P08662
Gene name |
merA |
Protein name |
Mercuric reductase |
Names |
Hg(II) reductase |
Species |
Serratia marcescens |
KEGG Pathway |
|
EC number |
1.16.1.1: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P08662
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P08662-F1 | Predicted | AlphaFoldDB |
No variants for P08662
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P08662 | |||||
No associated diseases with P08662
5 regional properties for P08662
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | 343 - 444 | IPR004099 |
| domain | Heavy metal-associated domain, HMA | 1 - 65 | IPR006121 |
| active_site | Pyridine nucleotide-disulphide oxidoreductase, class I, active site | 133 - 143 | IPR012999 |
| conserved_site | Heavy-metal-associated, conserved site | 6 - 35 | IPR017969 |
| domain | FAD/NAD(P)-binding domain | 100 - 341 | IPR023753 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.16.1.1 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| mercury (II) reductase activity | Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH. |
| metal ion binding | Binding to a metal ion. |
| oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor | Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell redox homeostasis | Any process that maintains the redox environment of a cell or compartment within a cell. |
| response to mercury ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTHLKITGMT | CDSCAAHVKE | ALEKVPGVQS | AIVSYAKGAA | QLALDPGTAP | DALTAAVAGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GYKAMLADAP | PTDNRTGLFD | KVRGWMGAAD | KGSGAERPLQ | VAVIGSGGAA | MAAALKAVEQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GAQVTLIERG | TIGGTCVNVG | CVPSKIMIRA | AHIAHLRRES | PFDGGMPPTP | PTILRERLLA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QQQARVEELR | HAKYEGILDG | NSAITVRHGE | ARFKDDRDLS | VSLNEGGERV | VMFDRCLVAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GASPAMPPIP | GLKESPYWTS | TEALVSDTIP | ERLAVIGSSV | VALELAQAFA | RLGSQVTILA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RNTLFFRDDP | SIGEAVTAAF | RAEGIKVLEH | TQASQVAHVN | GEDPQVATVG | YSEAEAHHDG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IETDSRTLTL | DNVPRALANF | DTRGFIKLVI | EEGSGRLIGV | QVVAPEAGEL | IQTAVLAIRN |
| 430 | 440 | 450 | |||
| RMTVQELADQ | LFPYLTMVEG | LKLAAQTFTK | DVKQLSCCAG |