed gnomAD
CA4249532 rs111255251	9	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770884467 CA4249533	10	W>*		No	ClinGen ExAC gnomAD
CA367438991 rs1156892103	12	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA158012801 rs1013993759	16	L>P		No	ClinGen Ensembl
CA4249537 rs775494697	18	V>L		No	ClinGen ExAC TOPMed gnomAD
CA158012807 rs1033685071	19	Q>*		No	ClinGen TOPMed
CA4249539 rs138841724	20	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA367439164 rs1334797638	21	G>R		No	ClinGen gnomAD
rs1334797638 CA367439161	21	G>S		No	ClinGen gnomAD
CA4249540 rs776759256	22	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1310779795 CA367439178	22	V>M		No	ClinGen TOPMed gnomAD
rs761982277 CA4249541	24	A>V		No	ClinGen ExAC gnomAD
rs765612314 CA4249542	27	P>A		No	ClinGen ExAC gnomAD
rs758909946 CA4249544	27	P>R		No	ClinGen ExAC gnomAD
rs765612314 CA4249543	27	P>T		No	ClinGen ExAC gnomAD
CA4249545 rs766860058	28	W>C		No	ClinGen ExAC gnomAD
CA158012859 rs373659181	29	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA367439318 rs1437433476	30	C>Y		No	ClinGen gnomAD
CA367439340 rs1562794853	31	A>E		No	ClinGen Ensembl
rs777300659 CA4249548	31	A>P		No	ClinGen ExAC TOPMed gnomAD
rs748974940 CA4249549	33	C>*		No	ClinGen ExAC gnomAD
rs1375805567 CA367439400	35	A>S		No	ClinGen gnomAD
CA4249552 rs745725926	37	K>R		No	ClinGen ExAC gnomAD
CA4249553 rs376937815	39	A>E		No	ClinGen ESP ExAC gnomAD
CA158012892 rs570379585	39	A>T		No	ClinGen 1000Genomes
CA158012906 rs376937815	39	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs775339662 CA4249554	40	L>F		No	ClinGen ExAC TOPMed gnomAD
CA4249555 rs746935293	41	C>Y		No	ClinGen ExAC gnomAD
rs1583659797 CA367439538	42	P>L		No	ClinGen Ensembl
TCGA novel	42	P>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1439444908 CA367439532	42	P>S		No	ClinGen gnomAD
rs762033595 CA4249559	44	V>L		No	ClinGen ExAC TOPMed gnomAD
CA367439602 rs1346405253	45	S>Y		No	ClinGen TOPMed
CA4249560 rs769935884	46	A>T		No	ClinGen ExAC gnomAD
CA4249561 rs773415946	47	S>*		No	ClinGen ExAC TOPMed gnomAD
CA4249562 rs537400616	48	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1265229030 CA367439650	49	S>L		No	ClinGen gnomAD
rs1193074747 CA367439645	49	S>T		No	ClinGen gnomAD
CA367439681 rs1176635610	51	V>A		No	ClinGen gnomAD
rs1434812225 CA367439677	51	V>F		No	ClinGen gnomAD
CA367439690 rs1583659842	52	T>N		No	ClinGen Ensembl
rs766739368 CA367439706	53	R>G		No	ClinGen ExAC gnomAD
CA367439716 rs1463803822	53	R>P		No	ClinGen TOPMed gnomAD
CA367439714 rs1463803822	53	R>Q		No	ClinGen TOPMed gnomAD
rs752043707 CA4249564	55	A>S		No	ClinGen ExAC gnomAD
CA367439737 rs752043707	55	A>T		No	ClinGen ExAC gnomAD
CA158012969 rs1032901864	56	G>A		No	ClinGen Ensembl
CA4249566 rs370226543	56	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs753334604 CA4249567	58	G>S		No	ClinGen ExAC gnomAD
rs1302538902 CA367439808	58	G>V		No	ClinGen TOPMed gnomAD
rs1217126161 CA367439862	61	P>S		No	ClinGen gnomAD
rs1318871592 CA367439902	63	C>G		No	ClinGen gnomAD
TCGA novel	63	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA158012986 rs910893952	64	A>D		No	ClinGen TOPMed
CA367439919 rs1213194448	64	A>P		No	ClinGen gnomAD
rs1213194448 CA367439921	64	A>S		No	ClinGen gnomAD
CA367439964 rs1489480063	66	P>L		No	ClinGen TOPMed gnomAD
rs1489480063 CA367439961	66	P>R		No	ClinGen TOPMed gnomAD
TCGA novel	66	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367439983 rs1476751607	68	G>R		No	ClinGen TOPMed gnomAD
CA367439980 rs1476751607	68	G>S		No	ClinGen TOPMed gnomAD
rs1195568130 CA367439997	69	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA367440050 rs1162202771	71	C>*		No	ClinGen gnomAD
rs1583659914 CA367440047	71	C>F		No	ClinGen Ensembl
CA367440055 rs1351148829	72	G>S		No	ClinGen gnomAD
CA367440092 rs1294648621	73	V>G		No	ClinGen gnomAD
rs779860070 CA4249572	73	V>L		No	ClinGen ExAC gnomAD
CA4249573 rs746942337	74	A>P		No	ClinGen ExAC gnomAD
CA367440133 rs1341463387	76	A>S		No	ClinGen gnomAD
CA367440141 rs1562794950	76	A>V		No	ClinGen Ensembl
CA158013002 rs972770798	77	R>C		No	ClinGen TOPMed
CA367440177 rs1317620826	78	C>*		No	ClinGen TOPMed
CA367440193 rs1232927605	79	A>V		No	ClinGen gnomAD
rs1259177665 CA367440200	80	R>W		No	ClinGen TOPMed
rs781252053 CA367440221	81	G>A		No	ClinGen ExAC TOPMed gnomAD
rs781252053 CA367440219	81	G>E		No	ClinGen ExAC TOPMed gnomAD
rs781252053 CA4249575	81	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1448789856 CA367440247	83	S>N		No	ClinGen TOPMed
CA4249576 rs748293019	83	S>R		No	ClinGen ExAC TOPMed gnomAD
rs1448789856 CA367440248	83	S>T		No	ClinGen TOPMed
rs1487249479 CA367440269	84	C>F		No	ClinGen gnomAD
rs1218583203 CA367440282	85	R>S		No	ClinGen gnomAD
CA367440313 rs1179762272	86	A>E		No	ClinGen gnomAD
CA367440300 rs1474735357	86	A>T		No	ClinGen gnomAD
TCGA novel	87	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4249579 rs773469271	88	P>L		No	ClinGen ExAC TOPMed
CA367440349 rs1157730907	89	G>R		No	ClinGen gnomAD
rs771227052 CA4249581	90	E>*		No	ClinGen ExAC TOPMed gnomAD
rs747136225	90	E>S	Variant assessed as Somatic; 0.0001703 impact. [NCI-TCGA]	No	NCI-TCGA
rs1473458407 CA367440419	92	Q>H		No	ClinGen TOPMed
CA367440429 rs1235848036	93	P>S		No	ClinGen TOPMed
rs1457764208 CA367440479	95	H>Q		No	ClinGen TOPMed
rs1057021005 CA158013019	95	H>R		No	ClinGen TOPMed gnomAD
CA367440508 rs1239140332	97	L>F		No	ClinGen TOPMed
rs1207125876 CA367440512	97	L>H		No	ClinGen TOPMed
CA367440533 rs1301372580	99	R>G		No	ClinGen gnomAD
CA367440540 rs1320317177	99	R>L		No	ClinGen TOPMed
rs1229002119 CA367440571	102	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4249583 rs759968281	103	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4249584 rs768208775	103	A>V		No	ClinGen ExAC gnomAD
CA158013045 rs949506485	104	C>*		No	ClinGen Ensembl
CA158013039 rs896568415	104	C>R		No	ClinGen Ensembl
rs1286568446 CA367440612	105	V>E		No	ClinGen gnomAD
CA367440605 rs1361607428	105	V>L		No	ClinGen TOPMed
CA367440626 rs1485231887	106	Q>*		No	ClinGen gnomAD
CA4249587 rs764809981	106	Q>H		No	ClinGen ExAC gnomAD
rs10156070 CA4249586	106	Q>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	106	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367440656 rs1483356970	107	E>G		No	ClinGen gnomAD
CA158013090 rs374816684	108	S>F		No	ClinGen 1000Genomes TOPMed gnomAD
rs1001299186 CA367440682	109	D>A		No	ClinGen TOPMed gnomAD
CA158013092 rs1001299186	109	D>G		No	ClinGen TOPMed gnomAD
rs937250620 CA158013091	109	D>N		No	ClinGen TOPMed gnomAD
rs1160985621 CA367440702	110	A>P		No	ClinGen gnomAD
CA367440704 rs1160985621	110	A>S		No	ClinGen gnomAD
rs1331885776 CA367440727	111	S>F		No	ClinGen gnomAD
CA158013096 rs76681789	112	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA367440745 rs1414324414	113	P>L		No	ClinGen TOPMed gnomAD
CA367440742 rs1414324414	113	P>R		No	ClinGen TOPMed gnomAD
rs78816847 CA4249588	113	P>S		No	ClinGen ExAC gnomAD
rs41258845 VAR_049564 CA4249589	114	H>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1361167833 CA367440751	114	H>L		No	ClinGen gnomAD
CA367440753 rs1361167833	114	H>P		No	ClinGen gnomAD
rs1390110643 CA367441440	117	E>D		No	ClinGen gnomAD
CA4249616 rs749453265	118	A>E		No	ClinGen ExAC TOPMed gnomAD
CA367441441 rs777838279	118	A>S		No	ClinGen ExAC TOPMed gnomAD
rs777838279 CA4249615	118	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1029772778 CA158013949	120	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1029772778 CA158013947	120	S>T		No	ClinGen Ensembl
CA4249618 rs531101667	121	P>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA367441476 rs1399209964	121	P>S		No	ClinGen gnomAD
rs1342089911 CA367441495	122	E>D		No	ClinGen gnomAD
rs1016874043 CA158013962	125	E>K		No	ClinGen TOPMed gnomAD
CA367441538 rs1283172493	126	S>N		No	ClinGen gnomAD
CA4249619 COSM1243316 rs775473368	127	T>M	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA367441560 rs1437526404	128	E>A		No	ClinGen TOPMed
TCGA novel	128	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775949573 CA4249621	129	I>V		No	ClinGen ExAC gnomAD
CA158013979 rs910135238	130	T>P		No	ClinGen gnomAD
rs941595873 CA158013985	131	E>*		No	ClinGen TOPMed
rs1216411756 CA367441604	132	E>K		No	ClinGen gnomAD
CA4249622 rs747531500	133	E>D		No	ClinGen ExAC gnomAD
rs776999181 CA4249624	135	L>Q		No	ClinGen ExAC gnomAD
rs765781399 CA4249626	137	N>S		No	ClinGen ExAC gnomAD
CA158014002 rs539115833	139	H>L		No	ClinGen Ensembl
rs759147038 CA4249628	141	M>T		No	ClinGen ExAC gnomAD
rs1409401742 CA367441747	143	P>S		No	ClinGen gnomAD
CA367441764 rs1308828636	144	S>F		No	ClinGen gnomAD
CA4249629 rs767318856	144	S>T		No	ClinGen ExAC gnomAD
rs755900621 CA4249631	145	E>*		No	ClinGen ExAC gnomAD
rs138105891 CA4249632	148	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA158014029 rs949807893	148	H>Y		No	ClinGen Ensembl
rs753700859 CA4249633	149	S>Y		No	ClinGen ExAC gnomAD
CA158014043 rs868069218	151	L>I		No	ClinGen Ensembl
CA158014065 rs17854947	151	L>P		No	ClinGen Ensembl
CA4249635 rs9658209	153	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4249636 rs566229997	154	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs758636859 CA4249637	154	A>V		No	ClinGen ExAC gnomAD
TCGA novel	156	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367441911 rs1284427013	156	S>N		No	ClinGen gnomAD
rs1356358036 CA367441930	157	T>I		No	ClinGen TOPMed gnomAD
CA4249638 COSM1210366 rs552821872	158	Y>C	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs1255783346 CA367441972	160	G>V		No	ClinGen gnomAD
CA4249639 rs368245176	161	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4249641 rs781746463	162	K>E		No	ClinGen ExAC gnomAD
rs752223172 CA367442008	163	A>G		No	ClinGen ExAC TOPMed gnomAD
rs752223172 CA4249642	163	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1205490817 CA367442036	166	V>I		No	ClinGen gnomAD
TCGA novel	168	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs546971229 CA4249643	169	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4249644 rs773682817	170	K>R		No	ClinGen ExAC gnomAD
TCGA novel	171	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4249663 rs778342842 CA4249664	174	E>D		No	ClinGen ExAC TOPMed gnomAD
CA367442207 rs1463639023	174	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs760281769 CA4249666	175	P>H		No	ClinGen ExAC TOPMed gnomAD
CA4249667 rs760281769	175	P>L		No	ClinGen ExAC TOPMed gnomAD
rs768523904 CA4249665	175	P>T		No	ClinGen ExAC gnomAD
rs1473391802 CA367442237	176	C>*		No	ClinGen TOPMed
CA4249668 rs776233561	177	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs369196046 CA4249669 COSM281874	177	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs948759128 CA158014688	178	I>T		No	ClinGen gnomAD
CA4249672 rs763174847	182	R>G		No	ClinGen ExAC gnomAD
rs1065782 VAR_011905 CA4249673	183	V>I		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs146202574 COSM3765352 CA4249675	184	V>I	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs146202574 CA367442317	184	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367442322 rs1430137720	185	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1199838569 CA367442341	186	S>N		No	ClinGen gnomAD
rs1434754969 CA367442336	186	S>R		No	ClinGen gnomAD
CA367442355 rs1331427952	187	L>S		No	ClinGen TOPMed
CA158014703 rs759646065	188	A>T		No	ClinGen Ensembl
rs767935469 CA4249676	191	Q>P		No	ClinGen ExAC gnomAD
rs1476647274 CA367442422	193	T>A		No	ClinGen TOPMed gnomAD
rs974487740 CA158014706	193	T>I		No	ClinGen TOPMed
CA367442421 rs1476647274	193	T>S		No	ClinGen TOPMed gnomAD
rs756491869 CA4249678	194	S>P		No	ClinGen ExAC gnomAD
CA367442445 rs1389200541	195	G>R		No	ClinGen gnomAD
CA158014714 rs752931809	196	E>D		No	ClinGen TOPMed gnomAD
TCGA novel	197	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA158014716 rs763075160	197	E>D		No	ClinGen Ensembl
TCGA novel	197	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA158014718 rs1053533634	199	S>A		No	ClinGen Ensembl
TCGA novel	199	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	200	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367442534 rs1284303624	202	Y>S		No	ClinGen gnomAD
rs1445915852 CA367442545	203	L>P		No	ClinGen gnomAD
CA4249681 rs757935661	203	L>V		No	ClinGen ExAC gnomAD
rs1321034000 CA367442558	204	P>L		No	ClinGen TOPMed
CA4249682 rs369361373	204	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs369361373 CA4249683	204	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1011797601 CA158014728	206	C>S		No	ClinGen Ensembl
TCGA novel	208	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367442615 rs1244148125	209	N>D		No	ClinGen gnomAD
rs1458636725 CA367442631	210	G>*		No	ClinGen TOPMed
rs747950009 CA4249686	212	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4249687 rs769609357	214	S>N	Variant assessed as Somatic; 0.0003236 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1487147268 CA367442697	215	R>K		No	ClinGen gnomAD
TCGA novel	218	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs117054298 CA4249705	218	E>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773089001 CA4249706	220	S>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1386183199 CA367443128	221	M>T		No	ClinGen TOPMed
rs201339143 CA4249707	223	G>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	224	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367443175 rs1453446235	225	A>E		No	ClinGen TOPMed gnomAD
rs774337911 CA4249709	227	L>P		No	ClinGen ExAC gnomAD
CA158015103 rs905081489	229	W>*		No	ClinGen Ensembl
rs1242126188 CA367443225	229	W>L		No	ClinGen gnomAD
CA4249710 rs759586433	230	C>Y		No	ClinGen ExAC gnomAD
rs370766303 CA4249712	231	V>I	Variant assessed as Somatic; 4.627e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs760906614 CA4249714	237	K>R		No	ClinGen ExAC gnomAD
rs764456292 CA4249715	240	P>R		No	ClinGen ExAC gnomAD
rs956735181 CA158015128	241	G>E		No	ClinGen TOPMed
CA367443370 rs956735181	241	G>V		No	ClinGen TOPMed
rs1179398441 CA367443381	242	S>F		No	ClinGen gnomAD
rs1562574065 CA367443372	242	S>T		No	ClinGen Ensembl
CA4249717 rs762162861	243	P>A		No	ClinGen ExAC TOPMed gnomAD
rs762162861 CA367443384	243	P>S		No	ClinGen ExAC TOPMed gnomAD
CA4249718 rs141120529	244	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1562574071 CA367443413	246	R>G		No	ClinGen Ensembl
rs754485600 CA4249721	247	G>V		No	ClinGen ExAC TOPMed gnomAD
CA367443443 rs1583661895	248	D>A		No	ClinGen Ensembl
CA367443448 rs1470382164	248	D>E		No	ClinGen gnomAD
TCGA novel	249	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375166026 CA4249723	250	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs780713458 CA4249722	250	N>S		No	ClinGen ExAC TOPMed
TCGA novel	251	C>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA158015151 rs1020324299	251	C>Y		No	ClinGen Ensembl
CA367443499 COSM341493 rs1209674213	252	Q>H	lung [Cosmic]	No	ClinGen cosmic curated TOPMed
CA4249724 VAR_003821 rs4619	253	I>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA367443509 rs1331292020	253	I>T		No	ClinGen TOPMed
rs531622833 CA367443551	256	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1331567482 CA367443560	257	V>A		No	ClinGen TOPMed
rs770829397 CA4249727	258	Q>*		No	ClinGen ExAC gnomAD
rs778759405 CA4249728	260	N>R		No	ClinGen ExAC gnomAD

No associated diseases with P08833

3 regional properties for P08833

Type	Name	Position	InterPro Accession
domain	Thyroglobulin type-1	173 - 255	IPR000716
domain	Insulin-like growth factor-binding protein, IGFBP	22 - 107	IPR000867
conserved_site	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site	56 - 71	IPR017891

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

4 GO annotations of molecular function

Name	Definition
insulin-like growth factor binding	Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it.
insulin-like growth factor I binding	Binding to insulin-like growth factor I.
insulin-like growth factor II binding	Binding to insulin-like growth factor II.
signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

8 GO annotations of biological process

Name	Definition
insulin receptor signaling pathway	The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
multicellular organism aging	An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).
negative regulation of canonical Wnt signaling pathway	Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of cell growth	Any process that activates or increases the frequency, rate, extent or direction of cell growth.
regulation of insulin-like growth factor receptor signaling pathway	Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.
response to organic cyclic compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
tissue regeneration	The regrowth of lost or destroyed tissues.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSEVPVARVW	LVLLLLTVQV	GVTAGAPWQC	APCSAEKLAL	CPPVSASCSE	VTRSAGCGCC
70	80	90	100	110	120
PMCALPLGAA	CGVATARCAR	GLSCRALPGE	QQPLHALTRG	QGACVQESDA	SAPHAAEAGS
130	140	150	160	170	180
PESPESTEIT	EEELLDNFHL	MAPSEEDHSI	LWDAISTYDG	SKALHVTNIK	KWKEPCRIEL
190	200	210	220	230	240
YRVVESLAKA	QETSGEEISK	FYLPNCNKNG	FYHSRQCETS	MDGEAGLCWC	VYPWNGKRIP
250
GSPEIRGDPN	CQIYFNVQN